DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)gd1 and Cc2d1a

DIOPT Version :9

Sequence 1:	NP_001245976.1	Gene:	l(2)gd1 / 34543	FlyBaseID:	FBgn0261983	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	XP_038953459.1	Gene:	Cc2d1a / 288908	RGDID:	1306108	Length:	1026	Species:	Rattus norvegicus

Alignment Length:	886	Identity:	297/886 - (33%)
Similarity:	463/886 - (52%)	Gaps:	137/886 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFSRKKPE-PAKRRQHDLSQFGLTEIPDDFDPSAGYGEDDG-GDSDLEAELAAITGGEGAKPKPK 63
            |..|..|: |..|......|.||..   ||.|......:|| .|.:||||..|:.||:     |:
  Rat     1 MHKRNGPQAPPGRGAVTARQLGLLV---DFSPDGLMIPEDGVNDEELEAEFLALVGGQ-----PQ 57

  Fly    64 PKAKL-----LPASDLDKMIADSLRDVSDDDD--DDNLESDPDLLGELSGIGGLEE--AEEEEPV 119
            ...||     ||...::||....:||:.:|::  |:::|:|.|||.||:.:.|.|.  .|...||
  Rat    58 ALEKLKGKGPLPMEAIEKMARLCMRDLDEDEEGTDEDVEADEDLLAELNEVLGEERKAVEPAMPV 122

  Fly   120 AQPPAASEEPVQTFLPTTTVDTLSIIKQRLEMYKQAEANAKTAGDSGKARRFGRGLKTLKDLHRQ 184
            .||..:|..|          ...:.:::||.:|:.|..:|:.||||.|.||:.||||||::|...
  Rat   123 VQPKPSSPNP----------GIEATLQERLILYQSAVESARQAGDSAKMRRYDRGLKTLENLLVS 177

  Fly   185 AAAGKSINVDDIPPEVSVKPIGGQAPPVPAEESPAPS--TPASPP-PVPSRAAPDPPTPG-TPVE 245
            |..|.:||..||||.|:    .|:.|.:....:...|  .|.||| |.||.....|.|.. |..:
  Rat   178 AKKGNTINEADIPPPVA----SGKGPAIGHSHTHTTSHLAPVSPPAPEPSVTLEAPSTTAQTSAK 238

  Fly   246 PTTSVAPTSPPNPLVTQMRSRQTDYKAAALQSKRSGDISTALQFLKVVKQFDVVIKMCEDGQEVD 310
            |..|..|.||    :.:::|.|.:||.|||::|...|.:||.::|:|.|.||.|::....|:.||
  Rat   239 PQLSPDPCSP----LARLQSLQHEYKVAALRAKHQDDTATAARYLRVSKSFDPVLEALSRGELVD 299

  Fly   311 LSDMPPPPAEFLEFLKKMQEEAAAEAVAEPTAAPEPTPVAPAPVLAAAT-----------NMLEA 364
            ||.:||||.:.                     :|||...|..||..|:|           |:|||
  Rat   300 LSRLPPPPDQL---------------------SPEPPLPAAQPVTPASTLTRPEVPQPPKNLLEA 343

  Fly   365 LQQRLEKYQSVEAAAKAENNSGKARRFGRIVKQYEDAIKLYKAGKPVPYDELPVPPGFGPLPTAD 429
            |:||:|:|....|.|||:.:..|||...||||||:|||:.:|||:.|...||||||||.|:...:
  Rat   344 LEQRMERYHVAAAQAKAKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLE 408

  Fly   430 AAPVAPTPSLPTSPTSPPPTASTSAG------------GTPSSSSATTPTAPRKA-PSPPKP--- 478
            :|..:....:....|: ...|:...|            .||::|:|....:|.:| ||.|.|
  Rat   409 SAEPSQQSLVGVLETA-MKLANHEEGSDEEEEETPKKQNTPAASTAQPKASPSRAPPSGPAPAGK 472

  Fly   479 ---KELTTRTSGNQQKNNIAEQQMKLLLERQKEFKLAAIEAKKAGEIDQAKEYLKIFKGFDSLLN 540
               |..:||          |:||:..|..|:|:...||:.||:..:::.||.:|:..||.:.:|.
  Rat   473 AASKGTSTR----------AQQQLAFLEGRKKQLLQAALRAKQKNDVEGAKMHLRQAKGLEPMLE 527

  Fly   541 AASSGLPVDLSTLPVPPSQRDNLEASFAIVSAEECDPTDDICEIGVRMEEQLAKQLM----MCKN 601
            |:.:|||||::.:|..|..:|:    |.:|..    |...:.:..||...:|.|.|.    ||.|
  Rat   528 ASRNGLPVDIAKVPPAPVNKDD----FVLVQR----PGPGMSQEAVRRYGELTKLLRQQHEMCLN 584

  Fly   602 TRDHHKAMGDVAGMNRFENLALTVQKDLDLVRYSKRKNEPLPKFHYEKRSFNIVHCNTDLTDSEL 666
            .......:|::|...:||.||...::.:|.::.:..::.|.|...:|:|:|:::....||:::::
  Rat   585 HSTQFTHLGNIAETIKFEKLAEDCKRSMDTLKQAFARSLPTPAARFEQRTFSVIKIFPDLSNNDM 649

  Fly   667 EIVVVRGISYNV---ANPKDVDTYVRVEFPLLN-DESFKTKTNVIRDTSSPDYDERFKVDIQRTN 727
            .:.:|:||:...   .:|.|:|.:||.:||..| :|:.|.||:||:.|.||::.|:||:.|.|.:
  Rat   650 LLFIVKGINLPTPPGLSPSDLDAFVRFDFPYPNVEEAQKDKTSVIKSTDSPEFKEQFKLCINRGH 714

  Fly   728 RQFQRIFKRHGVKFEIYSRGCSIDCCGLSRKLPLCCFRGFLRSDTLIGTVNVKLQPLETKCEIHD 792
            |.|:|..:..|:|||:..:|                  |..::|.::||..:||..|||.||:|:
  Rat   715 RGFRRAIQTKGIKFEVVHKG------------------GLFKTDRVLGTAQLKLDTLETACEVHE 761

  Fly   793 TYDLMDGRKQVGGKLEVKIRVRNPILTKQMEHITEKWLVLD 833
            ..:::|||:..||:|||.:|:|.|:..:|:|..||:|||:|
  Rat   762 ILEVLDGRRPTGGRLEVMVRIREPLTAQQLETTTERWLVID 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)gd1	NP_001245976.1	DM14	142..200	CDD:128928	27/57 (47%)
		DM14	260..318	CDD:128928	24/57 (42%)
		DM14	362..420	CDD:128928	32/57 (56%)
		DM14	499..557	CDD:128928	20/57 (35%)
		C2_Freud-1	661..832	CDD:176072	63/174 (36%)
Cc2d1a	XP_038953459.1	DM14	136..193	CDD:128928	27/56 (48%)
		PHA03247	<217..486	CDD:223021	104/304 (34%)
		DM14	249..307	CDD:128928	24/57 (42%)
		DM14	341..399	CDD:128928	32/57 (56%)
		DM14	486..544	CDD:128928	20/57 (35%)
		C2_Freud-1	644..801	CDD:176072	63/174 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352202
Domainoid	1	1.000	307	1.000	Domainoid score	I1304
eggNOG	1	0.900	-	-		E1_KOG3837
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H23040
Inparanoid	1	1.050	446	1.000	Inparanoid score	I1577
OMA	1	1.010	-	-		QHG49459
OrthoDB	1	1.010	-	-		D408012at33208
OrthoFinder	1	1.000	-	-		FOG0003388
OrthoInspector	1	1.000	-	-		otm45480
orthoMCL	1	0.900	-	-		OOG6_104069
Panther	1	1.100	-	-	LDO	PTHR13076
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2281
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770