Protein Alignment CG6230 and Atp13a4

DIOPT Version :10

• Sequence 1: NP_609490.1
• Gene: CG6230 / 34546
• FlyBaseID: FBgn0027582
• Length: 1225
• Species: Drosophila melanogaster
• Sequence 2: NP_001178587.2
• Gene: Atp13a4 / 288026
• RGDID: 1306927
• Length: 1193
• Species: Rattus norvegicus
• Alignment Length: 1245
• Identity: 333/1245 - (26%)
• Similarity: 545/1245 - (43%)
• Gaps: 257/1245 - (20%)

  Fly    58 VLPFVPLYLSAFYLWINVTGGQENDTTNNDVITADNQTTTD--NITTWNDVGFIGVLAIAFLHIL 120
            :||.|..:..|:.:|.|.......:.   |::..   .|||  .|.:|..|.:|.:.|::....|
  Rat    46 MLPLVFYWRPAWRVWANCVPCSLQEA---DIVLL---RTTDEFKIYSWKKVMWISLSALSSTSGL 104

  Fly   121 TLLFCYWSVHVL----AFLTCRRVKLPGANVLAKVVPTPNNGNSKIVPIRSSKLEDGSTQYYFVF 181
            |      ..|.|    .|:..|.::.|...|                             .|...
  Rat   105 T------PDHPLIADEEFIINRAIRKPDLKV-----------------------------RYIKV 134

  Fly   182 QKTKYVWNEDRKTFRAVEFPVNGLLSTYSSSR-------GLETEE-DIKRATQTYGNNEMEMVVP 238
            ||.:||||.....|:    .:..|....||::       ||.:|| :|:|.  ..|.|.:::.:.
  Rat   135 QKIRYVWNNLEGQFQ----KIGSLEDCLSSAKIHQKFGLGLTSEEQEIRRL--ICGPNAIDVEII 193

  Fly   239 EFHELFIERATAPFFVFQVFSVGLWCMDDYWYYSLFTLFM-LIAFECTI--VKQQLRNMSEIRKM 300
            ...:|.::....||::||:|||.||..:||..|:|..:.| :|:...|:  ::||...:..:.:.
  Rat   194 PIWKLLVKEVLNPFYIFQLFSVCLWFSEDYKEYALAIILMSVISIALTVYDLRQQSVKLHHLVES 258

  Fly   301 GNKPYLIYAFRQNKWRHLGSDELLPGDLVSITRSQNDNIVPCDLVILRGSCIVDESMLTGESVPL 365
            .|...:....|:...:.|.|..|:||||:.:|.|:..  :|||.|::.|||:|||.||||||:|:
  Rat   259 HNSITVSVYERKAGAQDLESRLLVPGDLLILTGSRVQ--MPCDAVLIDGSCVVDEGMLTGESIPV 321

  Fly   366 MKESL-ESLDNLDVEMDAEGDGKLFVLFGGTKVVQHTAPTKESLRAPDGGCIGYVIRTGFNTSQG 429
            .|..| ::..:...:|.:|.|.:..:||.||:|:|..|....::||       .|::|||||::|
  Rat   322 TKTPLSQTASSAPWKMQSEADPRRHILFCGTEVIQAKAAGSGTVRA-------VVLQTGFNTAKG 379

  Fly   430 KLLRTILFGANRATENNVETFAFIAFLMVFAVAAASY---VWVKGSEDPERNRYKLFLECTLILT 491
            .|:|:||:......:...:...|:..|:..|.....|   |:|...|.||    ::..:...::|
  Rat   380 DLVRSILYPKPMNFKLYRDAIRFLLCLVGTATIGMIYTLCVYVLSGEPPE----EVVRKALDVIT 440

  Fly   492 SIIPPDLPIELTLAVNTSLIQLTKLFVFCTEPFRIPFAGKVQICCFDKTGTLTTDNLMVEGIAGL 556
            ..:||.||..||..:..:..:|.|..:||..|.||...|::.:.|||||||||...|.:.|:...
  Rat   441 IAVPPALPAALTTGIIYAQRRLKKKGIFCISPQRINVCGQLNLVCFDKTGTLTRGGLDLWGVVPC 505

  Fly   557 APNGACVPIEKAEGNTV------QVLACCHSLALLDDGLVGDPLEKATLAAVDWTLT-------- 607
            ..||.......|.|..|      ..:|.||||.|||..:.||||:.....|..|.:|
  Rat   506 DQNGFQAVHSFASGEAVPWGPLCAAMATCHSLILLDGTIQGDPLDLKMFEATQWEMTVSGDDFHN 570

  Fly   608 ---KMDSVIPKRPQ------FKPLKIIQRYHFSSALKRMSVLAGHLIPYSNEVKHIGA-----VK 658
               ...:::.|.|.      .:.|.|:.::.|||||:||:|:          |:..|.     :|
  Rat   571 KEMLAHTMVVKPPDTVGQVPAEGLAILHQFPFSSALQRMTVI----------VQETGGGRMAFMK 625

  Fly   659 GAPEVIQKMLR--EVPADYEKVYLEYARRGARVLALGIKDLGTLGAQRVREMKREEVECDLTFAG 721
            ||||.:....:  .||..:......|..:|.||:||..|.|.|  ......:.||:||.||.|.|
  Rat   626 GAPERVASFCQPDTVPTTFISELQVYTTQGFRVIALAYKKLET--DCPTTTLMREKVESDLIFLG 688

  Fly   722 FLIISCPMKPDSKSVIKELIQSSHKVVMITGDSPLTACHVARELRFTR--KKLIILTPPEEDRKN 784
            .||:...:|.:::.|::|||.:..:..|||||:..||..|||:.....  :|:|::...|....:
  Rat   689 LLILENRLKEETRPVLEELISARIRTAMITGDNLQTAITVARKSGMVSEGQKVILVEANEATDSS 753

  Fly   785 NWS--WVSID-------GDQSYELDTK---PGSKKLSHLLATHDLCITGEGLQYLQQNQPQYMRQ 837
            :.|  |..::       |.|...::.:   |.:.:..:    :...::|:..|.:.    |:...
  Rat   754 SASITWKLVEEKKHGLFGSQDTYINIREEVPENGREGN----YHFALSGKSFQVIS----QHFSS 810

  Fly   838 LLPQI----TVCARFAPKQKELVITQLKQLGYCTLMCGDGTNDVGALKHANVGVSLLTSAPVKRK 898
            |||:|    |:.||.:|.||..::.:.::|.|...|||||.||.||||.|:|||||
  Rat   811 LLPKILINGTIFARMSPGQKSSLVEEFQKLDYFVGMCGDGANDCGALKMAHVGVSL--------- 866

  Fly   899 RTEEEQQQAAANAAAIAAQAQANANQQLTTRERALRRRQEHLNQTQARLQNALRDMEEQTMVKLG 963
             :|:|
  Rat   867 -SEQE------------------------------------------------------------ 870

  Fly   964 DASIAAPFTSKSSSIMCVNHIIKQGRCTLVTTLQMFKILALNALIQAYCQSVLYIDGIKFSDTQA 1028
             ||:|:|||||:.:|.||.|:||:||..|||:..|||.:||.::||.....:||......|:.|.
  Rat   871 -ASVASPFTSKTPNIECVPHLIKEGRAALVTSFCMFKYMALYSMIQYVGVLLLYWKTNSLSNYQF 934

  Fly  1029 TMQGIFIAACFLFIT--------RAKPLKTLSKVAPLPNIFNFYTISTILSQFAVHFGTLYYLTS 1085
            ..|.:.|.. .:.:|        :..|.:...::...|.:.:  .|..||...|:|......:..
  Rat   935 LFQDLAITT-LIGVTMNLNGANPKLVPFRPAGRLISPPLLLS--VILNILLSLAMHIVGFILVQK 996

  Fly  1086 QA------NILAPPREGKVK-LYIDMDAEEKTKYDPNIVS---STVYIICLSLQVATIAVNYKGY 1140
            |.      :.:.|.|...|. |....:..|||:.:....|   :|::.:.....:....|..||.
  Rat   997 QPWYSMDYHSVCPVRNESVSALSASPNVPEKTRSNSTFASFENTTIWFLGTINCIVVALVFSKGK 1061

  Fly  1141 PFMESLRSNRMLMYAIGASAALVILLSTGLA--------PELTEFFEIIDFPTDFRKTLLGVLVL 1197
            ||.:...:|.:.:        ||::|..|:.        |||....:::..|..:|..:|.::..
  Rat  1062 PFRQPTYTNYIFV--------LVLILQMGVCLFILFADIPELHRRLDLLCTPVLWRVYILIMVSS 1118

  Fly  1198 DIVGAFLLDR 1207
            :.|.:..:::
  Rat  1119 NFVVSLAVEK 1128

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6230	NP_609490.1	P-type_ATPase_cation	220..1152	CDD:319843	284/1004 (28%)
Atp13a4	NP_001178587.2	P5-ATPase	17..142	CDD:463565	28/136 (21%)
		P-type_ATPase_cation	174..1000	CDD:319842	271/934 (29%)