DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6230 and atp13a2

DIOPT Version :9

Sequence 1:	NP_609490.1	Gene:	CG6230 / 34546	FlyBaseID:	FBgn0027582	Length:	1225	Species:	Drosophila melanogaster
Sequence 2:	NP_001073506.1	Gene:	atp13a2 / 568666	ZFINID:	ZDB-GENE-061215-126	Length:	1170	Species:	Danio rerio

Alignment Length:	1209	Identity:	319/1209 - (26%)
Similarity:	524/1209 - (43%)	Gaps:	236/1209 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 AIAFLHILTLLFCYWSVHVLAFLTCRRVKLPGANVLAKVVPTPNNGNSKIVPIRSSKLEDGSTQY 177
            |:..:.:|.:|| .|...:.....|:...:..|:||   :.....|...:|.:.:.::|:||..:
Zfish    57 AVFSVGLLLVLF-KWRPRIGILARCKSCPISMADVL---LLKDRYGQQFVVDVITEEVEEGSLDF 117

  Fly   178 -------------------------YFVFQKTKYVWNEDRKTFRAVEFPVNG--LLSTYSSSRGL 215
                                     |:||:..:|:|...:..|........|  ....:...:||
Zfish   118 AVGDADENEWRDTVQLHSEKKTLLRYYVFEGIRYIWISKKGAFCKASVLSEGWTCADLHGQQQGL 182

  Fly   216 ETEEDIKRATQTYGNNEMEMVVPEFHELFIERATAPFFVFQVFSVGLWCMDDYWYYSLFTLFMLI 280
            ...:...| .|.:|.|.:::.|..:.:|..|....||::|||||:.||..|.|.||:. .:|::.
Zfish   183 SRADQSTR-KQIFGANIIDVPVKSYLQLLFEEVLNPFYIFQVFSIILWMSDGYVYYAA-CIFIIS 245

  Fly   281 AFECTIVKQQLRNMS-EIRKMGNKPYLIYAFRQ-NKWRHLGSDELLPGDLVSITRSQNDNIVPCD 343
            .....:...:.|..| .:|:|......:...|. .:...:.|:||:|||.|.|  .....::|||
Zfish   246 LISIGVSLYETRKQSTTLRRMACLIVNVTVRRDTGEEECVSSEELVPGDCVVI--PAEGLLLPCD 308

  Fly   344 LVILRGSCIVDESMLTGESVPLMKESLESLDNLDVEMDAEGDGKLFVLFGGTKVVQHTAPTKESL 408
            ..::.|.|:|:||||||||:|:||   ..|.|.:...:.|.. :...||.||:::|...
Zfish   309 AALVAGECMVNESMLTGESIPVMK---TPLSNSEATYNPESQ-RRHTLFCGTQIIQAKG------ 363

  Fly   409 RAPDGGCIGYVIRTGFNTSQGKLLRTILFGANRATENNVETFAFIAFLMVFAVAAASY--VWVKG 471
            ..|..|.|..|..|||.|::|.|:.:||:..........:...|:.||.:.|:....|  |.:..
Zfish   364 GGPGKGAIAVVTCTGFLTAKGDLISSILYPQPLDFRFYRDAMKFLLFLGLLALIGTIYSLVILSK 428

  Fly   472 SEDPERNRYKLFLECTLILTSIIPPDLPIELTLAVNTSLIQLTKLFVFCTEPFRIPFAGKVQICC 536
            |..|.:   :|.:....|:|.|:||.||..:|.|...:..:|.:..|||..|.||...||:.:.|
Zfish   429 SNTPWK---ELIIRSLDIVTIIVPPALPAAITTATIYAQNRLKRQGVFCISPPRINICGKISLFC 490

  Fly   537 FDKTGTLTTDNLMVEGI--------AGLAPNGACVPIEKAEGNTVQVLACCHSLALLDDGLVGDP 593
            ||||||||.:.|.|.|:        ..|.|:    |:....|..:..||.|||:|||....:|||
Zfish   491 FDKTGTLTEEGLDVWGVMEVTGGVFGELVPD----PLFLPPGLMLSALASCHSVALLGGQALGDP 551

  Fly   594 LEKATLAAVDWTLTKMDSVIPKRPQF------------------------KPLKIIQRYHFSSAL 634
            ||...:.:..|.||:.::.:....:|                        :|:.|::|:.|||:|
Zfish   552 LELKMIESTGWELTEPENDMGHDSEFGGHRVLAVMRPPASELLTEGNSVSQPVAIVRRFPFSSSL 616

  Fly   635 KRMSVL-AGHLIPYSNEVKHIGAVKGAPEVIQKMLRE--VPADYEKVYLEYARRGARVLALGIK- 695
            :||||: .|...|     ..:..:|||||::.....:  ||:.:.....|||.:|.|||.|..|
Zfish   617 QRMSVVTVGPAEP-----SPVAFIKGAPEMVASFCHKESVPSHFSHTLREYASQGFRVLGLAYKH 676

  Fly   696 -----DLGTLGAQRVREMKREEVECDLTFAGFLIISCPMKPDSKSVIKELIQSSHKVVMITGDSP 755
                 ||.|        ::|.|||..:.|.|.|::...:||:|..||:.|..:..:.||:|||:.
Zfish   677 LAKETDLST--------VERVEVEKGMNFLGLLVMKNQVKPESAEVIQTLTLAQLRPVMVTGDNI 733

  Fly   756 LTACHVARELRFT--RKKLIIL--TPPE-------EDRKNNWSWVSIDGDQSYELDTKPGSKKLS 809
            |||.:|||.....  .:|:|.:  :||.       :..:...:..:|:..|:.::   |...:..
Zfish   734 LTAVNVARVCGMVPLHEKVIFVHASPPTAGSQASLQFHEGEGATATINTQQTIDI---PVQGQYQ 795

  Fly   810 HLLATHDLCITGEGLQYLQQNQPQYMRQLLPQITVCARFAPKQKELVITQLKQLGYCTLMCGDGT 874
            ..:..| |.|.|.....|..:.|:|:.::|.:.|:.||..|:||..::..|::|.|...|||||.
Zfish   796 SAVGYH-LAINGMSFAALCDHFPEYLPKVLMRGTIYARMTPEQKTQLVKALQKLNYRVGMCGDGA 859

  Fly   875 NDVGALKHANVGVSLLTSAPVKRKRTEEEQQQAAANAAAIAAQAQANANQQLTTRERALRRRQEH 939
            ||.|||:.|:|||||..:
Zfish   860 NDCGALRAADVGVSLSDA----------------------------------------------- 877

  Fly   940 LNQTQARLQNALRDMEEQTMVKLGDASIAAPFTSKSSSIMCVNHIIKQGRCTLVTTLQMFKILAL 1004
                                    :||:|:||||||.:|.||..:||:|||:|||:..:||.:||
Zfish   878 ------------------------EASVASPFTSKSDNISCVPLLIKEGRCSLVTSFSLFKYMAL 918

  Fly  1005 NALIQAYCQSVLYIDGIKFSDTQ-ATMQGIFIAACFLFITRAKPLKTLSKVAPLPNIFN------ 1062
            .:|||.....:||.:.....|.| .....:.:....:.:.|..|...|....|..::.:
Zfish   919 YSLIQFASVLILYTEKTNLGDLQFLFFDLVLVTVLAILMGRGGPSNDLHPQRPAASLLSLPVLAS 983

  Fly  1063 --FYTISTILSQFAVHFGTLYYLTSQANI-LAPPREGKVKLYIDMDAEEKTKYDPNIVSSTVYII 1124
              .:|:..||:|.:   |.|..::....: |...|.|...|             ||:..::|:.:
Zfish   984 LLMHTVLLILAQVS---GLLITMSQDWYVPLNSTRTGAANL-------------PNMEDTSVFAV 1032

  Fly  1125 CLSLQVATIAVNYKGYPFMESLRSNRMLMYAIGASAAL---VILLSTGLAPELTEFFEIIDFPTD 1186
            .....:....|..||:|:.:.|..|.:.:.|:....||   ::|....:...:...::|.|.  .
Zfish  1033 SGFQYIIMSVVITKGFPYKKPLYHNVLFVCALVFLFALMSWLVLFRHTIIHRVLSLYDITDM--S 1095

  Fly  1187 FRKTLLGVLVLDIVGAFLLDRICSFLFGETRRKSKVLNC 1225
            ::..|:.:..|:....|||:    |...:     ..|||
Zfish  1096 YKLLLVAIAALNFFICFLLE----FFIDQ-----GALNC 1125

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6230	NP_609490.1	P-ATPase-V	109..1193	CDD:273738	311/1175 (26%)
		E1-E2_ATPase	310..515	CDD:278548	65/207 (31%)
		Cation_ATPase	<590..664	CDD:289987	27/98 (28%)
		COG4087	<850..901	CDD:226572	22/50 (44%)
atp13a2	NP_001073506.1	P5-ATPase	36..152	CDD:289194	17/98 (17%)
		P-ATPase-V	42..1102	CDD:273738	311/1175 (26%)
		Cation_ATPase_N	<179..229	CDD:279080	16/50 (32%)
		E1-E2_ATPase	241..478	CDD:278548	73/251 (29%)
		Cation_ATPase	<606..646	CDD:289987	17/44 (39%)
		HAD_like	<832..885	CDD:304363	26/123 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54176
OrthoDB	1	1.010	-	-		D172453at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.930