Protein Alignment CG6230 and SPF1

DIOPT Version :10

• Sequence 1: NP_609490.1
• Gene: CG6230 / 34546
• FlyBaseID: FBgn0027582
• Length: 1225
• Species: Drosophila melanogaster
• Sequence 2: NP_010883.3
• Gene: SPF1 / 856681
• SGDID: S000000757
• Length: 1215
• Species: Saccharomyces cerevisiae
• Alignment Length: 1227
• Identity: 489/1227 - (39%)
• Similarity: 708/1227 - (57%)
• Gaps: 129/1227 - (10%)

  Fly    58 VLPFVPLYLSAFYLWIN-----VTGGQENDTTNNDVITADNQTTTDNITTWNDVGFIGVLAIAFL 117
            ||||.|||.:...|:..     :.|.:                       |..| ::|.|  ..|
Yeast    29 VLPFFPLYATFAQLYFQQYDRYIKGPE-----------------------WTFV-YLGTL--VSL 67

  Fly   118 HILTLLFCYWSVHVLA---FLTCRRVKLPGANVLAKVVPTPNNGNSKIVPIRSSKLEDGSTQYYF 179
            :||.:|...|:|.:.|   :.|.:.|. ...::|  :..|||||:..||.|: ...|.||.|.:|
Yeast    68 NILVMLMPAWNVKIKAKFNYSTTKNVN-EATHIL--IYTTPNNGSDGIVEIQ-RVTEAGSLQTFF 128

  Fly   180 VFQKTKYVWNEDRKTFRAVEFPV--NGLLSTYSSSRGLETEEDIKRATQTYGNNEMEMVVPEFHE 242
            .|||.:::|:|:.:.|.:.:|.|  :..:..:...:|  ...|:....:.||.|..::.:|.|.|
Yeast   129 QFQKKRFLWHENEQVFSSPKFLVDESPKIGDFQKCKG--HSGDLTHLKRLYGENSFDIPIPTFME 191

  Fly   243 LFIERATAPFFVFQVFSVGLWCMDDYWYYSLFTLFMLIAFECTIVKQQLRNMSEIRKMGNKPYLI 307
            ||.|.|.||.||||||.|.||.:|::||||||.|||:|:.|...|.|:|..:.|.|.||.|||.|
Yeast   192 LFKEHAVAPLFVFQVFCVALWLLDEFWYYSLFNLFMIISMEAAAVFQRLTALKEFRTMGIKPYTI 256

  Fly   308 YAFRQNKWRHLGSDELLPGDLVSITRSQNDNIVPCDLVILRGSCIVDESMLTGESVPLMKESLE- 371
            ..||..||..|.::||||.|||||||:..::.:||||::|.||.||:|:||:|||.||:|||::
Yeast   257 NVFRNKKWVALQTNELLPMDLVSITRTAEESAIPCDLILLDGSAIVNEAMLSGESTPLLKESIKL 321

  Fly   372 --SLDNLDVEMDAEGDGKLFVLFGGTKVVQHTAPTKES--LRAPDGGCIGYVIRTGFNTSQGKLL 432
              |.|||.:    :|..|:.||.||||.:|.|.|..:|  ...||||.:..|.:|||.||||.|:
Yeast   322 RPSEDNLQL----DGVDKIAVLHGGTKALQVTPPEHKSDIPPPPDGGALAIVTKTGFETSQGSLV 382

  Fly   433 RTILFGANRATENNVETFAFIAFLMVFAVAAASYVWVKGSEDPERNRYKLFLECTLILTSIIPPD 497
            |.:::.|.|.:.:|.|...||.||::|||.|:.||||:|:: ..|.:.||.|:|.||:||::||:
Yeast   383 RVMIYSAERVSVDNKEALMFILFLLIFAVIASWYVWVEGTK-MGRIQSKLILDCILIITSVVPPE 446

  Fly   498 LPIELTLAVNTSLIQLTKLFVFCTEPFRIPFAGKVQICCFDKTGTLTTDNLMVEGIAGLAPNGAC 562
            ||:|||:|||:||..|.|.:|:|||||||||||::.:||||||||||.::|:.||:||::.:...
Yeast   447 LPMELTMAVNSSLAALAKFYVYCTEPFRIPFAGRIDVCCFDKTGTLTGEDLVFEGLAGISADSEN 511

  Fly   563 V----PIEKAEGNTVQVLACCHSLALLDDG-LVGDPLEKATLAAVDWTLTKMDSVIPKRPQFKPL 622
            :    ...:|..:|:.|:...|:|..|:|| :||||:|||||.||.|.:.:.:|  ..|.....|
Yeast   512 IRHLYSAAEAPESTILVIGAAHALVKLEDGDIVGDPMEKATLKAVGWAVERKNS--NYREGTGKL 574

  Fly   623 KIIQRYHFSSALKRMSVLAGHLIPYSNEVKHIGAVKGAPEVIQKMLREVPADYEKVYLEYARRGA 687
            .||:|:.|||||||.:.:|.|     |:.. ..|||||||.|::.|.::|.:|:::|..:.|.|:
Yeast   575 DIIRRFQFSSALKRSASIASH-----NDAL-FAAVKGAPETIRERLSDIPKNYDEIYKSFTRSGS 633

  Fly   688 RVLALGIKDLGTLGAQRVREMKREEVECDLTFAGFLIISCPMKPDSKSVIKELIQSSHKVVMITG 752
            |||||..|.|..:...::.::.|::||.:|||.||||..||:|.|:...||.|.:|||:.:||||
Yeast   634 RVLALASKSLPKMSQSKIDDLNRDDVESELTFNGFLIFHCPLKDDAIETIKMLNESSHRSIMITG 698

  Fly   753 DSPLTACHVARELRFTRKKLIILTPPEEDRKNNWSWVSIDGDQSYELDTKPGSKKLSHLLATHDL 817
            |:||||.|||:|:.....:.:||....:...|...:..::...|...|....:...|.|...:|:
Yeast   699 DNPLTAVHVAKEVGIVFGETLILDRAGKSDDNQLLFRDVEETVSIPFDPSKDTFDHSKLFDRYDI 763

  Fly   818 CITGEGLQYLQQNQPQYMRQLLPQITVCARFAPKQKELVITQLKQLGYCTLMCGDGTNDVGALKH 882
            .:||..|..|:.:  ..:|.||....|.||.:|.|||.::..||.:||.|||||||||||||||.
Yeast   764 AVTGYALNALEGH--SQLRDLLRHTWVYARVSPSQKEFLLNTLKDMGYQTLMCGDGTNDVGALKQ 826

  Fly   883 ANVGVSLLTSAPVKRKRTEEEQQQAAANAAAI-AAQAQANANQ---------------------- 924
            |:||::||.......|:..|:::........| ..:..|..||
Yeast   827 AHVGIALLNGTEEGLKKLGEQRRLEGMKMMYIKQTEFMARWNQPQPPVPEPIAHLFPPGPKNPHY 891

  Fly   925 --------QLTTRERALRRRQEHLNQTQAR------------------LQNALRDM--EEQTMVK 961
                    .:.|.|  :|:..|..|.....                  |.|:..|.  :|...:|
Yeast   892 LKALESKGTVITPE--IRKAVEEANSKPVEVIKPNGLSEKKPADLASLLLNSAGDAQGDEAPALK 954

  Fly   962 LGDASIAAPFTSKSSSIMCVNHIIKQGRCTLVTTLQMFKILALNALIQAYCQSVLYIDGIKFSDT 1026
            |||||.|||||||.:::..|.:||:||||.||.|:||:||||||.||.||..|::|:.|:||.|.
Yeast   955 LGDASCAAPFTSKLANVSAVTNIIRQGRCALVNTIQMYKILALNCLISAYSLSIIYMAGVKFGDG 1019

  Fly  1027 QATMQGIFIAACFLFITRAKPLKTLSKVAPLPNIFNFYTISTILSQFAVHFGTLYYLTSQANILA 1091
            |||:.|:.::.|||.|:|.|||:.|||..|...|||.|.:.:||||||||..||.|:|::...|
Yeast  1020 QATVSGLLLSVCFLSISRGKPLEKLSKQRPQSGIFNVYIMGSILSQFAVHIATLVYITTEIYKL- 1083

  Fly  1092 PPREGKVKLYIDMDAEEKTKYDPNIVSSTVYIICLSLQVATIAVNYKGYPFMESLRSNRMLMYAI 1156
            .|||.:|.|       || ::.|:::::.::||.|..||:|.||||:|.||.|::|||:.:.|.:
Yeast  1084 EPREPQVDL-------EK-EFAPSLLNTGIFIIQLVQQVSTFAVNYQGEPFRENIRSNKGMYYGL 1140

  Fly  1157 GASAALVILLSTGLAPELTEFFEIIDFPTDFRKTLLGVLVLDIVGAFLLDRICSFLF 1213
            .....|.:..:|...|||.|..:.:....||:..|...|:||..|::.::....|.|
Yeast  1141 LGVTGLALASATEFLPELNEAMKFVPMTDDFKIKLTLTLLLDFFGSWGVEHFFKFFF 1197

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6230	NP_609490.1	P-type_ATPase_cation	220..1152	CDD:319843	428/992 (43%)
SPF1	NP_010883.3	P-type_ATPase_cation	169..1136	CDD:319843	428/992 (43%)