DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)gd1 and CC2D1A

DIOPT Version :9

Sequence 1:	NP_001245976.1	Gene:	l(2)gd1 / 34543	FlyBaseID:	FBgn0261983	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	XP_024307330.1	Gene:	CC2D1A / 54862	HGNCID:	30237	Length:	982	Species:	Homo sapiens

Alignment Length:	902	Identity:	311/902 - (34%)
Similarity:	465/902 - (51%)	Gaps:	161/902 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFSRKKPE------PAKRRQ----HDLSQFGLTEIPDDFDPSAGYGEDDGGDSDLEAELAAITGG 55
            |..||.|.      .|..||    .|||..||. ||          ||...|.:||||..|:.||
Human     1 MHKRKGPPGPPGRGAAAARQLGLLVDLSPDGLM-IP----------EDGANDEELEAEFLALVGG 54

  Fly    56 E-GAKPKPKPKAKLLPASDLDKMIADSLRDVSDDD----DDDNLESDPDLLGELSGIGGLEE--A 113
            : .|..|.|.|.. ||...::||.:..:||..:|:    |:|:||:|.|||.||:.:.|.|:  :
Human    55 QPPALEKLKGKGP-LPMEAIEKMASLCMRDPDEDEEEGTDEDDLEADDDLLAELNEVLGEEQKAS 118

  Fly   114 EEEEPVAQPPAASEEPVQTFLPTTTVDTLSIIKQRLEMYKQAEANAKTAGDSGKARRFGRGLKTL 178
            |...|||||...:..|   .|.||       :::||.:|:.|..:|:.||||.|.||:.||||||
Human   119 ETPPPVAQPKPEAPHP---GLETT-------LQERLALYQTAIESARQAGDSAKMRRYDRGLKTL 173

  Fly   179 KDLHRQAAAGKSINVDDIPPEVSVKPIGGQAPPVPAEESPAPSTPASPPPVPSRAAPDP------ 237
            ::|......|.:|:..||||.|::    |:.|......||||:.||  |.:.|  ||:|
Human   174 ENLLASIRKGNAIDEADIPPPVAI----GKGPASTPTYSPAPTQPA--PRIAS--APEPRVTLEG 230

  Fly   238 PTPGTPVEPTTSVAPTSPPNPL----VTQMRSRQTDYKAAALQSKRSGDISTALQFLKVVKQFDV 298
            |:...|........|..||.|.    :.|::|||.|||.|||.:|:.||.:.|.:..:|.|.||.
Human   231 PSATAPASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDA 295

  Fly   299 VIKMCEDGQEVDLSDMPPPPAEFLEFLKKMQEEAAAEAVAEPTAAPEPTPVAPAPVLAAAT---- 359
            |::....|:.||||.:||||.:.                  |...|.|....|.|..|.:|
Human   296 VLEALSRGEPVDLSCLPPPPDQL------------------PPDPPSPPSQPPTPATAPSTTEVP 342

  Fly   360 ----NMLEALQQRLEKYQSVEAAAKAENNSGKARRFGRIVKQYEDAIKLYKAGKPVPYDELPVPP 420
                .:||||:||:|:||...|.||::.:..|||...||||||:|||:.:|||:.|...||||||
Human   343 PPPRTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPP 407

  Fly   421 GFGPL-------PT----------------ADAAPVAPTPSLPTSPTSP-PPTASTSA--GGTPS 459
            ||.|:       ||                .|..|......:|....|| .|||...|  ..||.
Human   408 GFPPIQGLEATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQ 472

  Fly   460 SSSATTPTAPRKAPSPPKPKELTTRTSGNQQKNNIAEQQMKLLLERQKEFKLAAIEAKKAGEIDQ 524
            |.||  |||  |||    ||..:||          |:||:..|..|:|:...||:.||:..:::.
Human   473 SGSA--PTA--KAP----PKATSTR----------AQQQLAFLEGRKKQLLQAALRAKQKNDVEG 519

  Fly   525 AKEYLKIFKGFDSLLNAASSGLPVDLSTLPVPPSQRDNLEASFAIVSAEECDPTDDICEIGVRME 589
            ||.:|:..||.:.:|.|:.:|||||::.:|..|..:|:    ||:|..    |...:.:...|..
Human   520 AKMHLRQAKGLEPMLEASRNGLPVDITKVPPAPVNKDD----FALVQR----PGPGLSQEAARRY 576

  Fly   590 EQLAK----QLMMCKNTRDHHKAMGDVAGMNRFENLALTVQKDLDLVRYSKRKNEPLPKFHYEKR 650
            .:|.|    |..||.|..:....:|::....:||.||...::.:|:::.:..:..|.|...:|:|
Human   577 GELTKLIRQQHEMCLNHSNQFTQLGNITETTKFEKLAEDCKRSMDILKQAFVRGLPTPTARFEQR 641

  Fly   651 SFNIVHCNTDLTDSELEIVVVRGISYNV---ANPKDVDTYVRVEFPLLN-DESFKTKTNVIRDTS 711
            :|:::....||:.:::.:.:|:||:...   .:|.|:|.:||.:||..| :|:.|.||:||::|.
Human   642 TFSVIKIFPDLSSNDMLLFIVKGINLPTPPGLSPGDLDVFVRFDFPYPNVEEAQKDKTSVIKNTD 706

  Fly   712 SPDYDERFKVDIQRTNRQFQRIFKRHGVKFEIYSRGCSIDCCGLSRKLPLCCFRGFLRSDTLIGT 776
            ||::.|:||:.|.|::|.|:|..:..|:|||:..:|                  |..::|.::||
Human   707 SPEFKEQFKLCINRSHRGFRRAIQTKGIKFEVVHKG------------------GLFKTDRVLGT 753

  Fly   777 VNVKLQPLETKCEIHDTYDLMDGRKQVGGKLEVKIRVRNPILTKQMEHITEKWLVLD 833
            ..:||..||..||:.:..:::|||:..||:|||.:|:|.|:..:|:|..||:|||:|
Human   754 AQLKLDALEIACEVREILEVLDGRRPTGGRLEVMVRIREPLTAQQLETTTERWLVID 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)gd1	NP_001245976.1	DM14	142..200	CDD:128928	25/57 (44%)
		DM14	260..318	CDD:128928	26/57 (46%)
		DM14	362..420	CDD:128928	32/57 (56%)
		DM14	499..557	CDD:128928	20/57 (35%)
		C2_Freud-1	661..832	CDD:176072	61/174 (35%)
CC2D1A	XP_024307330.1	Atrophin-1	<116..477	CDD:331285	143/398 (36%)
		DM14	140..195	CDD:128928	25/54 (46%)
		DM14	257..310	CDD:128928	23/52 (44%)
		DM14	349..407	CDD:128928	32/57 (56%)
		DM14	494..552	CDD:128928	20/57 (35%)
		C2_Freud-1	652..809	CDD:176072	61/174 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158220
Domainoid	1	1.000	326	1.000	Domainoid score	I1184
eggNOG	1	0.900	-	-		E1_KOG3837
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H23040
Inparanoid	1	1.050	470	1.000	Inparanoid score	I1526
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49459
OrthoDB	1	1.010	-	-		D408012at33208
OrthoFinder	1	1.000	-	-		FOG0003388
OrthoInspector	1	1.000	-	-		otm41354
orthoMCL	1	0.900	-	-		OOG6_104069
Panther	1	1.100	-	-	LDO	PTHR13076
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4491
SonicParanoid	1	1.000	-	-		X2281
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800