DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6230 and ATP13A1

DIOPT Version :9

Sequence 1:	NP_609490.1	Gene:	CG6230 / 34546	FlyBaseID:	FBgn0027582	Length:	1225	Species:	Drosophila melanogaster
Sequence 2:	NP_065143.2	Gene:	ATP13A1 / 57130	HGNCID:	24215	Length:	1204	Species:	Homo sapiens

Alignment Length:	1248	Identity:	643/1248 - (51%)
Similarity:	843/1248 - (67%)	Gaps:	76/1248 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTEAAGATN--PGGAA-------GDAESYGKEMALQSGRPKEPTKLDDLVQYVSLHVRIPTPLTG 56
            |..||...|  |.||.       |..:...:..||.:..|......|:||..|..:.|:......
Human     1 MAAAAAVGNAVPCGARPCGVRPDGQPKPGPQPRALLAAGPALIANGDELVAAVWPYRRLALLRRL 65

  Fly    57 VVLPFVPLYLSAFYLWINVTG------GQENDTTNNDVITADNQTTTDNITTWNDVGFIGVLAIA 115
            .||||..|...|   |:....      |                      ::|..:....:|.:|
Human    66 TVLPFAGLLYPA---WLGAAAAGCWGWG----------------------SSWVQIPEAALLVLA 105

  Fly   116 FL---HILTLLFCYWSVHVLAFLTCRRVKLPGANVLAKVVPTPNNGNSKIVPIRSSKLEDGSTQY 177
            .:   |.||:|..:||||....|||.....|......|||||||||::::|.:..::.|||....
Human   106 TICLAHALTVLSGHWSVHAHCALTCTPEYDPSKATFVKVVPTPNNGSTELVALHRNEGEDGLEVL 170

  Fly   178 YFVFQKTKYVWNE-DRKTFRAVEFPVNGLLSTYSSSRGLETEEDIKRATQTYGNNEMEMVVPEFH 241
            .|.|||.||.::. ::|.|..|.|||....|.|.|:||.:.:.:|:.|.:.:|:|:.|||||:|.
Human   171 SFEFQKIKYSYDALEKKQFLPVAFPVGNAFSYYQSNRGFQEDSEIRAAEKKFGSNKAEMVVPDFS 235

  Fly   242 ELFIERATAPFFVFQVFSVGLWCMDDYWYYSLFTLFMLIAFECTIVKQQLRNMSEIRKMGNKPYL 306
            |||.|||||||||||||.|||||:|:|||||:|||.||:|||.::|:||:|||||||||||||::
Human   236 ELFKERATAPFFVFQVFCVGLWCLDEYWYYSVFTLSMLVAFEASLVQQQMRNMSEIRKMGNKPHM 300

  Fly   307 IYAFRQNKWRHLGSDELLPGDLVSITRSQNDNIVPCDLVILRGSCIVDESMLTGESVPLMKESLE 371
            |..:|..|||.:.|||::|||:|||.||..:|:||||:::|||.|||||:||||||||.|||.:|
Human   301 IQVYRSRKWRPIASDEIVPGDIVSIGRSPQENLVPCDVLLLRGRCIVDEAMLTGESVPQMKEPIE 365

  Fly   372 SLDNLDVEMDAEGDGKLFVLFGGTKVVQHTAPTKES--LRAPDGGCIGYVIRTGFNTSQGKLLRT 434
            .| :.|..:|.:.|.:|.|:|||||||||..|.|.:  |:..|.||:.||:||||||||||||||
Human   366 DL-SPDRVLDLQADSRLHVIFGGTKVVQHIPPQKATTGLKPVDSGCVAYVLRTGFNTSQGKLLRT 429

  Fly   435 ILFGANRATENNVETFAFIAFLMVFAVAAASYVWVKGSEDPERNRYKLFLECTLILTSIIPPDLP 499
            ||||..|.|.||:|||.||.||:|||:|||:|||::|::||.||||||||||||||||::||:||
Human   430 ILFGVKRVTANNLETFIFILFLLVFAIAAAAYVWIEGTKDPSRNRYKLFLECTLILTSVVPPELP 494

  Fly   500 IELTLAVNTSLIQLTKLFVFCTEPFRIPFAGKVQICCFDKTGTLTTDNLMVEGIAGLAPNGACVP 564
            |||:||||||||.|.||:::|||||||||||||::||||||||||:|:|:|.|:|||.......|
Human   495 IELSLAVNTSLIALAKLYMYCTEPFRIPFAGKVEVCCFDKTGTLTSDSLVVRGVAGLRDGKEVTP 559

  Fly   565 IEKAEGNTVQVLACCHSLALLDDG-LVGDPLEKATLAAVDWTLTKMDSVIPKRPQFKPLKIIQRY 628
            :......|.:.||.||||..|||| |||||||||.|.||||||||.:.|.|:..:.:.|||.||:
Human   560 VSSIPVETHRALASCHSLMQLDDGTLVGDPLEKAMLTAVDWTLTKDEKVFPRSIKTQGLKIHQRF 624

  Fly   629 HFSSALKRMSVLAGHLIPYSNEVKHIGAVKGAPEVIQKMLREVPADYEKVYLEYARRGARVLALG 693
            ||:||||||||||.:....|.::.:|.|||||||.:..|..:.|.||..::.|.:|.||||||||
Human   625 HFASALKRMSVLASYEKLGSTDLCYIAAVKGAPETLHSMFSQCPPDYHHIHTEISREGARVLALG 689

  Fly   694 IKDLGTLGAQRVREMKREEVECDLTFAGFLIISCPMKPDSKSVIKELIQSSHKVVMITGDSPLTA 758
            .|:||.|..|:.||:|||.:||.|.|.||:::|||:|.|||:||:|:..:||:|||||||:||||
Human   690 YKELGHLTHQQAREVKREALECSLKFVGFIVVSCPLKADSKAVIREIQNASHRVVMITGDNPLTA 754

  Fly   759 CHVARELRFTRK-KLIILTPPEEDRKNNWSWVSIDGDQSYELDTKPGSKKLSHLLATHDLCITGE 822
            ||||:||.|..| ..:||.||.| :.....|.||||  |..|....||.|.  |...:.||:||:
Human   755 CHVAQELHFIEKAHTLILQPPSE-KGRQCEWRSIDG--SIVLPLARGSPKA--LALEYALCLTGD 814

  Fly   823 GLQYLQQNQPQYMRQLLPQITVCARFAPKQKELVITQLKQLGYCTLMCGDGTNDVGALKHANVGV 887
            ||.:||...||.:.:|:|.:.|.||.||||||.|||.||:|||.|||||||||||||||||:|||
Human   815 GLAHLQATDPQQLLRLIPHVQVFARVAPKQKEFVITSLKELGYVTLMCGDGTNDVGALKHADVGV 879

  Fly   888 SLLTSAP---VKRKRTEEEQQQAAANAAAIAAQAQANANQQLTTRERA-LRRRQEHLNQTQARLQ 948
            :||.:||   |:|:|  ..:.....:.:.|.|.::       |.::|: |...:|.....:.||.
Human   880 ALLANAPERVVERRR--RPRDSPTLSNSGIRATSR-------TAKQRSGLPPSEEQPTSQRDRLS 935

  Fly   949 NALRDMEEQT--MVKLGDASIAAPFTSKSSSIMCVNHIIKQGRCTLVTTLQMFKILALNALIQAY 1011
            ..|||:|:::  :|||||||||||||||.|||.|:.|:||||||||||||||||||||||||.||
Human   936 QVLRDLEDESTPIVKLGDASIAAPFTSKLSSIQCICHVIKQGRCTLVTTLQMFKILALNALILAY 1000

  Fly  1012 CQSVLYIDGIKFSDTQATMQGIFIAACFLFITRAKPLKTLSKVAPLPNIFNFYTISTILSQFAVH 1076
            .|||||::|:||||.|||:||:.:|.|||||:|:|||||||:..|||||||.|||.|::.||.||
Human  1001 SQSVLYLEGVKFSDFQATLQGLLLAGCFLFISRSKPLKTLSRERPLPNIFNLYTILTVMLQFFVH 1065

  Fly  1077 FGTLYYLTSQANILAPPREGKVKLYIDMDAEEKTKYDPNIVSSTVYIICLSLQVATIAVNYKGYP 1141
            |.:|.||..:|...:|.::   :.::|:..|    ::|::|:|||||:.:::|:||.|:||||.|
Human  1066 FLSLVYLYREAQARSPEKQ---EQFVDLYKE----FEPSLVNSTVYIMAMAMQMATFAINYKGPP 1123

  Fly  1142 FMESLRSNRMLMYAIGASAALVILLSTGLAPELTEFFEIIDFPTDFRKTLLGVLVLDIVGAFLLD 1206
            |||||..|:.|::::..|...:|.|..|.:|:....|.::|.|.:|:..:..||:||...|.|.|
Human  1124 FMESLPENKPLVWSLAVSLLAIIGLLLGSSPDFNSQFGLVDIPVEFKLVIAQVLLLDFCLALLAD 1188

  Fly  1207 RICSFLFGETRRK 1219
            |:..|..|..:.|
Human  1189 RVLQFFLGTPKLK 1201

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6230	NP_609490.1	P-ATPase-V	109..1193	CDD:273738	607/1097 (55%)
		E1-E2_ATPase	310..515	CDD:278548	136/206 (66%)
		Cation_ATPase	<590..664	CDD:289987	45/73 (62%)
		COG4087	<850..901	CDD:226572	40/53 (75%)
ATP13A1	NP_065143.2	P-ATPase-V	85..1173	CDD:273738	609/1131 (54%)
		A-domain, part 1. /evidence=ECO:0000250\|UniProtKB:P39986	199..230		10/30 (33%)
		A-domain, part 2. /evidence=ECO:0000250\|UniProtKB:P39986	295..435		86/140 (61%)
		E1-E2_ATPase	298..510	CDD:278548	138/212 (65%)
		P-domain, part 1. /evidence=ECO:0000250\|UniProtKB:P39986	512..541		23/28 (82%)
		N-domain. /evidence=ECO:0000250\|UniProtKB:P39986	543..724		95/180 (53%)
		Cation_ATPase	584..667	CDD:289987	47/82 (57%)
		HAD	643..873	CDD:289480	128/234 (55%)
		P-domain, part 2. /evidence=ECO:0000250\|UniProtKB:P39986	727..885		94/162 (58%)
		COG4087	<831..>884	CDD:226572	40/52 (77%)
		Arm-like. /evidence=ECO:0000250\|UniProtKB:P39986	886..949		16/71 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	889..933		9/52 (17%)
		P-domain, part 3. /evidence=ECO:0000250\|UniProtKB:P39986	950..965		14/14 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156409
Domainoid	1	1.000	405	1.000	Domainoid score	I718
eggNOG	1	0.900	-	-		E2759_KOG0209
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5791
Inparanoid	1	1.050	1191	1.000	Inparanoid score	I193
Isobase	1	0.950	-	0	Normalized mean entropy	S925
OMA	1	1.010	-	-		QHG54176
OrthoDB	1	1.010	-	-		D172453at2759
OrthoFinder	1	1.000	-	-		FOG0005171
OrthoInspector	1	1.000	-	-		oto90662
orthoMCL	1	0.900	-	-		OOG6_101914
Panther	1	1.100	-	-	LDO	PTHR45630
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R100
SonicParanoid	1	1.000	-	-		X3689
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750