DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14921 and Bbs4

DIOPT Version :9

Sequence 1:	NP_609491.1	Gene:	CG14921 / 34547	FlyBaseID:	FBgn0032345	Length:	240	Species:	Drosophila melanogaster
Sequence 2:	NP_780534.1	Gene:	Bbs4 / 102774	MGIID:	2143311	Length:	520	Species:	Mus musculus

Alignment Length:	179	Identity:	41/179 - (22%)
Similarity:	75/179 - (41%)	Gaps:	49/179 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 KLDK-EALMQKRLEIADLIVERNKKRDEKALERY-DNKRRAEIQKE---IQRETDMRERVKQF-Q 141
            :||| ..|:  .|..|.|:..:.:|:  .||.:| :.:::....|:   ::.:::|.|..::. .
Mouse   366 RLDKCNPLV--NLNYAVLLYNQGEKK--SALAQYQEMEKKVNFLKDNSPLEFDSEMVEMAQKLGA 426

  Fly   142 ENSVREALVVDVRKEAKATPKPDTLQYPPSSGGASRLATPLMRPPMSSVRGSGRINVNFTTQHKR 206
            ...|.||||     ..|....|.| ::..:||  |:.||  ::.|:.|::..|:
Mouse   427 ALQVGEALV-----WTKPVKDPKT-KHRTNSG--SKSAT--LQQPLGSIQALGQ----------- 470

  Fly   207 VTPKRESQAAMEKAYAAAGG--------------PNANVQ-SPMESVDE 240
               ...|.||..|..:.|.|              |...|: ||.|:.::
Mouse   471 ---AMSSAAAYRKILSGAVGAQLPKPPSLPLEPEPEPTVEASPTEASEQ 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14921	NP_609491.1	p23_DYX1C1_like	4..81	CDD:107226
Bbs4	NP_780534.1	Required for localization to centrosomes. /evidence=ECO:0000250	1..66
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		TPR 1	67..100
		TPR repeat	68..95	CDD:276809
		Interaction with PCM1. /evidence=ECO:0000250	101..337
		TPR_11	101..166	CDD:290150
		TPR repeat	101..129	CDD:276809
		TPR repeat	134..164	CDD:276809
		TPR_11	136..199	CDD:290150
		TPR_11	169..233	CDD:290150
		TPR repeat	169..196	CDD:276809
		TPR	170..201	CDD:197478
		TPR repeat	202..229	CDD:276809
		TPR repeat	236..264	CDD:276809
		TPR_11	237..301	CDD:290150
		TPR repeat	270..298	CDD:276809
		TPR_11	272..335	CDD:290150
		TPR repeat	303..333	CDD:276809
		TPR_11	305..369	CDD:290150	1/2 (50%)
		Required for localization to centrosomes. /evidence=ECO:0000250	338..520		41/179 (23%)
		TPR repeat	338..366	CDD:276809	41/179 (23%)
		TPR_16	342..400	CDD:290168	11/37 (30%)
		TPR repeat	372..397	CDD:276809	8/28 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	488..520		5/29 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900