Protein Alignment CG6230 and ATP13A5

DIOPT Version :10

• Sequence 1: NP_609490.1
• Gene: CG6230 / 34546
• FlyBaseID: FBgn0027582
• Length: 1225
• Species: Drosophila melanogaster
• Sequence 2: NP_940907.2
• Gene: ATP13A5 / 344905
• HGNCID: 31789
• Length: 1218
• Species: Homo sapiens
• Alignment Length: 1118
• Identity: 312/1118 - (27%)
• Similarity: 504/1118 - (45%)
• Gaps: 213/1118 - (19%)

  Fly   182 QKTKYVWNEDRKTFRAVEFPVNGLLSTYSS--------SRGLETEE-DIKRATQTYGNNEMEMVV 237
            ||.:||||:..|.|:.|     |||...:|        ..||.:|| :::|.  ..|.|.:|:.:
Human   135 QKIRYVWNDLEKRFQKV-----GLLEDSNSCSDIHQTFGLGLTSEEQEVRRL--VCGPNAIEVEI 192

  Fly   238 PEFHELFIERATAPFFVFQVFSVGLWCMDDYWYYSLFTLFM-LIAFECTI--VKQQLRNMSEIRK 299
            ....:|.:::...||:|||.|::.||....|..||:..:.: :|:...::  ::||...:..:.:
Human   193 QPIWKLLVKQVLNPFYVFQAFTLTLWLSQGYIEYSVAIIILTVISIVLSVYDLRQQSVKLHNLVE 257

  Fly   300 MGNKPYLIYAFRQNKWRHLGSDELLPGDLVSITRSQNDNIVPCDLVILRGSCIVDESMLTGESVP 364
            ..||..:....:......|.|..|:|||::.:....:   :|||.|::.|||:|:|.||||||:|
Human   258 DHNKVQVTIIVKDKGLEELESRLLVPGDILILPGKFS---LPCDAVLIDGSCVVNEGMLTGESIP 319

  Fly   365 LMKESLESLDN-LDVEMDAEGDGKLFVLFGGTKVVQHTAPTKESLRAPDGGCIGYVIRTGFNTSQ 428
            :.|..|..::| :..:..:..|.:..|||.||:|:|.....:..:||       .|::||:||::
Human   320 VTKTPLPQMENTMPWKCHSLEDYRKHVLFCGTEVIQVKPSGQGPVRA-------VVLQTGYNTAK 377

  Fly   429 GKLLRTILFGANRATENNVETFAFIAFL-----MVFAVAAASYVWVKGSEDPERNRYKLFLECTL 488
            |.|:|:||:......:...:.|.||.||     |.|..|...|::   ...|.::...:.|   :
Human   378 GDLVRSILYPRPLNFKLYSDAFKFIVFLACLGVMGFFYALGVYMY---HGVPPKDTVTMAL---I 436

  Fly   489 ILTSIIPPDLPIELTLAVNTSLIQLTKLFVFCTEPFRIPFAGKVQICCFDKTGTLTTDNLMVEGI 553
            :||..:||.||..||:....:..:|.|..:||..|.||...|::.:.|||||||||.|.|.:.|.
Human   437 LLTVTVPPVLPAALTIGNVYAQKRLKKKKIFCISPQRINMCGQINLVCFDKTGTLTEDGLDLWGT 501

  Fly   554 AGLAPNGACVPIEKAEGNTV------QVLACCHSLALLDDGLVGDPLEKATLAAVDWTL------ 606
            ...|.|........|.|..|      ..:|.||||.||:..:.||||:........|.:
Human   502 VPTADNCFQEAHSFASGQAVPWSPLCAAMASCHSLILLNGTIQGDPLDLKMFEGTAWKMEDCIVD 566

  Fly   607 -----TKMDSVIPKRPQF--KPLKII---QRYHFSSALKRMSVLA-----GHLIPYSNEVKHIGA 656
                 |.:.::|...|:.  .|::.|   .::.|||:|:||||:|     .|...|
Human   567 SCKFGTSVSNIIKPGPKASKSPVEAIITLCQFPFSSSLQRMSVIAQLAGENHFHVY--------- 622

  Fly   657 VKGAPEVIQKMLRE--VPADYEKVYLEYARRGARVLALGIKDLGTLGAQRVREMKREEVECDLTF 719
            :|||||::.:..|.  ||.::.:....|..:|.||:||..|.|.......|..:.||:||.:|||
Human   623 MKGAPEMVARFCRSETVPKNFPQELRSYTVQGFRVIALAHKTLKMGNLSEVEHLAREKVESELTF 687

  Fly   720 AGFLIISCPMKPDSKSVIKELIQSSHKVVMITGDSPLTACHVAR--ELRFTRKKLIIL--TPPEE 780
            .|.||:...:|.::|.|:|||.::..:.||||||:..||..||:  |:.....::||:  ..|||
Human   688 LGLLIMENRLKKETKLVLKELSEARIRTVMITGDNLQTAITVAKNSEMIPPGSQVIIVEADEPEE 752

  Fly   781 DRKNNWSWVSIDGDQSYELDTKPGSKKLSHLLATHDLCITGEG---LQYLQQNQP-----QYMRQ 837
            ....:.:|..::..     :|.||.|:: ::...:.....|||   ..:....:.     |:...
Human   753 FVPASVTWQLVENQ-----ETGPGKKEI-YMHTGNSSTPRGEGGSCYHFAMSGKSYQVIFQHFNS 811

  Fly   838 LLPQI----TVCARFAPKQKELVITQLKQLGYCTLMCGDGTNDVGALKHANVGVSLLTSAPVKRK 898
            |||:|    ||.||.:|.||..:|.:.::|.|...|||||.||.||||.|:.|:||
Human   812 LLPKILVNGTVFARMSPGQKSSLIEEFQKLNYYVGMCGDGANDCGALKAAHAGISL--------- 867

  Fly   899 RTEEEQQQAAANAAAIAAQAQANANQQLTTRERALRRRQEHLNQTQARLQNALRDMEEQTMVKLG 963
             :|:|
Human   868 -SEQE------------------------------------------------------------ 871

  Fly   964 DASIAAPFTSKSSSIMCVNHIIKQGRCTLVTTLQMFKILALNALIQAYCQSVLYIDGIKFSDTQA 1028
             ||:|:|||||:::|.||.|:|::||..||::..:||.|.:..:||.....:||.....|.:.|.
Human   872 -ASVASPFTSKTTNIQCVPHLIREGRAALVSSFGVFKYLTMYGIIQFISALLLYWQLQLFGNYQY 935

  Fly  1029 TMQGIFIA--ACF-LFITRAKPLKTLSKVAPLPNIFNFYTISTILSQF-------AVHFGTLYYL 1083
            .||.:.|.  .|. :..|.|.|     |:||........:...:||.|       .|......|:
Human   936 LMQDVAITLMVCLTMSSTHAYP-----KLAPYRPAGQLLSPPLLLSIFLNSCFSCIVQISAFLYV 995

  Fly  1084 TSQANILAPPREGKVKLYIDMDAEEKTKYDPNIV-----SSTVYII---CLSLQVATI----AVN 1136
            ..|      |...:|..|.:.....::.:..|:.     :....:|   .||.:..|:    .:|
Human   996 KQQ------PWYCEVYQYSECFLANQSNFSTNVSLERNWTGNATLIPGSILSFETTTLWPITTIN 1054

  Fly  1137 Y--------KGYPFMESLRSNRMLMYAIGASAALVILLSTGLAPELTEFFEIIDFPTDFRKTLLG 1193
            |        ||.||.:.:.:|.:..:.:.|:..|.|.:.......:....|:|...|.:|..:|.
Human  1055 YITVAFIFSKGKPFRKPIYTNYIFSFLLLAALGLTIFILFSDFQVIYRGMELIPTITSWRVLILV 1119

  Fly  1194 VLVLDIVGAFLLD 1206
            |.:.....||.::
Human  1120 VALTQFCVAFFVE 1132

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6230	NP_609490.1	P-type_ATPase_cation	220..1152	CDD:319843	284/1015 (28%)
ATP13A5	NP_940907.2	P5-ATPase	17..142	CDD:463565	4/6 (67%)
		P-type_ATPase_cation	174..1001	CDD:319842	272/941 (29%)