DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6230 and Atp13a5

DIOPT Version :9

Sequence 1:	NP_609490.1	Gene:	CG6230 / 34546	FlyBaseID:	FBgn0027582	Length:	1225	Species:	Drosophila melanogaster
Sequence 2:	XP_038944228.1	Gene:	Atp13a5 / 303856	RGDID:	1306792	Length:	1237	Species:	Rattus norvegicus

Alignment Length:	1255	Identity:	328/1255 - (26%)
Similarity:	537/1255 - (42%)	Gaps:	291/1255 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 VLAIAFLHILTLLFCYWSVHVLAFLTCRRVKLPGANVL-------------AKV---------VP 153
            |.||..|..:.|:| ||......:.:|....|..|:::             .||         :|
  Rat    38 VTAILTLGAVQLMF-YWRPEWWVWTSCIPCPLQEADIVLLRTTDEFRRYMRKKVFCLHLSTLKIP 101

  Fly   154 TPNNGNSKIVP-----IRSSKLEDGSTQYYFVFQKTKYVWNEDRKTFRAVEFPVNGLLSTYSS-- 211
            ...|....:|.     |..:.::..........||.:|||:..:|.|:.|     |||...:|
  Rat   102 ISKNPGEPLVADHHSVINQAVMKPELKLRCIQVQKIRYVWDFLKKRFQKV-----GLLEDSNSCF 161

  Fly   212 ------SRGLETEE-DIKRATQTYGNNEMEMVVPEFHELFIERATAPFFVFQVFSVGLWCMDDYW 269
                  ..||.:|| :::|.  ..|.|.:|:.:....:|.:::...||:|||.|::.||....|.
  Rat   162 DIHHTFGLGLTSEEQEVRRL--VCGPNAIEVEIQPIWKLLVKQVLNPFYVFQAFTLTLWLSQGYI 224

  Fly   270 YYSLFTLFM-LIAFECTI--VKQQLRNMSEIRKMGNKPYLIYAFRQNKWRHLGSDELLPGDLVSI 331
            .||:..:.: :|:...::  ::||...:.::.:..||..:....|....:.|.|..|:|||::.:
  Rat   225 EYSVAIIILTVISIVLSVYDLRQQSVKLHKLVEDHNKVQVTITVRDKGLQELESRLLVPGDILIL 289

  Fly   332 TRSQNDNIVPCDLVILRGSCIVDESMLTGESVPLMKESLESLDN-LDVEMDAEGDGKLFVLFGGT 395
            ....:   :|||.|::.|||:|:|.||||||:|:.|..|...:| :..:..:..|.:..|||.||
  Rat   290 PGKIS---LPCDAVLIDGSCVVNEGMLTGESIPVTKTPLPQTENTMPWKSHSLEDYRKHVLFCGT 351

  Fly   396 KVVQHTAPTKESLRAPDGGCIGYVIRTGFNTSQGKLLRTILFGANRATENNVETFAFIAFLMVFA 460
            :|:|.....:..:||       .|::||:||::|.|:|:||:......:...:.|.|:.||....
  Rat   352 EVIQVKPSGQGPVRA-------VVLQTGYNTAKGDLVRSILYPRPLNFKLYNDAFKFMVFLACIG 409

  Fly   461 V-----AAASYVWVKGSEDPERNRYKLFLECTLILTSIIPPDLPIELTLAVNTSLIQLTKLFVFC 520
            |     |...|::   .|.|.|....:.|   ::||:.:||.||..||:....:..:|.|..:||
  Rat   410 VVGFFYALGVYLY---HEVPPRETVTMAL---ILLTATVPPVLPAALTIGNVYAQKRLKKKKIFC 468

  Fly   521 TEPFRIPFAGKVQICCFDKTGTLTTDNLMVEGIAGLAPN----------GACVPIEKAEGNTVQV 575
            ..|.||...|::.:.|||||||||.|.|.:.|....|.|          |..||    .|.....
  Rat   469 ISPQRINMCGQINLVCFDKTGTLTEDGLDLWGTVPTAGNCFQAVHSFASGEAVP----WGPLCAA 529

  Fly   576 LACCHSLALLDDGLVGDPLEKATLAAVDWTL----------TKMDS--VIPKRPQ-----FKPLK 623
            :|.||||.|||..:.||||:........|.:          :..||  ||...|.     ...:.
  Rat   530 MASCHSLILLDGTIQGDPLDLKMFEGTGWNMEDGQVASCKYSTADSGTVIKPGPNASQSPVDSIT 594

  Fly   624 IIQRYHFSSALKRMSVLAGHLIPYSNEVKHIGAVKGAPEVIQKML--REVPADYEKVYLEYARRG 686
            |::::.|||.|:||||:|    ..:.:::....:|||||::.:..  ..||.::.:....|..:|
  Rat   595 ILRQFPFSSGLQRMSVIA----QLAGDLRLHVYMKGAPEMVARFCSSETVPKNFPQELRNYTVQG 655

  Fly   687 ARVLALGIKDLGTLGAQRVREMKREEVECDLTFAGFLIISCPMKPDSKSVIKELIQSSHKVVMIT 751
            .||:||..|.|.......|..:.||:||.:|.|.|.||:...:|.:::.|::||.::..:.||:|
  Rat   656 FRVIALAHKTLKMEKVSDVERLAREKVESELAFLGLLIMENRLKNETRPVLQELSEARIRTVMVT 720

  Fly   752 GDSPLTACHVAR--ELRFTRKKLIILTPPEE----DRKNNWSWVSIDGDQSYELDTKPGS-KKLS 809
            ||:..||..||:  |:.....::||:...|.    .....|..|   |.|      :||| ||:|
  Rat   721 GDNLQTAITVAKNSEMIPVGSQVIIVEANEPGDLVPASVTWQLV---GTQ------EPGSEKKVS 776

  Fly   810 -------------HLLATHDLCI--------TGEGLQYLQQNQP-----QYMRQLLPQI----TV 844
                         |.....|..|        .|:|..:....:.     .:...:||||    ||
  Rat   777 QGSQQCFRSPCRNHAFRFQDTYIDIGNSSVPCGKGYHFAMSGKSYQVLFHHFYSMLPQILVNGTV 841

  Fly   845 CARFAPKQKELVITQLKQLGYCTLMCGDGTNDVGALKHANVGVSLLTSAPVKRKRTEEEQQQAAA 909
            .||.:|.||..::.:.::|.|...|||||.||.||||.|:.|:||          :|:|
  Rat   842 FARMSPGQKSSLVEEFQKLNYYVGMCGDGANDCGALKMAHAGISL----------SEQE------ 890

  Fly   910 NAAAIAAQAQANANQQLTTRERALRRRQEHLNQTQARLQNALRDMEEQTMVKLGDASIAAPFTSK 974
                                                                   ||:|:|||||
  Rat   891 -------------------------------------------------------ASVASPFTSK 900

  Fly   975 SSSIMCVNHIIKQGRCTLVTTLQMFKILALNALIQAYCQSVLYIDGIKFSDTQATMQGIFI---A 1036
            .::|.||.|:|::||..||::..:||.|.:..:||....|:||.....|.:.|..:|.:.|   .
  Rat   901 VANIECVPHLIREGRAALVSSFGVFKYLTMYGIIQFIGTSLLYWQLQLFGNYQYLLQDVAITLMV 965

  Fly  1037 ACFLFITRAKPLKTLSKVAP------------LPNIF--NFYTISTILSQF----------AVHF 1077
            :..:.|..|.|     |:||            |.::|  :.:|...::..|          .|:.
  Rat   966 SLTMSINHAYP-----KLAPYRPAGQLLSPQLLLSVFMNSCFTCIVLVCTFLSVKQQPWYCEVYK 1025

  Fly  1078 GTLYYLTSQANILAPPREGKVKLYIDMDAEEKTKYDPNIVSSTVYIICLSLQVATI--AVNY--- 1137
            .:..:|.:|:|...           :|..|.....:..:|.::|    ||.:..|:  .|.:
  Rat  1026 YSECFLVNQSNFST-----------NMGLERNWTGNATLVPASV----LSFEGTTLWPIVTFNCI 1075

  Fly  1138 -------KGYPFMESLRSNRMLMYAIGASAALVILLSTGLAPELTEFFEIIDFPTDFRKTLLGVL 1195
                   ||.||.:.:.:|.:....:.::..|.:.:......::....|.|...|.:|.::|
  Rat  1076 SAAFIFSKGKPFRKPIYTNYLFSLLLTSAVGLTVFILFSDFQDIYRRMEFIPTTTSWRISIL--- 1137

  Fly  1196 VLDIVGAFLLDRICSFLFGE 1215
                |.||:  :.|...|.|
  Rat  1138 ----VAAFV--QFCVAFFVE 1151

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6230	NP_609490.1	P-ATPase-V	109..1193	CDD:273738	321/1231 (26%)
		E1-E2_ATPase	310..515	CDD:278548	66/210 (31%)
		Cation_ATPase	<590..664	CDD:289987	25/90 (28%)
		COG4087	<850..901	CDD:226572	20/50 (40%)
Atp13a5	XP_038944228.1	P5-ATPase	23..142	CDD:403569	21/104 (20%)
Atp13a5	XP_038944228.1	P-type_ATPase_cation	174..1020	CDD:319842	268/956 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54176
OrthoDB	1	1.010	-	-		D172453at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.930