DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)gd1 and Cc2d1b

DIOPT Version :9

Sequence 1:	NP_001245976.1	Gene:	l(2)gd1 / 34543	FlyBaseID:	FBgn0261983	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	NP_001257913.1	Gene:	Cc2d1b / 313478	RGDID:	1306630	Length:	850	Species:	Rattus norvegicus

Alignment Length:	899	Identity:	296/899 - (32%)
Similarity:	473/899 - (52%)	Gaps:	128/899 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RKKPEPAKRRQHDLSQFGL-TEI-PDDFDPSAGYGEDDGGDSDLEAELAAITGGEGA---KPKPK 63
            ||.|:.:.:......|.|| .|. |:|........||||   ||||||.|:||..|:   ||.||
  Rat     7 RKGPKTSGQGAETAKQLGLFVEFNPEDMLLGMDETEDDG---DLEAELLALTGETGSTSRKPAPK 68

  Fly    64 PKAKLLPASDLDKMIADSLRDVSDD-DDDDNLESDPDLLGELSGIGGLEE--------------- 112
            .:|. ||.:.::|:.||.:|||.:: ::::.||.|.|||.||..:.|::|
  Rat    69 GRAP-LPMAHIEKLAADCMRDVEEEGEEEEGLEDDADLLTELQEVLGVDEETGLVDDSEETSPDL 132

  Fly   113 AEE------EEPVAQPPAASEEPVQTFLPTTTVDT------LSIIKQRLEMYKQAEANAKTAGDS 165
            :||      |:|||  |||    .|..||......      .:::::|::.|::|.|:||.||::
  Rat   133 SEEKTRDNTEQPVA--PAA----FQQALPAAVAQAGGPRGLQALLEERIQNYREAAASAKEAGEA 191

  Fly   166 GKARRFGRGLKTLKDLHRQAAAGKSINVDDIPPEVSVKPIGGQAPPV----PAEESPAPSTPASP 226
            .||||..||||||:........|..|..|:|||.|::    |:.||.    |:::|...|.
  Rat   192 AKARRCERGLKTLESQLATVRKGGKICEDEIPPPVAL----GKRPPAHQERPSKDSEIDSA---- 248

  Fly   227 PPVPSRAAPDPPTPGTPVE--PTTSVAPTSPPNPLVTQMRSRQTDYKAAALQSKRSGDISTALQF 289
                ...|.||.....|..  |..:..|.|.|:|... :.:||.:||||||.:||:||:..|.:.
  Rat   249 ----GSCAMDPGDLSQPESSLPAVAALPDSDPDPQAL-LLARQREYKAAALSAKRAGDLDRAREL 308

  Fly   290 LKVVKQFDVVIKMCEDGQEVDLSDMPPPPAEFLEFLKKMQEEAAAEAVAEPTAAP-EP------- 346
            :::.|:|..|::..|.||.||||.|||.| |.|:.|.:..|.:||..|..|.... :|
  Rat   309 MRIGKRFGTVLEALEKGQPVDLSGMPPAP-EDLKALPQASEASAATQVLSPAVEQMQPVMSSDLP 372

  Fly   347 -TPVAPAPVLAAATNMLEALQQRLEKYQSVEAAAKAENNSGKARRFGRIVKQYEDAIKLYKAGKP 410
             ||.||    |....:|:||||||.:|:.....|:|..:..|||...||.|||:|||:.::||:.
  Rat   373 ATPAAP----AEPKTVLDALQQRLNRYREAGIQARASGDERKARMHDRIAKQYQDAIRAHQAGRK 433

  Fly   411 VPYDELPVPPGFGPLPTADAAPVAPTPSLPTSPTSPPPTASTSAGGTPSSSSATT-------PTA 468
            |.:.||||||||.|:|..:          |...|......:|.|.....:|..|.       ...
  Rat   434 VDFAELPVPPGFPPIPGLE----------PRKDTEEDSVTATLAAAQKLASEDTALVDEDEERDT 488

  Fly   469 PRKAPSPPKPKE-------LTTRTSGNQQKNNIA---EQQMKLLLERQKEFKLAAIEAKKAGEID 523
            |.:||...||.:       |......:..|.:::   .:|:.||..|:.:::.||::||:..:::
  Rat   489 PAQAPLAKKPAQPLVPSSHLLNEPKASSSKESLSPSVREQVTLLEARKLQYQRAALQAKRRQDLE 553

  Fly   524 QAKEYLKIFKGFDSLLNAASSGLPVDLSTLPVPPSQRDNLEASFAIVSAEECDPTDDICEIGVRM 588
            |||.:|::.|..::.:..|.:|.|:|||.:|.|.:..   |..|.::..|:...:....|:..::
  Rat   554 QAKSHLRVAKSLEAQIIQARAGQPIDLSKVPSPLTDE---EGDFILIHHEDLRLSQKAEEVYAQL 615

  Fly   589 EEQLAKQLMMCKNTRDHHKAMGDVAGMNRFENLALTVQKDLDLVRYSKRKNEPLPKFHYEKRSFN 653
            ::.|.:|...|..........|:||...|||.||...:|.|::::.::.:....|..|:|.::..
  Rat   616 QKILLEQHEKCLLFSKQFMHQGNVAETTRFEKLAEDRKKQLEILQLAQAQGLDPPSHHFELKTLQ 680

  Fly   654 IVHCNTDLTDSELEIVVVRGISYNV---ANPKDVDTYVRVEFPLLN-DESFKTKTNVIRDTSSPD 714
            .|...::|..:|:.:::|||::...   ..|.|:|.:||.||...| |::.|:||.|:::|:||:
  Rat   681 TVRIFSELNSTEMHLIIVRGMNLPAPPGVTPDDLDAFVRFEFHYPNSDQAQKSKTAVVKNTNSPE 745

  Fly   715 YDERFKVDIQRTNRQFQRIFKRHGVKFEIYSRGCSIDCCGLSRKLPLCCFRGFLRSDTLIGTVNV 779
            :::.||::|.|.:|.|:|:.:..|:||||:.:|                  .|.|||.|:||.::
  Rat   746 FEQVFKLNINRNHRGFRRVIQSKGIKFEIFHKG------------------SFFRSDKLVGTAHL 792

  Fly   780 KLQPLETKCEIHDTYDLMDGRKQVGGKLEVKIRVRNPILTKQMEHITEKWLVLD 833
            ||:.||.:|||.:..:::||||..|||||||:|:|.|:.::.::.:||.||||:
  Rat   793 KLERLEKECEIREIMEVLDGRKPTGGKLEVKVRLREPLSSQDVQMVTENWLVLE 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)gd1	NP_001245976.1	DM14	142..200	CDD:128928	24/57 (42%)
		DM14	260..318	CDD:128928	26/57 (46%)
		DM14	362..420	CDD:128928	28/57 (49%)
		DM14	499..557	CDD:128928	19/57 (33%)
		C2_Freud-1	661..832	CDD:176072	66/174 (38%)
Cc2d1b	NP_001257913.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		3/13 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	54..73		8/19 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	114..145		5/30 (17%)
		DM14	169..226	CDD:128928	24/56 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..277		19/73 (26%)
		DM14	280..337	CDD:128928	26/57 (46%)
		DM14	385..439	CDD:128928	24/53 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	436..525		23/98 (23%)
		DM14	529..586	CDD:128928	19/56 (34%)
		C2_Freud-1	688..845	CDD:176072	66/174 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352201
Domainoid	1	1.000	307	1.000	Domainoid score	I1304
eggNOG	1	0.900	-	-		E1_KOG3837
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	446	1.000	Inparanoid score	I1577
OMA	1	1.010	-	-		QHG49459
OrthoDB	1	1.010	-	-		D408012at33208
OrthoFinder	1	1.000	-	-		FOG0003388
OrthoInspector	1	1.000	-	-		otm45480
orthoMCL	1	0.900	-	-		OOG6_104069
Panther	1	1.100	-	-	O	PTHR13076
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2281
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770