Protein Alignment Reps and PAN1

DIOPT Version :10

• Sequence 1: NP_609487.2
• Gene: Reps / 34542
• FlyBaseID: FBgn0032341
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_012271.3
• Gene: PAN1 / 854822
• SGDID: S000001445
• Length: 1480
• Species: Saccharomyces cerevisiae
• Alignment Length: 1242
• Identity: 243/1242 - (19%)
• Similarity: 390/1242 - (31%)
• Gaps: 463/1242 - (37%)

  Fly    14 SELFQCCDVEKTGKVPMLKATELFRSADIANETVIEITGLAGIP-----STALHISRTQFYSCLK 73
            :.::..||..|.|::       ||....:|...:.::.....||     .|...:|  .|...:.
Yeast   309 ARIWTLCDTSKAGEL-------LFPEFALAMHLINDVLQGDTIPYELDSKTKNEVS--SFIDAIN 364

  Fly    74 LIAAHQ------AAMPLRQELILA----------------TFPLPL--------------PHFS- 101
            |..|:|      |......|.|.|                :|.:||              |..:
Yeast   365 LSIANQDSSANDAPKTPFDEFITAGVQNLQPQPTGYMPQTSFGIPLQSQITGGGVASALNPQSTG 429

  Fly   102 WKEAVTAPVAVENGLTALPPP----PPTDRRNSLRRNSQQEQLQDTSDVPSTDSEVEQNESVDDA 162
            :....|..:::..|...|.|.    .|...:.::..|:.|.  |.|..:|.|...:.|...:...
Yeast   430 FMAPTTFNMSMNTGTPGLNPQITGGAPASMQPNITGNALQP--QTTGMMPQTTGMMPQTTGMMPQ 492

  Fly   163 TGHGRGTDGCGVVSSSSRENVGRRRGGG------TGG-GS-------PEAWSTNS---------- 203
            |..|              .|:|.:..||      ||| ||       |.:....|
Yeast   493 TSFG--------------VNLGPQLTGGALQSQYTGGYGSVMPQQSGPASMPNLSFNQQGLQSQL 543

  Fly   204 ----DSPT----PTNSVAERP-WAQDTLWQGLLGDEHRQLLGTEEESSDRHSSDDDDNESELVTI 259
                ..||    |:|..|..| .||.|   |...:|............|..|.|
Yeast   544 TGLQPQPTGFLPPSNFSATMPLTAQKT---GFGNNEIYTKSNFNNNLIDNSSQD----------- 594

  Fly   260 YQITPEQREYYNKQFRTVQRDPHGLLSGQAARNFFEKSRIPVEELRHIWQLCDVTRDGALSLSEF 324
             :|:.|::..:.|.|.|......|||....|...|.||.:...:|..||.|||:...|.|:..||
Yeast   595 -KISTEEKSLFYKIFETFDTQNKGLLDSPTAVEIFRKSGLNRADLEQIWNLCDINNTGQLNKQEF 658

  Fly   325 TAAMHLVVLRRNNIPLPTSLPHCLHPNVLQAAASGSGQGVTSSSSAALPQEPP---EADLLHLND 386
            ...||||..:.|..|:|..||..|.|:..:...:...|..|..::.   :|.|   :.|.|...:
Yeast   659 ALGMHLVYGKLNGKPIPNVLPSSLIPSSTKLLDNLKNQLKTEPTTT---KEKPSFGKIDALSYKN 720

  Fly   387 DDED------------------------------DHTDNTIIAGNLSGSST----TSKPR-PNVP 416
            :|:|                              :|:.:|:...::|...|    |:||: ....
Yeast   721 NDDDVLPNYRNRRKVYSAKNEEQSSFSSPSAKSVNHSSSTLQTDDISVDKTVEKKTAKPKYAGFS 785

  Fly   417 SDKNIMNLSSISTSSQASNSSKREATPQNSLGK----------NRSISNSPNVEKPVSGTVSSTA 471
            .:.|:.|::|:      .|..|..:.|:|....          :..|:..||:...:| |:.:
Yeast   786 REINLKNIASL------ENEIKNISNPENCYDSSIPSDLTSRFDAIIAKLPNLFNEIS-TIDN-- 841

  Fly   472 SAVDSTNVSSQWTKFSESPTTSAVSVQSTTGAAP-----------------VVAAGAAASGASSP 519
               :.||...|..: .::|:       |..|:.|                 :.|..:|.:|.|:.
Yeast   842 ---EITNAKIQLYR-KKNPS-------SIIGSGPNGEITENDRKKAKSRALLRARMSALTGKSTE 895

  Fly   520 GLKPVLF-------DMKRSAQDVVSNPQILHPVPLRVTPIGTAIASSAESSN--EN--------- 566
            ....:..       ::||..|:...|.:|:..:...::.|..::.|:...||  .|
Yeast   896 SEDSLSMEDEQQSAEIKRIQQENGKNQEIIKDIRSSISDISASLKSTMTGSNMISNQEFERWEFG 960

  Fly   567 ---ESAVAQREDSPKAISSTTVNNQSSAVVPG---------ISGVAGSSHRDSSDLRAIQRPQAK 619
               |..|.:..|..|:.|:.:| .:||..||.         .|..:.|..:.:.:..|..:.|||
Yeast   961 IGLEDGVREFLDDLKSNSNKSV-TESSPFVPSSTPTPVDDRSSSPSYSQFKTAEERAAYLKEQAK 1024

  Fly   620 K----------------------LPAKNSALPP---------------PPQRE-------PS--I 638
            |                      :.::||...|               |.|.|       |:  :
Yeast  1025 KRMKEKLAKFDKNRRNVTQSSRSISSENSREQPQQIAGSSNLVEPRATPFQEEKYVEVAQPTQPV 1089

  Fly   639 GSTGPSESQEP-QAAYVASSLASKKEPPPLPPPRPHR---HARSSSLD-------------LNKF 686
            .||.|.:..:| |...........:...|:.|.:|.:   :|:..|.|             |.:.
Yeast  1090 QSTQPVQPTQPVQPTQPVQPTQPVQPTQPVQPTQPVQNVYNAKQESDDEDEDDEEKRLQEELKRL 1154

  Fly   687 KI------------------------------------GATGGAQQAEITAQASFDM-------- 707
            |:                                    |.....|.|.:...|:|..
Yeast  1155 KLKKKADKEKRLAALRKQIEDAQNESDEEETNGKDNFGGHVNVPQAAPVAPSAAFSQNSTNAPRS 1219

  Fly   708 ----------QTSTGFADFT-----HFADEGAA-------------------------------- 725
                      :.|||....|     :|.|..|:
Yeast  1220 VHAAVTPAAGKNSTGLPSTTMGHNPYFKDASASSTSTFDARAAEMQRRIQRGLDEDEDDGWSDED 1284

  Fly   726 ---------NVVDEQQL----HSLPP---AAPPPQAAVVPPTRITLQQA---QQRVSAFEVYRKP 771
                     |.|:|.::    |:..|   |||.|....|||. :.:.||   .::.|...:  .|
Yeast  1285 ESNNRVAVDNKVEEAKIGHPDHARAPPVTAAPLPSVTPVPPA-VPVPQANTSNEKSSPIPI--AP 1346

  Fly   772 QTPRGSQSPPQQPPPPAPAV-GLTTQTGQLPSAESFEKRVTAISDSLRHVSFKQG---------- 825
            ..|..:|.||....||.||| |.  |...:|||.:.   .||:..|........|
Yeast  1347 IPPSVTQEPPVPLAPPLPAVDGF--QEPPIPSAPAI---ATAVQKSGSSTPALAGGVLPPPPPLP 1406

  Fly   826 --QANTTEVLQRLREQNNSLLHLCN-------------DLSDELL----SVQTRKEEMRLKLEGL 871
              ||:|:|.:         :.|:.|             |..|::|    ||.|.:||     ||.
Yeast  1407 TQQASTSEPI---------IAHVDNYNGAEKGTGAYGSDSDDDVLSIPESVGTDEEE-----EGA 1457

  Fly   872 NASDSTG 878
            ....:.|
Yeast  1458 QPVSTAG 1464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Reps	NP_609487.2	EH	262..345	CDD:197477	29/82 (35%)
PAN1	NP_012271.3	DUF1720	144..243	CDD:369766
		EH	265..356	CDD:197477	10/53 (19%)
		DUF1720	<391..453	CDD:369766	8/61 (13%)
		DUF1720	459..553	CDD:369766	22/109 (20%)
		EH	595..688	CDD:197477	33/92 (36%)
		MAT1	<833..>934	CDD:461894	18/114 (16%)
		PAT1	982..>1127	CDD:401645	27/145 (19%)
		Amelogenin	<1064..1125	CDD:197891	11/60 (18%)