DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6230 and PMA2

DIOPT Version :9

Sequence 1:	NP_609490.1	Gene:	CG6230 / 34546	FlyBaseID:	FBgn0027582	Length:	1225	Species:	Drosophila melanogaster
Sequence 2:	NP_015289.1	Gene:	PMA2 / 856071	SGDID:	S000005957	Length:	947	Species:	Saccharomyces cerevisiae

Alignment Length:	987	Identity:	210/987 - (21%)
Similarity:	349/987 - (35%)	Gaps:	290/987 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 LSTYSSSRGLETEEDIKRATQTYGNNEM----EMVVPEFHELFIERATAPF-FVFQVFSVGLWCM 265
            ||| ..:.|| |.:::.|..:.||.|:|    |.::.:|...|:    .|. ||.:..::....:
Yeast   109 LST-DPAYGL-TSDEVARRRKKYGLNQMAEENESLIVKFLMFFV----GPIQFVMEAAAILAAGL 167

  Fly   266 DDYWYYSLFTLFMLI--------AFECTIVKQQLRNMSEIRKMGNKPYLIYAFRQNKWRHLGSDE 322
            .|:....:....:|:        .|:...:..:|:     :.:.|...:|   |..:...:.::|
Yeast   168 SDWVDVGVICALLLLNASVGFIQEFQAGSIVDELK-----KTLANTATVI---RDGQLIEIPANE 224

  Fly   323 LLPGDLVSITRSQNDNIVPCDLVILRGSCI--VDESMLTGESVPLMKESLESLDNLDVEMDAEGD 385
            ::||:::.:   ::..|.|.|..|:...|.  :|:|.:||||:...|.
Yeast   225 VVPGEILQL---ESGTIAPADGRIVTEDCFLQIDQSAITGESLAAEKH----------------- 269

  Fly   386 GKLFVLFGGTKVVQHTAPTKESLRAPDGGCIGYVIRTGFNTSQGKLLRTILFGANRATENN-VET 449
                  :|.......|..|.|:...        |..||.||..|:  ...|.|.....|.: .|.
Yeast   270 ------YGDEVFSSSTVKTGEAFMV--------VTATGDNTFVGR--AAALVGQASGVEGHFTEV 318

  Fly   450 FAFIA-FLMVFAVAAASYVWVKGSEDPERNRYKL-----FLECTLILTSI-IPPDLPIELTLAVN 507
            ...|. .|:|..:|....||....       |:.     .|..||.:|.| :|..||..:|..:.
Yeast   319 LNGIGIILLVLVIATLLLVWTACF-------YRTVGIVSILRYTLGITIIGVPVGLPAVVTTTMA 376

  Fly   508 TSLIQLTKLFVFCTEPFRIPFAGKVQICCFDKTGTLTTDNLMVE---GIAGLAPNGACVPIEKAE 569
            .....|.|......:...|.....|:|.|.|||||||.:.|.:.   .:.|::|:..
Yeast   377 VGAAYLAKKQAIVQKLSAIESLAGVEILCSDKTGTLTKNKLSLHEPYTVEGVSPDDL-------- 433

  Fly   570 GNTVQVLACCHSLALLDDGLVGDPLEKATLAAVDWTLTKMDSVI--PK-RPQFKPLKIIQRYHFS 631
                 :|..|.:.:....||  |.::||.|          .|:|  || :......|:::.:.|.
Yeast   434 -----MLTACLAASRKKKGL--DAIDKAFL----------KSLIEYPKAKDALTKYKVLEFHPFD 481

  Fly   632 SALKRMSVLAGHLIPYSNEVKHIGAVKGAPEVIQKMLRE---VPAD----YEKVYLEYARRGARV 689
            ...|:::.     :..|.|.:.|..|||||..:.|.:.|   :|.|    ||....|.|.||.|
Yeast   482 PVSKKVTA-----VVESPEGERIVCVKGAPLFVLKTVEEDHPIPEDVHENYENKVAELASRGFR- 540

  Fly   690 LALGIKDLGTLGAQRVREMKREEVECDLTFAGFLIISCPMKPDSKSVIKELIQSSHKVVMITGDS 754
             |||:            ..||.|...::  .|.:....|.:.|:...|.|......::.|:|||:
Yeast   541 -ALGV------------ARKRGEGHWEI--LGVMPCMDPPRDDTAQTINEARNLGLRIKMLTGDA 590

  Fly   755 PLTACHVARELRFTRKKLIILTPPEEDRKNNWSWVSIDGDQSYELD--------TKPGSKKLSHL 811
            ...|....|:|..                         |...|..:        ..|||:
Yeast   591 VGIAKETCRQLGL-------------------------GTNIYNAERLGLGGGGDMPGSE----- 625

  Fly   812 LATHDLCITGEGLQYLQQNQPQYMRQLLPQITVCARFAPKQKELVITQLKQLGYCTLMCGDGTND 876
            ||  |.....:|.                     |...|:.|..|:..|:..||...|.|||.||
Yeast   626 LA--DFVENADGF---------------------AEVFPQHKYRVVEILQNRGYLVAMTGDGVND 667

  Fly   877 VGALKHANVGVSLLTSAPVKRKRTEEEQQQAAANAAAIA--AQAQANANQQLTTRERALRRRQEH 939
            ..:||.|:.|:::            |....||.:||.|.  |...:.....|.|..:...|...:
Yeast   668 APSLKKADTGIAV------------EGATDAARSAADIVFLAPGLSAIIDALKTSRQIFHRMYSY 720

  Fly   940 --------------LNQTQARLQNALRDMEEQTMVKL----GDASIA---APFTSK--------- 974
                          |....|.|.|:| |:.....:.:    ...:||   ||:..:
Yeast   721 VVYRIALSLHLEIFLGLWIAILNNSL-DINLIVFIAIFADVATLTIAYDNAPYAPEPVKWNLPRL 784

  Fly   975 -SSSIMCVNHIIKQGRCTLVTTLQMFKILALNALIQAYCQSVLYIDGIKFSDTQATMQGIFIAAC 1038
             ..||: :..::..|....:||:    .|....:||.:..    ::|:.|.....|...:
Yeast   785 WGMSII-LGIVLAIGSWITLTTM----FLPNGGIIQNFGA----MNGVMFLQISLTENWL----- 835

  Fly  1039 FLFITRAK--------------PLKTLSKVAPLPNIFNFYT------ISTI------LSQFAVHF 1077
             :|:|||.              .:..:..:|.:..:|.:::      :|.:      :..|.| .
Yeast   836 -IFVTRAAGPFWSSIPSWQLAGAVFAVDIIATMFTLFGWWSENWTDIVSVVRVWIWSIGIFCV-L 898

  Fly  1078 GTLYYL--TSQA 1087
            |..||:  ||||
Yeast   899 GGFYYIMSTSQA 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6230	NP_609490.1	P-ATPase-V	109..1193	CDD:273738	210/987 (21%)
		E1-E2_ATPase	310..515	CDD:278548	47/214 (22%)
		Cation_ATPase	<590..664	CDD:289987	19/76 (25%)
		COG4087	<850..901	CDD:226572	16/50 (32%)
PMA2	NP_015289.1	P-type_ATPase_H	116..903	CDD:319771	201/970 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910