DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6230 and atp2a3

DIOPT Version :9

Sequence 1:	NP_609490.1	Gene:	CG6230 / 34546	FlyBaseID:	FBgn0027582	Length:	1225	Species:	Drosophila melanogaster
Sequence 2:	XP_697108.5	Gene:	atp2a3 / 568671	ZFINID:	ZDB-GENE-060531-103	Length:	1005	Species:	Danio rerio

Alignment Length:	819	Identity:	192/819 - (23%)
Similarity:	310/819 - (37%)	Gaps:	198/819 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 EDRKTFRAVE----FPVNGLLSTYSSSRGLETEEDIKRATQTYGNNEM---------EMVVPEFH 241
            |:..|..|.|    |.||       .:.|| |.|.:|.....||.||:         |:||.:|.
Zfish     2 ENAHTKSASEVLANFGVN-------ENTGL-TLEQVKNNFDKYGPNELPAEEGKSLWELVVEQFE 58

  Fly   242 ELFIE---RATAPFFVFQVFSVGLWCMDDYWYYSLFTLFMLIAFECTIVKQQLRNMSEIRKMGN- 302
            :|.:.   .|....||..:|..|......: ...:..|.:|:|.....|.|:....:.|..:..
Zfish    59 DLLVRILLLAACVSFVLALFEEGEESTTAF-VEPIVILLILVANAVIGVWQERNAENAIEALKEY 122

  Fly   303 KPYLIYAFRQNKW--RHLGSDELLPGDLVSITRSQNDNIVPCDLVI--LRGSCI-VDESMLTGES 362
            :|.:...:|.|:.  :.:.:.:::|||:|.|  |..|. ||.|:.|  ::.:.: ||:|:|||||
Zfish   123 EPEMGKVYRMNRTAVQRIKARDIVPGDIVEI--SVGDK-VPADIRITSIKSTTLRVDQSILTGES 184

  Fly   363 VPLMKESLESLDNLDVEMDAEGDGKLFVLFGGTKVVQHTAPTKESLRAPDGGCIGYVIRTGFNTS 427
            |.::|.:....|...|..|     |..:||.||.:..             |..||.|:.||.:|.
Zfish   185 VSVIKHTDPVPDPRAVNQD-----KKNMLFSGTNIAA-------------GRAIGVVVSTGVSTE 231

  Fly   428 QGKLLRTILFGANRAT--ENNVETFAFIAFLMVFAVAAASYV--------------WVKGSEDPE 476
            .||:...:.......|  :..::.|......::..:..|.:|              |::|:
Zfish   232 IGKIRNQMAATEQEKTPLQQKLDEFGQQLSKVISLICIAVWVINIGHFADPVHGGSWIRGA---- 292

  Fly   477 RNRYKLFLECTLILTSIIPPDLPIELTLAVNTSLIQLTKLFVFCTEPFRIPFAGKVQICCFDKTG 541
               ...|.....:..:.||..||..:|..:.....::.|..........:...|...:.|.||||
Zfish   293 ---IYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTG 354

  Fly   542 TLTTDNLMV--EGIAGLAPNGACVPIE-KAEGNTV----QVLACCHSLALLD-DGLVGDPLEKAT 598
            ||||:.:.|  ..:...|.:.:|...| ...|:|.    :||.....:...| ||||    |.||
Zfish   355 TLTTNQMSVCRMFVVNKADDSSCSLHEFTISGSTYAPEGEVLKADKQVQCGDYDGLV----ELAT 415

  Fly   599 L------AAVDW-------------TLTKMDSVIPKRPQFKP------------------LKIIQ 626
            :      :::|:             |.|.:.:::.|...||.                  .:::|
Zfish   416 ICSLCNDSSLDYNEAKGVYEKVGEATETALTTLVEKMNVFKTDLSGLSKVDRAAACNLIIRQLMQ 480

  Fly   627 R---YHFSSALKRMSVLAGHLIPYSNEVKHIGAVKGAPEVIQKMLREVPADYEKVYLEYA----- 683
            :   ..||...|.|||   :..|.....:....||||||.:....:.|....|:..|..|
Zfish   481 KKFTLEFSRDRKSMSV---YCTPNGTNSQSKMFVKGAPEGVIDRCQFVRVGKERFPLTMAVKEEL 542

  Fly   684 ----------RRGARVLALGIKDLGTLGAQRVREMKRE------EVECDLTFAGFLIISCPMKPD 732
                      |...|.|||..:|    ....|.:|..|      |.|..|||.|.:.:..|.:.:
Zfish   543 MSTIRDWGTGRDTLRCLALATRD----SPPAVDKMDLENAGKFAEYESSLTFVGCVGMLDPPRKE 603

  Fly   733 SKSVIKELIQSSHKVVMITGDSPLTACHVARELRFTRKKLIILTPPEEDRKNNWSWVSIDGDQSY 797
            ....||...::..:|:|||||:..||..:.|.        |.:....||         ::| ::|
Zfish   604 VIGSIKLCNKAGIRVIMITGDNKGTAVAICRR--------IGIFSENED---------VEG-RAY 650

  Fly   798 ELDTKPGSKKLSHLLATHDLCITGEGLQYLQQNQPQYMRQLLPQITVCARFAPKQKELVITQLKQ 862
                                  ||.....|   .|:..|:.:.:....||..|..|..::..|:.
Zfish   651 ----------------------TGREFDDL---APEAQREAVKRARCFARVEPAHKSKIVAYLQS 690

  Fly   863 LGYCTLMCGDGTNDVGALKHANVGVSLLTSAPVKRKRTE 901
            ....|.|.|||.||..|||.|.:|:::.:...|.:..:|
Zfish   691 FDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSASE 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6230	NP_609490.1	P-ATPase-V	109..1193	CDD:273738	192/819 (23%)
		E1-E2_ATPase	310..515	CDD:278548	52/225 (23%)
		Cation_ATPase	<590..664	CDD:289987	24/113 (21%)
		COG4087	<850..901	CDD:226572	16/50 (32%)
atp2a3	XP_697108.5	Cation_ATPase_N	4..72	CDD:279080	21/75 (28%)
		ATPase-IIA1_Ca	53..986	CDD:273452	175/760 (23%)
		E1-E2_ATPase	92..340	CDD:278548	60/275 (22%)
		Cation_ATPase	419..525	CDD:289987	20/108 (19%)
		HAD	<601..709	CDD:289480	34/150 (23%)
		Cation_ATPase_C	781..984	CDD:279079
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910