Protein Alignment CG6230 and atp13a5

DIOPT Version :10

• Sequence 1: NP_609490.1
• Gene: CG6230 / 34546
• FlyBaseID: FBgn0027582
• Length: 1225
• Species: Drosophila melanogaster
• Sequence 2: XP_012818836.2
• Gene: atp13a5 / 100485018
• XenbaseID: XB-GENE-12441880
• Length: 1197
• Species: Xenopus tropicalis
• Alignment Length: 1222
• Identity: 331/1222 - (27%)
• Similarity: 536/1222 - (43%)
• Gaps: 255/1222 - (20%)

  Fly   119 ILTLLFCYWSVHVLAFLTCRRVKLPGANVL-------------AKVVPTPNNGNSKIVPIRSSKL 170
            :|.||| ||......:..|....|..|||.             ..::.|..:....::...|.||
 Frog    46 LLWLLF-YWKPEWEVWAYCEPCLLENANVFLLRSTDEFKHCSKKNLLWTHLSKQDSVLLQTSDKL 109

  Fly   171 EDGSTQY---------------YFVFQKTKYVWNEDRKTFRAVEFPVNGLLSTYSSSR------- 213
            .. ..:|               |...||.||||....|.|:    ....|...||.|:
 Frog   110 ST-KDEYSIINKAIMMPEHKVRYIRVQKIKYVWLLSEKKFQ----KAGALEDLYSCSQIHSRFGS 169

  Fly   214 GLETEEDIKRATQTYGNNEMEMVVPEFHELFIERATAPFFVFQVFSVGLWCMDDYWYYSLFTLFM 278
            ||..||...|.. ..|.|.:|:.|....:|..:....||::||:.|:.||..:.|..||:..:.:
 Frog   170 GLTQEEQTLRRL-ICGPNAIEVEVVPVWKLLFKEVLNPFYLFQIASLSLWLAEGYIEYSVVIIII 233

  Fly   279 -LIAFECTI--VKQQLRNMSEIRKMGNKPYLIYAFRQNKWRHLGSDELLPGDLVSITRSQNDNIV 340
             ||:...|:  ::||...::.:.:..|...:....:......:.|.:|:|||::.:|..:  ..:
 Frog   234 TLISVILTVYDLRQQSVKLNRLVESNNSASVTVLMKDGDSYDVESRQLVPGDIIVLTGKR--FFL 296

  Fly   341 PCDLVILRGSCIVDESMLTGESVPLMKESLESLDNLDV-EMDAEGDGKLFVLFGGTKVVQHTAPT 404
            |||.::|.|||||:|.||||||:|:.|..|:..::... ::.:..|.|..|||.||:|:|.|:..
 Frog   297 PCDCILLEGSCIVNEGMLTGESIPVTKTPLDRSESAKPWKIQSGEDYKRHVLFCGTEVIQATSTG 361

  Fly   405 KESLRAPDGGCIGYVIRTGFNTSQGKLLRTILFGANRATENNVETFAFIAFLMVFAVAAASYVW- 468
            .:.:.|       .|::|||||::|.::|:||:......:...:...|:..|:|  :||..:::
 Frog   362 ADPVTA-------VVVQTGFNTAKGDMVRSILYPKPMNFKLYQDALRFLMCLVV--IAAVGFIYS 417

  Fly   469 -----VKGSEDPERNRYKLFLECTLILTSIIPPDLPIELTLAVNTSLIQLTKLFVFCTEPFRIPF 528
                 |||:...:     :.::..:.:|..|||.||..:..|:..|..:|.|..:||..|.||..
 Frog   418 VIVFKVKGASVRD-----IIIKSIIAITVAIPPILPAAVATALMYSQKRLKKKKIFCISPQRINV 477

  Fly   529 AGKVQICCFDKTGTLTTDNLMVEGIAGLAPNGACVPIEK----AEGNTVQ------VLACCHSLA 583
            .|:|.:.|||||||||.|.|.:.|:.....|    ..:|    |:||.:.      .:|.||||.
 Frog   478 CGRVNLVCFDKTGTLTEDGLDLWGVIPCTEN----RFQKLHMFADGNDLPWCPLLGAMASCHSLL 538

  Fly   584 LLDDGLVGDPLEKATLAAVDWTLTKMDS--------VIPKRPQFKP-----LKIIQRYHFSSALK 635
            :||..:.||||:.......:|.:...::        :|...|:..|     :.|:|::.|||:|:
 Frog   539 ILDGKIQGDPLDVKMFEGTNWIIEDSNTENNHNHNLLIKPGPRCSPVPVKGITILQQFPFSSSLQ 603

  Fly   636 RMSVLAGHLIPYSNEVKHIGAVKGAPEVIQK--MLREVPADYEKVYLEYARRGARVLALGIKDLG 698
            ||||:|..:....|.|    .:|||||::.:  :...|||::......|.::|.||:.|..|.|.
 Frog   604 RMSVIAQAIESEENMV----FMKGAPEMVTQFCLPESVPANFANELQLYTQQGYRVIGLAYKPLQ 664

  Fly   699 TLGAQRVREMKREEVECDLTFAGFLIISCPMKPDSKSVIKELIQSSHKVVMITGDSPLTACHVAR 763
            ...........||||||.|.|.|.||:...:|.::...:.||..:..|.||||||:..||..|||
 Frog   665 ACDKGHKENYLREEVECSLIFLGLLILENRLKTETIPALNELNNALIKTVMITGDNLQTAITVAR 729

  Fly   764 ELRFT-RKKLIILTPPEEDRKN---NWSWVSID------GDQSYELDTKPGS---KKLSHLLA-- 813
            ..... |...:||....|...:   :.:|..::      .|.:...|.:..|   |...:..|
 Frog   730 SCGIVQRHGRVILAEASEPNGSIPASITWKEVETNLHVVHDNTETTDPEKNSDAQKSCPYYFAMS 794

  Fly   814 --THDLCITGEGLQYLQQNQPQYMRQLLPQI----TVCARFAPKQKELVITQLKQLGYCTLMCGD 872
              |:.:.:             ||...|||::    .:.||.:|.||..:|.:.::|.|...||||
 Frog   795 GKTYGIIV-------------QYFYSLLPKLLLNGAIFARMSPGQKANLIEEFQKLDYYVAMCGD 846

  Fly   873 GTNDVGALKHANVGVSLLTSAPVKRKRTEEEQQQAAANAAAIAAQAQANANQQLTTRERALRRRQ 937
            |.||.||||.|:.|:||          :|:|
 Frog   847 GANDCGALKMAHAGISL----------SEQE---------------------------------- 867

  Fly   938 EHLNQTQARLQNALRDMEEQTMVKLGDASIAAPFTSKSSSIMCVNHIIKQGRCTLVTTLQMFKIL 1002
                                       ||:|:||||::::|:||..:||:||..||::..:||.:
 Frog   868 ---------------------------ASVASPFTSQTANILCVPQLIKEGRAALVSSFAVFKYV 905

  Fly  1003 ALNALIQAYCQSVLY----IDGI---KFSDTQATMQGIFIAACFLFITRAKPLKTLSKVAP---- 1056
            .|.::||..|..:||    :.|:   .|.|.     ||.|... |.::...|.:.|:...|
 Frog   906 TLYSMIQFICMLLLYWKLKMVGLYQYLFQDV-----GITILVS-LTLSLTHPYQKLAPYRPPAQL 964

  Fly  1057 ------LPNIFNFYTISTILSQFAVHFGTL------YYLTSQANILAPPREGKVKLYIDMD---- 1105
                  |..|||.  :.::.||..   |.|      :|.||.....||..|....:..::.
 Frog   965 ISPPLLLSIIFNI--LLSLASQIC---GFLLVQQQPWYSTSNYRACAPTTENITAVGFNISNTNS 1024

  Fly  1106 --AEEKTKYDPNIVSSTVYIICLSLQVATIAVNYKGYPFMESLRSNRML--MYAIGASAALVILL 1166
              .||..::: |..|:|::.|.....:....|..||.||.:.:.:|.:.  :..|..:|.|.||.
 Frog  1025 TGVEENPEFE-NYESTTLWPITTINLIIVAFVFSKGTPFRKPIYTNYLFFCLLPIQLAACLFILF 1088

  Fly  1167 STGLAPELTEFFEIIDFPTDFRKTLLGVLVLDIVGAFLLDRICSFLFGETRR 1218
            :.  ...|...|::|..||.:|.::|.::::..:.:|.::.    ||.|.||
 Frog  1089 AD--LKGLYRAFQLICTPTIWRISILIIVLIYFLVSFAVEE----LFIENRR 1134

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6230	NP_609490.1	P-type_ATPase_cation	220..1152	CDD:319843	280/1016 (28%)
atp13a5	XP_012818836.2	P5-ATPase	18..141	CDD:463565	21/96 (22%)
		P-type_ATPase_cation	174..997	CDD:319842	264/942 (28%)