DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6230 and Atpalpha

DIOPT Version :9

Sequence 1:	NP_609490.1	Gene:	CG6230 / 34546	FlyBaseID:	FBgn0027582	Length:	1225	Species:	Drosophila melanogaster
Sequence 2:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster

Alignment Length:	748	Identity:	154/748 - (20%)
Similarity:	267/748 - (35%)	Gaps:	221/748 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   254 VFQVFSVGLW-----CM--------------DDYWYYSLFTLFMLIAFECTIVKQQLRNMSEIRK 299
            :|..|::.||     |.              ||..|..:....::|........|:.::...:..
  Fly   114 LFGGFAMLLWIGAILCFVAYSIQASTSEEPADDNLYLGIVLSAVVIVTGIFSYYQESKSSKIMES 178

  Fly   300 MGNK-PYLIYAFRQNKWRHLGSDELLPGDLVSITRSQNDNIVPCDLVILRG-SCIVDESMLTGES 362
            ..|. |......|:.:...|.:::|:.||:|.:.....   :|.|:.|:.. :..||.|.|||||
  Fly   179 FKNMVPQFATVIREGEKLTLRAEDLVLGDVVEVKFGDR---IPADIRIIEARNFKVDNSSLTGES 240

  Fly   363 VPLMKESLESLDNLDVEMDAEGDGKLFVLFGGTKVVQHTAP--TKE----SLRAPDGGCIGYVIR 421
            .|                  :..|..|.         |..|  ||.    |..|.:|...|.||.
  Fly   241 EP------------------QSRGAEFT---------HENPLETKNLAFFSTNAVEGTAKGVVIS 278

  Fly   422 TGFNTSQGKL--LRTILFGANRATENNVE---------------TFAFIAFLMVFAVAAASYVWV 469
            .|.:|..|::  |.:.|..........:.               ||..|||::       .|.|
  Fly   279 CGDHTVMGRIAGLASGLDTGETPIAKEIHHFIHLITGVAVFLGVTFFVIAFIL-------GYHW- 335

  Fly   470 KGSEDPERNRYKLFLECTLILTSIIPPDLPIELTLAVNTSLIQLT-------KLFVFCTEPFRIP 527
                          |:..:.|..||..::| |..||..|..:.||       ...|...|  .:.
  Fly   336 --------------LDAVIFLIGIIVANVP-EGLLATVTVCLTLTAKRMASKNCLVKNLE--AVE 383

  Fly   528 FAGKVQICCFDKTGTLTT----------DNLMVEGIAGLAPNGACVPIEKAEGN---TVQVLACC 579
            ..|.....|.|||||||.          ||.::|  |....:.:.|..::....   ..::...|
  Fly   384 TLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIE--ADTTEDQSGVQYDRTSPGFKALSRIATLC 446

  Fly   580 H---------SLALLDDGLVGDPLEKATLAAVDWTLTKMDSVIPKRPQFKPLKIIQRYHFSSALK 635
            :         .:.:|...:.||..|.|.|..::..|..:.::..:.      |.|....|:|..|
  Fly   447 NRAEFKGGQDGVPILKKEVSGDASEAALLKCMELALGDVMNIRKRN------KKIAEVPFNSTNK 505

  Fly   636 -RMSVLAGHLIPYSNEVKHIGAVKGAPEVI------------QKML-REVPADYEKVYLEYARRG 686
             ::|:   |....:|:.:::..:|||||.|            :|:| .|:...:...|:|....|
  Fly   506 YQVSI---HETEDTNDPRYLLVMKGAPERILERCSTIFINGKEKVLDEEMKEAFNNAYMELGGLG 567

  Fly   687 ARVLAL------------GIKDLGTLGAQRVREMKREEVEC---DLTFAGFLIISCPMKPDSKSV 736
            .|||..            |.|            ...:::..   :|.|.|.:.:..|.:......
  Fly   568 ERVLGFCDFMLPSDKYPNGFK------------FNTDDINFPIDNLRFVGLMSMIDPPRAAVPDA 620

  Fly   737 IKELIQSSHKVVMITGDSPLTACHVARELRFTRKKLIILTPPEEDRKNNWSWVSIDGDQSYE--- 798
            :.:...:..||:|:|||.|:||..:|:.:                      .:..:|:::.|
  Fly   621 VAKCRSAGIKVIMVTGDHPITAKAIAKSV----------------------GIISEGNETVEDIA 663

  Fly   799 -------LDTKPGSKKLSHLLATHDLCITGEGLQYLQQNQPQYMRQLLPQITVCARFAPKQKELV 856
                   .:..|...|.:        .:.|..|:.:..:|...:.:...:| |.||.:|:||.::
  Fly   664 QRLNIPVSEVNPREAKAA--------VVHGAELRDVSSDQLDEILRYHTEI-VFARTSPQQKLII 719

  Fly   857 ITQLKQLGYCTLMCGDGTNDVGALKHANVGVSL 889
            :...:::|....:.|||.||..|||.|::||::
  Fly   720 VEGCQRMGAIVAVTGDGVNDSPALKKADIGVAM 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6230	NP_609490.1	P-ATPase-V	109..1193	CDD:273738	154/748 (21%)
		E1-E2_ATPase	310..515	CDD:278548	53/235 (23%)
		Cation_ATPase	<590..664	CDD:289987	19/74 (26%)
		COG4087	<850..901	CDD:226572	15/40 (38%)
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	154/748 (21%)
		Cation_ATPase_N	58..132	CDD:214842	5/17 (29%)
		E1-E2_ATPase	152..383	CDD:278548	59/285 (21%)
		Cation_ATPase	445..539	CDD:289987	22/102 (22%)
		COG4087	<695..770	CDD:226572	20/59 (34%)
		Cation_ATPase_C	817..1025	CDD:279079
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910