DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14921 and DNAAF4

DIOPT Version :9

Sequence 1:	NP_609491.1	Gene:	CG14921 / 34547	FlyBaseID:	FBgn0032345	Length:	240	Species:	Drosophila melanogaster
Sequence 2:	NP_570722.2	Gene:	DNAAF4 / 161582	HGNCID:	21493	Length:	420	Species:	Homo sapiens

Alignment Length:	273	Identity:	76/273 - (27%)
Similarity:	116/273 - (42%)	Gaps:	66/273 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VQIS-----QTEEDIKISIELNRLVTRKPDVVLLPQYLKFNNPPIFFERHLAQEIDEMASFCRIF 61
            :|:|     ||:..:.:|:.|..:..|..||.....|||.|.||..||..|...||:.:|..:|.
Human     3 LQVSDYSWQQTKTAVFLSLPLKGVCVRDTDVFCTENYLKVNFPPFLFEAFLYAPIDDESSKAKIG 67

  Fly    62 KNEARIVLVKKEKGLW---------PEMFQKLDKEALMQ---------------KR------LEI 96
            .:.....|.|||..:|         .||.|::.:::::|               ||      |.:
Human    68 NDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSV 132

  Fly    97 ADLIVERNKKRDE-----------KALERY-DNKRRAEIQKEIQRETDMRERVKQFQENSVREAL 149
            ...|.|..:|:.|           ||||.: :.:|:||.||:||||..:.::.||.:|.
Human   133 MMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEE------ 191

  Fly   150 VVDVRKEAK---ATPKPDTLQYPPSSGGASRLAT-PLMRPPMSSVRGSGRINVNFTTQHKRVTPK 210
                ||:.|   .|....:....|....:..:.| .|....:.:.|..|.|.:|||   .||.|.
Human   192 ----RKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFT---PRVFPT 249

  Fly   211 --RESQAAMEKAY 221
              ||||.|.|:.:
Human   250 ALRESQVAEEEEW 262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14921	NP_609491.1	p23_DYX1C1_like	4..81	CDD:107226	27/90 (30%)
DNAAF4	NP_570722.2	Mediates interaction with ESR1 and STUB1. /evidence=ECO:0000269\|PubMed:19423554	7..103		28/95 (29%)
		p23_DYX1C1_like	10..87	CDD:107226	25/76 (33%)
		TPR_11	289..353	CDD:290150
		TPR 1	290..323
		TPR repeat	290..318	CDD:276809
		TPR repeat	323..353	CDD:276809
		TPR 2	324..357
		TPR repeat	364..394	CDD:276809
		TPR 3	366..399
		TPR_1	367..399	CDD:278916
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	69	1.000	Inparanoid score	I5337
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105298
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.720