Protein Alignment CG6230 and Atp13a4

DIOPT Version :9

• Sequence 1: NP_609490.1
• Gene: CG6230 / 34546
• FlyBaseID: FBgn0027582
• Length: 1225
• Species: Drosophila melanogaster
• Sequence 2: NP_001158084.1
• Gene: Atp13a4 / 224079
• MGIID: 1924456
• Length: 1193
• Species: Mus musculus
• Alignment Length: 1257
• Identity: 333/1257 - (26%)
• Similarity: 546/1257 - (43%)
• Gaps: 281/1257 - (22%)

  Fly    58 VLPFVPLYLSAFYLWINVTGGQENDTTNNDVITADNQTTTD--NITTWNDVGFIGVLAIAFLHIL 120
            :||.|..:..|:.:|.|.......:.   ||:..   .|||  .|.:|..|.:|.:.|::....|
Mouse    46 MLPLVFYWRPAWRVWANCVPCSLQEA---DVVLL---KTTDEFKIYSWKKVIWISLSALSSTSGL 104

  Fly   121 TLLFCYWSVHVL----AFLTCRRVKLPGANVLAKVVPTPNNGNSKIVPIRSSKLEDGSTQYYFVF 181
            |      ..|.|    .::..|.::.|...|                             .|...
Mouse   105 T------PDHPLITDEGYIINRAIRKPDLKV-----------------------------RYIKV 134

  Fly   182 QKTKYVWNEDRKTFRAVEFPVNGLLSTYSSSR--------GLETEE-DIKRATQTYGNNEMEMVV 237
            ||.:||||.....|:.:     |.|..:.||.        ||.:|| :|:|.  ..|.|.:::.:
Mouse   135 QKIRYVWNNLEGQFQKI-----GSLEDWLSSAKIHQKFGLGLTSEEQEIRRL--ICGPNAIDVEI 192

  Fly   238 PEFHELFIERATAPFFVFQVFSVGLWCMDDYWYYSLFTLFM-LIAFECTI--VKQQLRNMSEIRK 299
            ....:|.|:....||::||:|||.||..:||..|:|..:.| :|:...|:  ::||...:..:.:
Mouse   193 TPIWKLLIKEVLNPFYIFQLFSVCLWFSEDYKEYALAIILMSVISIALTVYDLRQQSVKLHHLVE 257

  Fly   300 MGNKPYLIYAFRQNKWRHLGSDELLPGDLVSITRSQNDNIVPCDLVILRGSCIVDESMLTGESVP 364
            ..|...:....|:...:.|.|..|:||||:.:|.|:..  :|||.:::.|||:|||.||||||:|
Mouse   258 SHNSITVSVYERKAGAQDLESRLLVPGDLLILTGSRVQ--MPCDAILIDGSCVVDEGMLTGESIP 320

  Fly   365 LMKESL-ESLDNLDVEMDAEGDGKLFVLFGGTKVVQHTAPTKESLRAPDGGCIGYVIRTGFNTSQ 428
            :.|..| ::..::..:|.:|.|.:..|||.||:|:|..|....::||       .|::|||||::
Mouse   321 VTKTPLSQTASSVPWKMQSEADPRRHVLFCGTEVIQAKAAGSGAVRA-------VVLQTGFNTAK 378

  Fly   429 GKLLRTILFGANRATENNVETFAFIAFLMVFAVAAASY---VWVKGSEDPERNRYKLFLECTLIL 490
            |.|:|:||:......:...:...|:..|:..|.....|   |:|...|.||    ::..:...::
Mouse   379 GDLVRSILYPKPMNFKLYRDAIRFLLCLVGTATIGMVYTLCVYVLSGEPPE----EVVRKALDVI 439

  Fly   491 TSIIPPDLPIELTLAVNTSLIQLTKLFVFCTEPFRIPFAGKVQICCFDKTGTLTTDNLMVEGIAG 555
            |..:||.||..||..:..:..:|.|..:||..|.||...|::.:.|||||||||...|...|:..
Mouse   440 TIAVPPALPAALTTGIIYAQRRLKKKGIFCISPQRINVCGQLNLVCFDKTGTLTRGGLDPWGVVP 504

  Fly   556 LAPNGACVPIEKAEGNTV------QVLACCHSLALLDDGLVGDPLEKATLAAVDWTLT------- 607
            ...||.......|.|..:      ..:|.||||.|||..:.||||:.....|..|.:|
Mouse   505 CDQNGFQAVHSFASGKALPQGPLCAAMASCHSLILLDGTIQGDPLDLKMFEATKWEMTASGDDFH 569

  Fly   608 -----------KMDSVIPKRPQFKPLKIIQRYHFSSALKRMSVLAGHLIPYSNEVKHIGA----- 656
                       |...::.:.|. :.|.|:.::.|||||:||:|:          |:.:|.
Mouse   570 IKEMLAHTIVVKPTDMVAQVPA-EGLAIVHQFPFSSALQRMTVI----------VQEMGGGRLAF 623

  Fly   657 VKGAPEVIQKMLR--EVPADYEKVYLEYARRGARVLALGIKDLGTLGAQRVREM-------KREE 712
            :|||||.:....:  .||..:......|..:|.||:||..|.|         ||       .||:
Mouse   624 MKGAPERVASFCQPDTVPTSFISELQIYTTQGFRVIALAYKKL---------EMDCPTTALMREK 679

  Fly   713 VECDLTFAGFLIISCPMKPDSKSVIKELIQSSHKVVMITGDSPLTACHVARELRFTR--KKLIIL 775
            ||.||.|.|.||:...:|.::|.|::|||.:..:.||||||:..||..|||:.....  :|:|::
Mouse   680 VESDLVFLGLLILENRLKEETKPVLEELISARIRTVMITGDNLQTAITVARKSGMVSEGQKVILV 744

  Fly   776 TPPEEDRKN--NWSWVSIDGDQSYELDTKPG--SKKLSHLL-----------ATHDLCITGEGLQ 825
            ...|....:  :.||..::       :.|||  ..:.:::.           .::...::|:...
Mouse   745 EANEATGSSSASISWKLVE-------EKKPGPFGSQDTYINIREEVPENGRDGSYHFALSGKSFH 802

  Fly   826 YLQQNQPQYMRQLLPQI----TVCARFAPKQKELVITQLKQLGYCTLMCGDGTNDVGALKHANVG 886
            .:.    ||...|||:|    |:.||.:|.||..::.:.::|.|...|||||.||.||||.|:||
Mouse   803 VIS----QYFSSLLPKILINGTIFARMSPGQKSSLVEEFQKLDYFVGMCGDGANDCGALKMAHVG 863

  Fly   887 VSLLTSAPVKRKRTEEEQQQAAANAAAIAAQAQANANQQLTTRERALRRRQEHLNQTQARLQNAL 951
            :||          :|:|
Mouse   864 ISL----------SEQE------------------------------------------------ 870

  Fly   952 RDMEEQTMVKLGDASIAAPFTSKSSSIMCVNHIIKQGRCTLVTTLQMFKILALNALIQAYCQSVL 1016
                         ||:|:|||||:.:|.||.|:||:||..|||:..|||.:||.::||.....:|
Mouse   871 -------------ASVASPFTSKTPNIECVPHLIKEGRAALVTSFCMFKYMALYSMIQYVGVLLL 922

  Fly  1017 YIDGIKFSDTQATMQGIFIAACFLFIT--------RAKPLKTLSKVAPLPNIFNFYTISTILSQF 1073
            |......|:.|...|.:.|.. .:.:|        :..|.:...::...|.:.:  .:..||...
Mouse   923 YWKTNSLSNYQFLFQDLAITT-LIGVTMNLNGANPKLVPFRPAGRLISPPLLLS--VVLNILLSL 984

  Fly  1074 AVHF-GTL------YYLTSQANILAPPREGKVKLYIDMDAEEKTKYDPNIVS---STVYIICLSL 1128
            |:|. |.:      :|:....::.....|....|.......|||:.:....|   :|::.:....
Mouse   985 AMHIVGFILVQKQPWYIMDYHSVCPVRNESASALAASPSVPEKTRSNSTFASFENTTIWFLGTIN 1049

  Fly  1129 QVATIAVNYKGYPFMESLRSNRMLMYAIGASAALVILLSTGLA--------PELTEFFEIIDFPT 1185
            .:....|..||.||.:...:|.:.:        ||::|..|:.        ||:....:::..|.
Mouse  1050 CIFVALVFSKGKPFRQPTYTNYIFV--------LVLILQMGVCLFILFADIPEMHRRLDLLCTPV 1106

  Fly  1186 DFRKTLLGVLVLDIVGAFLLDR 1207
            .:|..:|.::..:.|.:..:::
Mouse  1107 LWRVYILIMISSNFVVSLAVEK 1128

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6230	NP_609490.1	P-ATPase-V	109..1193	CDD:273738	317/1188 (27%)
		E1-E2_ATPase	310..515	CDD:278548	69/208 (33%)
		Cation_ATPase	<590..664	CDD:289987	26/96 (27%)
		COG4087	<850..901	CDD:226572	21/50 (42%)
Atp13a4	NP_001158084.1	P-ATPase-V	18..1115	CDD:273738	332/1242 (27%)
		P5-ATPase	18..137	CDD:289194	25/131 (19%)
		Cation_ATPase_N	<170..218	CDD:279080	17/49 (35%)
		E1-E2_ATPase	228..472	CDD:278548	79/256 (31%)
		Cation_ATPase	<596..635	CDD:289987	16/48 (33%)
		COG4087	<821..>870	CDD:226572	24/58 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54176
OrthoDB	1	1.010	-	-		D172453at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.930