DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6230 and atp13a3

DIOPT Version :9

Sequence 1:	NP_609490.1	Gene:	CG6230 / 34546	FlyBaseID:	FBgn0027582	Length:	1225	Species:	Drosophila melanogaster
Sequence 2:	XP_031757979.1	Gene:	atp13a3 / 100497750	XenbaseID:	XB-GENE-6045268	Length:	1247	Species:	Xenopus tropicalis

Alignment Length:	1304	Identity:	355/1304 - (27%)
Similarity:	583/1304 - (44%)	Gaps:	297/1304 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 GQENDTTNNDVITADNQTTTDNITTWNDVGFIGVLAIAFLHIL-----TLLFCYWSVHVLAFLTC 137
            |::.:....|.:..|..    |:..|.       ||:..:.:|     .||..||........||
Frog     4 GEKINKGEEDEMEIDGY----NLCRWK-------LALVAIGVLCSGGFLLLLLYWMPKWRVKATC 57

  Fly   138 RRVKLPGANVL-------------AKV----------VPTPNNGNSKIVPIRSSKLEDGSTQY-- 177
            .||.|...:|:             |||          ...|.:...|:.......|.:..|::
Frog    58 TRVTLKDCDVVLLRTTDEFRQWFCAKVRILLSPVTHPFQIPESVAGKVTNGHIGHLPESHTEHHE 122

  Fly   178 ---------------YFVFQKTKYVWNEDRKTFRAVEFPVNGLLST---YSSSRGLETE-EDIKR 223
                           |||.....|.||:..:||...:....|:..:   ...|:||..| .|.::
Frog   123 DHPMNNATVPLHEVRYFVHHSLTYYWNDVHQTFSLFKGLDEGIQCSAMHREHSQGLCKEIHDYRK 187

  Fly   224 ATQTYGNNEMEMVVPEFHELFIERATAPFFVFQVFSVGLWCMDDYWYYS----LFTLFMLIAFEC 284
            .  .||.||:.:.||...:|.::....||::||:|||.|||.|:|:||:    |.::..:|:...
Frog   188 L--FYGINEITVKVPSLFKLLVKEVLNPFYIFQLFSVILWCTDEYYYYASAILLMSVISIISSLY 250

  Fly   285 TIVKQ--QLRNM----SEIRKMGNKPYLIYAFRQNK-WRHLGSDELLPGDLVSITRSQNDNIVPC 342
            ||.||  .|.:|    |.:|        :..:|..| ...:.|.:|:|||::.|  ..|..|:||
Frog   251 TIKKQYIMLHDMVSAHSIVR--------VSVYRGKKEAEEILSTDLVPGDIMLI--PPNGTIMPC 305

  Fly   343 DLVILRGSCIVDESMLTGESVPLMKESLESLDNLDVEMDAEGD---------GKLFVLFGGTKVV 398
            |.|::.|:|||:||||||||||:.|.:|.     |...|:...         .|...||.||.|:
Frog   306 DAVLISGTCIVNESMLTGESVPVTKTNLP-----DPTTDSRAPENEIYSTEIHKRHTLFCGTNVI 365

  Fly   399 QHTAPTKESLRAPDGGCIGYVIRTGFNTSQGKLLRTILFGANRATENNVETFAFIAFLMVFAVAA 463
            |......||::|       .::||||:||:|:|:|.||:  .:.|:..:...|::..|.:.|||.
Frog   366 QTRFYAGESVKA-------IIVRTGFSTSKGQLIRAILY--PKPTDFKLYRDAYLFLLCLVAVAG 421

  Fly   464 ASYVWV----------KGSEDPERNRYKLFLECTLILTSIIPPDLPIELTLAVNTSLIQLTKLFV 518
            ..:::.          .|.         :.:|...|:|..:||.||..:|..:..:..:|..|.:
Frog   422 IGFLYTIINSILNKVPAGI---------IIIESLDIITITVPPALPAAMTAGIVYAQKRLKNLGI 477

  Fly   519 FCTEPFRIPFAGKVQICCFDKTGTLTTDNLMVEGIAGLAPNGACVPIEKAEGNTV---QVLAC-- 578
            ||..|.||...|::.:.|||||||||.|.|.:.||..:......:|.|||...::   |.:||
Frog   478 FCISPQRINICGQLNLICFDKTGTLTEDGLDLWGIQRVEDARFLLPEEKACSESLVKSQFVACMA 542

  Fly   579 -CHSLALLDDGLVGDPLEKATLAAVDWTLTK------------MDSVI--PKRP--QFKP----- 621
             ||||..:|..|.||||:.....|:.|.|.:            |.:|:  ||:|  ..||
Frog   543 TCHSLTKIDGVLSGDPLDLKMFEAIGWILEEATEEETALHNKMMPTVVQPPKQPVTDQKPAASQE 607

  Fly   622 -----------LKIIQRYHFSSALKRMSVLAGHLIPYSNEVKHIGAVKGAPEVIQKMLRE--VPA 673
                       :.|::::.|||||:||:|:|..|    .|.|....||||||||..:.::  ||.
Frog   608 MELFEIPTTYEIGIVRQFPFSSALQRMAVVARIL----GEKKMDAYVKGAPEVIASLCKQETVPH 668

  Fly   674 DYEKVYLEYARRGARVLALGIKDL-GTLGAQRVREMKREEVECDLTFAGFLIISCPMKPDSKSVI 737
            |:..|..||.::|.||:||..:.| ..:...:|:.:.|:.:|.::||.|.:|:...:|.::.||:
Frog   669 DFASVLEEYTKQGYRVIALAHRKLESKISWHKVQNISRDAIESNMTFLGLIIMQNKLKEETPSVL 733

  Fly   738 KELIQSSHKVVMITGDSPLTACHVARE--LRFTRKKLII--LTPPEEDRKNNWSW--------VS 790
            ::|..::.:.||:|||:.|||..|||:  :...::|:|:  ..||::.|....||        .|
Frog   734 EDLRNANIRTVMVTGDNMLTAISVARDCGMILPQEKVIVAEALPPKDGRVATISWHYADSLPRSS 798

  Fly   791 IDGDQSYELDTKPGSKKL-SHLLATHDLCITGEGLQYLQQNQPQYMRQLLPQITVCARFAPKQKE 854
            ::...|.::..|..|..| .:.:|.:...:.|:....:.::.|..:.:|:...||.||.||.||.
Frog   799 LNTIDSEDIPVKVVSDSLEDNYVANYHFAMNGKSFGVILEHFPDLVPKLVLHGTVFARMAPDQKT 863

  Fly   855 LVITQLKQLGYCTLMCGDGTNDVGALKHANVGVSLLTSAPVKRKRTEEEQQQAAANAAAIAAQAQ 919
            .::.:|:.:.|...|||||.||.||||.|:.|:||
Frog   864 QLVEELQNVDYYVGMCGDGANDCGALKRAHGGISL------------------------------ 898

  Fly   920 ANANQQLTTRERALRRRQEHLNQTQARLQNALRDMEEQTMVKLGDASIAAPFTSKSSSIMCVNHI 984
                .:|                                     :||:|:||||::.||.||.::
Frog   899 ----SEL-------------------------------------EASVASPFTSRTPSISCVPNL 922

  Fly   985 IKQGRCTLVTTLQMFKILALNALIQAYCQSVLYIDGIKFSDTQATMQGIFIAACFLFITRAKPL- 1048
            |::||..|:|:..:||.:||.:|||.:..::||.......|.|.....:.|....:|.....|.
Frog   923 IREGRAALITSFCVFKFMALYSLIQYFSVTLLYSILSNLGDFQFLFIDLAIILIVVFTMSLNPAW 987

  Fly  1049 KTLSKVAPLPNIFNFYTISTILSQFAVHFG--TLYYL--------------TSQANILAPPREGK 1097
            |.|....|...:.:...:.::|||..:..|  |..:|              ::..|:.|
Frog   988 KVLVAQRPPSGLISGPLLFSVLSQILICLGFQTWAFLWVKEQPWYEVWIPNSNVCNVSA------ 1046

  Fly  1098 VKLYIDMDAEEKTKYDPNIVSSTVYIICLSLQVATIAVNY-KGYPFMESLRSNRMLMYAIGASAA 1161
             .|:.|...:|..  ..|..::|::.:. |.|...:|:.: ||.||.:.  |.:...:.:.....
Frog  1047 -DLHYDNHTDEHN--IKNYENTTLFYVS-SFQYLIVAIVFSKGKPFRQP--SYKNWFFVVSVLGL 1105

  Fly  1162 LVILLSTGLAP--ELTEFFEIIDFPTDFRKTLLGVLVLD-----IVGAFLLDRICSFLF------ 1213
            .:::|...|.|  .:.:|||::..|.::|..:|.::|::     :|..|:||.:...|.
Frog  1106 YILILFFMLYPITPVDDFFELVCVPFEWRIKMLIIIVINAAVSILVENFVLDMLLGKLVFSRDKQ 1170

  Fly  1214 GETR 1217
            |||:
Frog  1171 GETQ 1174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6230	NP_609490.1	P-ATPase-V	109..1193	CDD:273738	340/1236 (28%)
		E1-E2_ATPase	310..515	CDD:278548	69/224 (31%)
		Cation_ATPase	<590..664	CDD:289987	33/105 (31%)
		COG4087	<850..901	CDD:226572	20/50 (40%)
atp13a3	XP_031757979.1	P-ATPase-V	12..1140	CDD:273738	345/1260 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172453at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010