Protein Alignment CG6230 and atp13a5l.3

DIOPT Version :10

• Sequence 1: NP_609490.1
• Gene: CG6230 / 34546
• FlyBaseID: FBgn0027582
• Length: 1225
• Species: Drosophila melanogaster
• Sequence 2: XP_002934093.3
• Gene: atp13a5l.3 / 100497259
• XenbaseID: XB-GENE-22167926
• Length: 1189
• Species: Xenopus tropicalis
• Alignment Length: 1240
• Identity: 334/1240 - (26%)
• Similarity: 537/1240 - (43%)
• Gaps: 251/1240 - (20%)

  Fly   104 NDVGFIGVLAIAFLHILTLL--FC---------YWSVHVLAFLTCRRVKLPGANV---------- 147
            |::...|...:.:...|:::  ||         ||...|..:..|....|..|||
 Frog    14 NEMELFGYKTVRWRQALSIIGYFCSLGFLRILFYWKPEVDVWCQCTPCTLEEANVVLLRTTDELR 78

  Fly   148 ------LAKVVP-----TPN-----NGNSKIVPIRSSKLEDGSTQYYFV-FQKTKYVWNEDRKTF 195
                  |.::.|     .|:     |.||    |.|..|.....::..| .||.:||||...:.|
 Frog    79 QYSKKKLIEIYPHIPGGKPDHHILTNKNS----ILSKSLIKSEGKFRCVKVQKIRYVWNTTERRF 139

  Fly   196 RAVEFPVNGLLSTYSSSRGLET---------EEDIKRATQTYGNNEMEMVVPEFHELFIERATAP 251
            :.     .|:|....|...:.|         |::|::  |..|.|.:::.:.....|..:....|
 Frog   140 QR-----TGILEEELSCLDIHTQFGSGLTPEEQEIRK--QVCGLNTIDVEIKPIWVLLFKEIFNP 197

  Fly   252 FFVFQVFSVGLWCMDDYWYYSLFTLFM-LIAFECTIVKQQLRNMSEIRKM--GNKPYLIYAFRQN 313
            |::||.:::.:|....|..||...|.| :::...|:...::::: ::.||  .:...::.|.|:|
 Frog   198 FYIFQAYTLCMWISCGYLEYSFVILAMTILSIIATVYNLRVQSV-KLHKMAKSSSSIMVKALRRN 261

  Fly   314 -KWRHLGSDELLPGDLVSITRSQNDNIVPCDLVILRGSCIVDESMLTGESVPLMKESLESLD-NL 376
             :...:.|..|:|||::::  :.|...:|||.:::.|.|.|:|..|||||:|:.|..|...: .:
 Frog   262 GELEEVKSKCLVPGDVINL--AGNKLFLPCDAILINGGCTVNEGALTGESIPVTKIPLPHTEGTV 324

  Fly   377 DVEMDAEGDGKLFVLFGGTKVVQHTAPTKESLRAPDGGCIGYVIRTGFNTSQGKLLRTILFGANR 441
            ..::....|.|..|||.||:|:|..|...:.::|       .|::|||||::|.|:|.||:....
 Frog   325 PWKLQCGEDYKRHVLFCGTEVIQTKAHGPDLVKA-------VVLQTGFNTAKGDLVRAILYNKPV 382

  Fly   442 ATENNVETFAFIAFLMVFAVAAASYVWV----KGSEDPERNRYKLFLECTLILTSIIPPDLPIEL 502
            ..:.:.|...|:..|:..::....|..|    .|:     ..:...|...|:||..:.|.||..|
 Frog   383 NVKLHREAIRFLLVLVGISLCGVIYTAVIYTLNGA-----TIHNTVLMSFLMLTLAVNPALPASL 442

  Fly   503 TLAVNTSLIQLTKLFVFCTEPFRIPFAGKVQICCFDKTGTLTTDNLMVEGIA----------GLA 557
            ||.:..:..:|.||.:||..|.||..||::.:.|||||||||.|.|.:.|||          .|.
 Frog   443 TLGLLYAQTRLKKLGIFCISPQRINIAGQLNLVCFDKTGTLTEDALDLHGIAPSDGGSFQDIHLF 507

  Fly   558 PNGACVPIEKAEGNTVQVLACCHSLALLDDGLVGDPLEKATLAAVDW------------------ 604
            .:|..:|    .|..:..:|.||||.:||..:.||||:........|
 Frog   508 TSGETLP----WGPVLGAMASCHSLIMLDGEIQGDPLDIKMFEGTGWKLENHPADGTKGGETISC 568

  Fly   605 TLTKMDSVIPKRPQFKPLKIIQRYHFSSALKRMSVLAGHLIPYSNEVKHIGAVKGAPEVIQKMLR 669
            ||.|......|.| .:.:.|:.::.|||:|:||||:|    ..:.|......:|||||::.|..:
 Frog   569 TLVKPGPRAGKVP-VEGITILHQFPFSSSLQRMSVIA----QITGETDLTVFMKGAPEMVVKFCK 628

  Fly   670 --EVPADYEKVYLEYARRGARVLALGIKDLGTLGAQRVREMKREEVECDLTFAGFLIISCPMKPD 732
              .||.:..|....|..:|.||:||....|...|...::.|:||.||.||.|.|.||:...:||:
 Frog   629 PDTVPQNISKKLDFYTAQGFRVIALAHGFLQKEGLLAIQHMEREFVEADLIFIGLLIMENRLKPE 693

  Fly   733 SKSVIKELIQSSHKVVMITGDSPLTACHVARELRFTRK--KLIIL--TPPEEDRKNNWSWVSIDG 793
            :.:|:.||.::..:.||||||:..||.::.:......|  |:|::  |.|::|...:.:|.::..
 Frog   694 TNAVLHELTEARIRNVMITGDNLQTALNIGKNCGMVSKTSKVIVIEATEPQKDVPASITWKTLTE 758

  Fly   794 DQSYELDTKP---GSK---KLSHLL--ATHDLCITGEGLQYLQQNQPQYMRQLLPQI----TVCA 846
            :|.....|..   |||   ..|.|:  |.| ..:.|:..|.:.    |:...|:|:|    |:.|
 Frog   759 NQENGHQTNDSYFGSKDRWNSSTLVPGAFH-FVMNGKSFQIIM----QHFYDLVPKILLNGTIFA 818

  Fly   847 RFAPKQKELVITQLKQLGYCTLMCGDGTNDVGALKHANVGVSLLTSAPVKRKRTEEEQQQAAANA 911
            |..|.||..:|.:.::|.|...|||||.||.||||.||||:||
 Frog   819 RMTPLQKSSLIEEFQKLDYYVGMCGDGANDCGALKMANVGISL---------------------- 861

  Fly   912 AAIAAQAQANANQQLTTRERALRRRQEHLNQTQARLQNALRDMEEQTMVKLGDASIAAPFTSKSS 976
                        .||                                     :||:|:|||||..
 Frog   862 ------------SQL-------------------------------------EASVASPFTSKIP 877

  Fly   977 SIMCVNHIIKQGRCTLVTTLQMFKILALNALIQAYCQSVLYIDGIKFSDTQATMQGIFIAACFLF 1041
            :|.||..:||:||..|||:..|||.:.|..:|.......|:......|..|..||.|.|...|..
 Frog   878 NIECVPLLIKEGRNALVTSFSMFKFMTLLTMIVLTSVVFLFWRQTLLSSAQYLMQSIAIITSFSL 942

  Fly  1042 ITRAKPLKTLSKVAPLPNIFNFYTISTILSQ---FAVHFGTLYYLTSQAN----ILAPPREGKVK 1099
                    |.|...|.|.:..|.....:||.   .:|...:|:.:..|..    :...|...:..
 Frog   943 --------TSSLNGPAPKLAPFRPPGQLLSPPLLLSVFLHSLFTIALQTTAFVLLQQQPWYNEHD 999

  Fly  1100 LY-----IDMDAEEKT----KYDPNIVSSTVYIICLSLQVATIAVNYKGYPFMESLRSNRMLMYA 1155
            ::     ::..:|..|    ::..|.:::|.:|:.....:|...|..||.||.:.|.:|.:|...
 Frog  1000 VFSACSPLNHSSENGTTRLPRFSENYLATTEWIVTGMNFIAIEFVFSKGRPFRQRLYTNYLLSIM 1064

  Fly  1156 IGASAALVILLSTGLAPELTEFFEIIDFPTDFR-KTLLGVLVLDIVGAF-------------LLD 1206
            |....|:.:.........:...||::..|.::| ..|:.|||..||..|             ||.
 Frog  1065 ITLQVAVYLFFLFADIESIYTAFEMVCTPFNWRVYILIMVLVHFIVSYFVEEGFIENRTLWLLLK 1129

  Fly  1207 RICSF 1211
            ::|.:
 Frog  1130 KLCKY 1134

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6230	NP_609490.1	P-type_ATPase_cation	220..1152	CDD:319843	282/1002 (28%)
atp13a5l.3	XP_002934093.3	P5-ATPase	12..133	CDD:463565	27/122 (22%)
		Haloacid Dehalogenase-like Hydrolases	165..995	CDD:473868	270/939 (29%)