Protein Alignment Reps and REPS2

DIOPT Version :9

• Sequence 1: NP_609487.2
• Gene: Reps / 34542
• FlyBaseID: FBgn0032341
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: XP_011543905.1
• Gene: REPS2 / 9185
• HGNCID: 9963
• Length: 663
• Species: Homo sapiens
• Alignment Length: 913
• Identity: 220/913 - (24%)
• Similarity: 319/913 - (34%)
• Gaps: 343/913 - (37%)

  Fly     5 LTEPETRFYSELFQCC----------DVEKTGKVPMLKAT-------ELFRSADIANETVIEITG 52
            |:|.|.:.|||||..|          ...:..:|....||       :|||::.:..||:.:||.
Human    30 LSEGEQQCYSELFARCAGAAGGGPGSGPPEAARVAPGTATAAAGPVADLFRASQLPAETLHQITE 94

  Fly    53 LAGIPSTALHISRTQFYSCLKLIAAHQAAMPLRQELILATFPLPLPHFSWK----EAVTAPVAVE 113
            |.|..... :...||||..||||||.|:.:|:|.|.|..  .||||.|...    |......|..
Human    95 LCGAKRVG-YFGPTQFYIALKLIAAAQSGLPVRIESIKC--ELPLPRFMMSKNDGEIRFGNPAEL 156

  Fly   114 NGLTALPPPPPTDRRNSLRRNSQQEQLQDT-----SDVPSTDSEVEQNESVDDATGHGRGTDGCG 173
            :| |.:..|..|..:||.:|...:::.|:|     |.:.|..|.....:.|..:.|:.:
Human   157 HG-TKVQIPYLTTEKNSFKRMDDEDKQQETQSPTMSPLASPPSSPPHYQRVPLSHGYSK------ 214

  Fly   174 VVSSSSRENVGRRRGGGTGGGSPEAWSTNSDSPTPTNSVAERPWAQDTLWQGLLGDEHRQLLGTE 238
              ..||.|.:           .|..:........|..|.:..|..:....|..|    .:....|
Human   215 --LRSSAEQM-----------HPAPYEARQPLVQPEGSSSGGPGTKPLRHQASL----IRSFSVE 262

  Fly   239 EESSDRHSSDDDDNESELVTIYQITPEQREYYNKQFRTVQRDPHGLLSGQAARNFFEKSRIPVEE 303
            .|..|..|..|:.        ::||.||||||..|||::|.||...:||..|:|||.||::.:.|
Human   263 RELQDNSSYPDEP--------WRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPE 319

  Fly   304 LRHIWQLCDVTRDGALSLSEFTAAMHLVVLRRNNIPLPTSLPHCLHPNVLQAAASGSGQGVTSSS 368
            |.:||:|.|...||||:|.||.||.||:|.|:|..|||..||..|.|..||
Human   320 LSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGLPPTLQPEYLQ-------------- 370

  Fly   369 SAALPQEPPEADLLHLNDDDEDDHTDNTIIAGNLSGSSTTSKPRPNVPSDKNIMNLSSISTSSQA 433
             ||.|:  |:.|.                   .|..|.:.|.|....|.|.|.|..:|:
Human   371 -AAFPK--PKWDC-------------------QLFDSYSESLPANQQPRDLNRMEKTSV------ 407

  Fly   434 SNSSKREATPQNSLGKNRSISNSPNVEKPVSGTVSSTASAVDSTNVSSQWTKFSESPTTSAVSVQ 498
                           |:.:....||
Human   408 ---------------KDMADLPVPN---------------------------------------- 417

  Fly   499 STTGAAPVVAAGAAASGASSPGLKPVLFDMKRSAQDVVSNPQILHPVPLRVTPIGTAIASSAESS 563
                                              |||.|:.:                  .|..|
Human   418 ----------------------------------QDVTSDDK------------------QALKS 430

  Fly   564 NENESAVAQREDSPKAISSTTVNNQSSAVVPGISGVAGSSHRDSSDLRAIQRPQAKKLPAKNSAL 628
            ..||:.       ||.:|...                 ::.:||:.|:|  ||:::
Human   431 TINEAL-------PKDVSEDP-----------------ATPKDSNSLKA--RPRSR--------- 460

  Fly   629 PPPPQREPSIGSTGPSESQEPQAAYVASSLASKKEPPPLPPPRPHR-HARSSSLDLNKFKIGATG 692
                    |..||...|:.:            :.|.||.|||||.: |:|:|||||||
Human   461 --------SYSSTSIEEAMK------------RGEDPPTPPPRPQKTHSRASSLDLNK------- 498

  Fly   693 GAQQAEITAQASFDMQTSTGFADFTHFADEGAANVVDEQQLHSLPPAAPP----------PQAAV 747
             ..|..:.|       |.:|                    |...|||.||          .:|.:
Human   499 -VFQPSVPA-------TKSG--------------------LLPPPPALPPRPCPSQSEQVSEAEL 535

  Fly   748 VPP-TRITLQQAQQRVSAFEV-YRKPQT--------PRGSQSPPQQPPPPA--PAVGLTTQTGQL 800
            :|. :|...|.|:...:..:| |.:|.:        |....:..|:|...|  ||
Human   536 LPQLSRAPSQAAESSPAKKDVLYSQPPSKPIRRKFRPENQATENQEPSTAASGPA---------- 590

  Fly   801 PSAESFEKRVTAISDSLRHVSFKQGQANTTEVLQRLREQNNSLLHLCNDLSDELLSVQTR---KE 862
             ||.:.:...|     ::..|.||.:|..| .:::.:|.|..|..|.::|..:|.:..||   :|
Human   591 -SAATMKPHPT-----VQKQSSKQKKAIQT-AIRKNKEANAVLARLNSELQQQLKAAGTRAHSQE 648

  Fly   863 EMR 865
            |.|
Human   649 EGR 651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Reps	NP_609487.2	EH	262..345	CDD:197477	45/82 (55%)
		EH	270..336	CDD:238009	34/65 (52%)
REPS2	XP_011543905.1	EFh	<75..121	CDD:298682	19/46 (41%)
		EH	275..370	CDD:197477	49/102 (48%)
		EH	286..352	CDD:238009	34/65 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	97	1.000	Domainoid score	I7269
eggNOG	1	0.900	-	-		E1_KOG1955
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	191	1.000	Inparanoid score	I3873
Isobase	1	0.950	-	0	Normalized mean entropy	S6242
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D116563at33208
OrthoFinder	1	1.000	-	-		FOG0002901
OrthoInspector	1	1.000	-	-		otm41203
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11216
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5227
SonicParanoid	1	1.000	-	-		X3315
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	11.000