Protein Alignment Idua and IDUA

DIOPT Version :10

• Sequence 1: NP_609489.1
• Gene: Idua / 34544
• FlyBaseID: FBgn0032343
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: XP_054205907.1
• Gene: IDUA / 3425
• HGNCID: 5391
• Length: 722
• Species: Homo sapiens
• Alignment Length: 767
• Identity: 205/767 - (26%)
• Similarity: 305/767 - (39%)
• Gaps: 200/767 - (26%)

  Fly     1 MLSLLLVLTTLARIHA-HYTSGDVVYHTMP--HFWTGVGFCPAGRIDHEGISAALGDPALRLNLR 62
            :|:.||....:|...| |....|......|  .||...||||.  :.|......:.....:|||.
Human    13 LLASLLAAPPVAPAEAPHLVQVDAARALWPLRRFWRSTGFCPP--LPHSQADQYVLSWDQQLNLA 75

  Fly    63 LIAALPVGAVTHIRIHWLLELIQFWQYDPSGIPIYDFSKFDDFIDFLHEELRLSPVLEWMGNLGG 127
            .:.|:|...:..:|.||||||:........|:. |:|:..|.::|.|.|. :|.|..|.||:..|
Human    76 YVGAVPHRGIKQVRTHWLLELVTTRGSTGRGLS-YNFTHLDGYLDLLREN-QLLPGFELMGSASG 138

  Fly   128 VFSE-NPMQQSFYWEHLVKTTINHQIARHGSSRLVNWRYETWNEPDLRGYNKQNFTAHTFLDYVQ 191
            .|:: ...||.|.|:.||.:.....|.|:|.:.:..|.:|||||||...::..:.|...||:|..
Human   139 HFTDFEDKQQVFEWKDLVSSLARRYIGRYGLAHVSKWNFETWNEPDHHDFDNVSMTMQGFLNYYD 203

  Fly   192 AVRRGLSKAGNLDNQDGKVPLPMYRSLRGPAGLFKDSNH-----PLCWNLLELCSQRVVY----- 246
            |...||..|.           |..| |.||.    ||.|     ||.|.||..|.....:
Human   204 ACSEGLRAAS-----------PALR-LGGPG----DSFHTPPRSPLSWGLLRHCHDGTNFFTGEA 252

  Fly   247 -CPIDILTFHRKGIEGTATEIVNGSLSLMAKIYEE------------------------------ 280
             ..:|.::.|||......:..|..:||..|....:
Human   253 GVRLDYISLHRKVRPAPPSAPVFCALSRCAPGRADPGGAEAAPPAGCAQLHLHPGAGEGRRAADP 317

  Fly   281 --------YPNLKQ--------LPV------------------ANDEADPVAGWSTSRDFQADV- 310
                    :|:|::        :|.                  |...|.|.|.:...||.:|..
Human   318 AALPQVRGHPHLQRRGGPAGGLVPATAVEGGRDLRGHGGEGGPAQRPARPPATFLPRRDRRAVAA 382

  Fly   311 ---------------RYGITLISTVMQFWHAKLAGGPLSRLESISHDNAFLSYHPHEFTQRTLLA 360
                           ...:.|.:|...|.:|.|           |:||||||||||.|.||||.|
Human   383 PPGPSCPGHPQVIAQHQNLLLANTTSAFPYALL-----------SNDNAFLSYHPHPFAQRTLTA 436

  Fly   361 HFRMNETKPPHSQLVQKPVYAALGMLAKLGTRA--ADVEMVN--MDTKHSVQVLRTVSGGLGGPG 421
            .|::|.|:|||.||::|||..|:|:||.|....  |:|....  :|:.|:|.||.:.....|...
Human   437 RFQVNNTRPPHVQLLRKPVLTAMGLLALLDEEQLWAEVSQAGTVLDSNHTVGVLASAHRPQGPAD 501

  Fly   422 QYMATIFLSPEEAGPKMTAFHHKYTLNMSIANESAFVTELL--VPKETDPYYI------------ 472
            .:.|.:.:...:.    |..|         .|.|..||..|  ||......|:
Human   502 AWRAAVLIYASDD----TRAH---------PNRSVAVTLRLRGVPPGPGLVYVTRYLDNGLCSPD 553

  Fly   473 --WQQAGSPAYPNATLREAMRRAQ-----APRLYKTGPIWQYNSELVINSASIPLPWAMLLRVCS 530
              |::.|.|.:|.|.....||.|:     |||....|      ..|.:..| :.||..:|:.||:
Human   554 GEWRRLGRPVFPTAEQFRRMRAAEDPVAAAPRPLPAG------GRLTLRPA-LRLPSLLLVHVCA 611

  Fly   531 ASWPKLRRPQ-------QLSIAEVTQREVFISWMEHPKSTQCLLSYEVWFKERDNLGRSADWMLI 588
                   ||:       :|....:||.::.:.|.:....::||.:||:.|.:.   |::  :..:
Human   612 -------RPEKPPGQVTRLRALPLTQGQLVLVWSDEHVGSKCLWTYEIQFSQD---GKA--YTPV 664

  Fly   589 SQGWHLPYPS----FQYAPGDKGSVNGFYKVRGVDVFNETSPYSQIVEYLEL 636
            |:     .||    |.::| |.|:|:|.|:||.:|.:....|:|..|.|||:
Human   665 SR-----KPSTFNLFVFSP-DTGAVSGSYRVRALDYWARPGPFSDPVPYLEV 710

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Idua	NP_609489.1	Glycosyl hydrolases	31..497	CDD:474034	156/582 (27%)
IDUA	XP_054205907.1	Glycosyl hydrolases	30..594	CDD:474034	162/613 (26%)
		FN3	<616..>719	CDD:442628	29/106 (27%)