DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)gd1 and Cc2d1b

DIOPT Version :9

Sequence 1:	NP_001245976.1	Gene:	l(2)gd1 / 34543	FlyBaseID:	FBgn0261983	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	NP_796019.1	Gene:	Cc2d1b / 319965	MGIID:	2443076	Length:	848	Species:	Mus musculus

Alignment Length:	880	Identity:	291/880 - (33%)
Similarity:	471/880 - (53%)	Gaps:	92/880 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RKKPEPAKRRQHDLSQFGL-TEI-PDDFDPSAGYGEDDGGDSDLEAELAAITG---GEGAKPKPK 63
            ||.|:.:.:......|.|| .|. |:|........||||   ||||||.|:||   ....||.||
Mouse     7 RKGPKTSGQGAETAKQLGLFVEFNPEDMLLGVDETEDDG---DLEAELLALTGETASRSRKPAPK 68

  Fly    64 PKAKLLPASDLDKMIADSLRDVSDDDDDDNLESDPDLLGELSGIGGLEEAEEEE-------PVAQ 121
            .:|. ||.:.::|:.||.:|||.:|::::.||.|.|||.||..:.|    |:||       ..|.
Mouse    69 GQAP-LPMAHIEKLAADCMRDVEEDEEEEGLEDDADLLTELQEVLG----EDEEAGLLDGSEAAS 128

  Fly   122 PPAASEE-------PVQTFLPTTTVDTL----------SIIKQRLEMYKQAEANAKTAGDSGKAR 169
            |....|:       ||:.......|...          :::::|:..|::|.|:||.||::.|||
Mouse   129 PDLCEEKTWDNTELPVEQAACQQAVPAAAQAGGPRGLQALLEERIRNYREAAASAKEAGEAAKAR 193

  Fly   170 RFGRGLKTLKDLHRQAAAGKSINVDDIPPEVSVKPIGGQAPPVPAEESPAPSTPASPPPVPSRAA 234
            |..||||||:........|..|..|:|||.|::    |:.||.|.|.  |...|....|.|  .|
Mouse   194 RCERGLKTLQSQLATVRKGGKICEDEIPPPVAL----GKRPPAPQER--AIKNPEIDSPGP--CA 250

  Fly   235 PDPPTPGTPVEPTTSVA--PTSPPNPLVTQMRSRQTDYKAAALQSKRSGDISTALQFLKVVKQFD 297
            .:|.....|.....::|  |.|.|:|... :.:||.:||||||.:||:||:..|.:.:::.|:|.
Mouse   251 MEPGNLSQPESSLPAIAPLPDSDPDPQAL-LLARQREYKAAALDAKRAGDLDRARELMRIGKRFG 314

  Fly   298 VVIKMCEDGQEVDLSDMPPPPAEFLEFLKKMQEEAAAEAVAEPTAAPEP--------TPVAPAPV 354
            .|::..|.||.||||.|||.||:.....:..:..:|.:.::......:|        |||||
Mouse   315 TVLEALEKGQPVDLSGMPPAPADLKALPQASKASSATQGLSPAVEQMQPVMASDLPATPVAP--- 376

  Fly   355 LAAATNMLEALQQRLEKYQSVEAAAKAENNSGKARRFGRIVKQYEDAIKLYKAGKPVPYDELPVP 419
             |..|.:|:||||||.||:.....|:|..:..|||...||.|||:||::.::||:.|.:.|||||
Mouse   377 -AEPTTVLDALQQRLNKYREAGIQARANGDERKARMHDRIAKQYQDAVRAHQAGQKVDFAELPVP 440

  Fly   420 PGFGPLPTADAAPVAPTPSLPTSPTSPPPTASTSAG----GTPSSSSATTPTAPRKAPSPPKPKE 480
            |||.|:|..:....:...|:..:..:....||..|.    ...|.:.|..|.|.:.|.:...|..
Mouse   441 PGFPPIPGLEPRKGSEQDSVAATLATAQKLASEDAALVDDDEESDTPAQAPLAKKPAQTLVSPSH 505

  Fly   481 LTTRTSGNQQKNNIA---EQQMKLLLERQKEFKLAAIEAKKAGEIDQAKEYLKIFKGFDSLLNAA 542
            |.|....:..|.:::   .:|:.||..|:.:::.||::||:..:::|||.:|::.|..::.:..|
Mouse   506 LLTEPKASSSKESLSPSVREQVTLLEARKLQYQRAALQAKRRQDLEQAKSHLRVAKSLEAQIIQA 570

  Fly   543 SSGLPVDLSTLPVPPSQRDNLEASFAIVSAEECDPTDDICEIGVRMEEQLAKQLMMCKNTRDHHK 607
            .:|.|:|||.:|.|.:..   |..|.::..|:...:....|:..::::.|.:|...|......:.
Mouse   571 RAGQPIDLSKVPSPLTDE---EGDFILIHHEDLRLSQKAEEVYAQLQKMLQEQQAKCLLFSKQYM 632

  Fly   608 AMGDVAGMNRFENLALTVQKDLDLVRYSKRKNEPLPKFHYEKRSFNIVHCNTDLTDSELEIVVVR 672
            ..|:||...|||.||...:|.|::::.::.:....|..|:|.::|..|...::|..:|:.:::||
Mouse   633 HQGNVAETTRFERLAEDRKKQLEILQLAQAQGLDPPSHHFELKTFQTVRIFSELNSTEMHLIIVR 697

  Fly   673 GISYNV---ANPKDVDTYVRVEFPLLN-DESFKTKTNVIRDTSSPDYDERFKVDIQRTNRQFQRI 733
            |::...   ..|.|:|.:||.||...| |::.|:||.|:::|:||::::.||::|.|.:|.|:|:
Mouse   698 GMNLPAPPGVTPDDLDAFVRFEFHYPNSDQAQKSKTAVVKNTNSPEFEQVFKLNINRNHRGFRRV 762

  Fly   734 FKRHGVKFEIYSRGCSIDCCGLSRKLPLCCFRGFLRSDTLIGTVNVKLQPLETKCEIHDTYDLMD 798
            .:..|:||||:.:|                  .|.|||.|:||.::||:.||.:|||.:..:::|
Mouse   763 IQSKGIKFEIFHKG------------------SFFRSDKLVGTAHLKLERLEKECEIREIMEVLD 809

  Fly   799 GRKQVGGKLEVKIRVRNPILTKQMEHITEKWLVLD 833
            |||..|||||||:|:|.|:.::.::.:||.||||:
Mouse   810 GRKPTGGKLEVKVRLREPLSSQDVQTVTENWLVLE 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)gd1	NP_001245976.1	DM14	142..200	CDD:128928	24/67 (36%)
		DM14	260..318	CDD:128928	26/57 (46%)
		DM14	362..420	CDD:128928	28/57 (49%)
		DM14	499..557	CDD:128928	19/57 (33%)
		C2_Freud-1	661..832	CDD:176072	66/174 (38%)
Cc2d1b	NP_796019.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		3/13 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	53..75		9/22 (41%)
		DM14	167..224	CDD:128928	24/56 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	217..276		21/66 (32%)
		DM14	278..335	CDD:128928	26/57 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	326..353		10/26 (38%)
		DM14	383..437	CDD:128928	24/53 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	433..460		10/26 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..523		9/46 (20%)
		DM14	527..584	CDD:128928	19/56 (34%)
		C2_Freud-1	686..843	CDD:176072	66/174 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848602
Domainoid	1	1.000	321	1.000	Domainoid score	I1226
eggNOG	1	0.900	-	-		E1_KOG3837
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	463	1.000	Inparanoid score	I1535
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49459
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003388
OrthoInspector	1	1.000	-	-		otm43411
orthoMCL	1	0.900	-	-		OOG6_104069
Panther	1	1.100	-	-	O	PTHR13076
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2281
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.760