DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Reps and REPS1

DIOPT Version :9

Sequence 1:	NP_609487.2	Gene:	Reps / 34542	FlyBaseID:	FBgn0032341	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001273540.1	Gene:	REPS1 / 85021	HGNCID:	15578	Length:	796	Species:	Homo sapiens

Alignment Length:	963	Identity:	259/963 - (26%)
Similarity:	370/963 - (38%)	Gaps:	275/963 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VSLTEPETRFYSELFQCCDVEKTGKVPML-KATELFRSADIANETVIEITGLAGIPSTAL-HISR 65
            ::|::.|.::||:||..||:|.|.||.:. :..||||:|.:.|:.|::|..|.|  :|.| :..|
Human     4 LTLSDAEQKYYSDLFSYCDIESTKKVVVNGRVLELFRAAQLPNDVVLQIMELCG--ATRLGYFGR 66

  Fly    66 TQFYSCLKLIAAHQAAMPLRQELILATFPLPLPHF-------SWKEAVTAPVAVEN--GLTALPP 121
            :|||..|||:|..|:..|||.|.|.....||||.|       ..:.|.:.....||  ..:.:.|
Human    67 SQFYIALKLVAVAQSGFPLRVESINTVKDLPLPRFVASKNEQESRHAASYSSDSENQGSYSGVIP 131

  Fly   122 PPPTDRRNSLRRNSQQE---QLQDTSDVPSTDSEV---EQNESVDDAT--GHGRGTDGCGVVSSS 178
            |||  .|..:::.|...   |.:.::|.....|.|   :|:......|  .|.|...|    .:|
Human   132 PPP--GRGQVKKGSVSHDTVQPRTSADAQEPASPVVSPQQSPPTSPHTWRKHSRHPSG----GNS 190

  Fly   179 SR---------ENVGRRRGGGTGGGSPEAWSTNSDSPTPTN--SVAERPWAQDTLWQGLLGDEHR 232
            .|         ...|..:.|.:.|.:  .||.:|..|...|  |.|:.|.....|.......:.:
Human   191 ERPLAGPGPFWSPFGEAQSGSSAGDA--VWSGHSPPPPQENWVSFADTPPTSTLLTMHPASVQDQ 253

  Fly   233 QLLGTEEESSD-----RHSSDDDDNESELVTIYQITPEQREYYNKQFRTVQRDPHGLLSGQAARN 292
            ..:.|...::.     |.||..||.       ::||.|||:||..||:|:|.|.:|.:.|.||:.
Human   254 TTVRTVASATTAIEIRRQSSSYDDP-------WKITDEQRQYYVNQFKTIQPDLNGFIPGSAAKE 311

  Fly   293 FFEKSRIPVEELRHIWQLCDVTRDGALSLSEFTAAMHLVVLRRNNIPLPTSLPHCLHPNVLQAAA 357
            ||.||::|:.||.|||:|.|..:||||:|.||.||.||||.|:|...||..||..|.|.::..
Human   312 FFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVARKNGYDLPEKLPESLMPKLIDL-- 374

  Fly   358 SGSGQGVTSSSSAALPQEPPEADLLHLNDDDEDDHTDNTIIAGNLSGSSTTSKPRPNVPSDKNIM 422
                     ..||.:..:|.|.                     ..|||...:.|
Human   375 ---------EDSADVGDQPGEV---------------------GYSGSPAEAPP----------- 398

  Fly   423 NLSSISTSSQASNSSKREATPQNSLGKNRSISNSPNVEKPVSGTVSSTASAVDSTNVSSQWTKFS 487
                   |...|..|..:..|:    .|:|                           |.||..||
Human   399 -------SKSPSMPSLNQTWPE----LNQS---------------------------SEQWETFS 425

  Fly   488 ESPTTSAVSVQSTTGAAPVVAAGAAASGASSPGLKPVLFDMKRSAQDVVSNPQILHPVPLRVTPI 552
            |..::|....|..:..||           :.|                  :..|:||||:|:||
Human   426 ERSSSSQTLTQFDSNIAP-----------ADP------------------DTAIVHPVPIRMTP- 460

  Fly   553 GTAIASSAESSNENESAVAQREDSPKAISSTTVNNQSSAVVPGISGVAGSSHRDSSDLRAIQRPQ 617
                           |.:..:|...|...|...|..|..:|.. |.:...:..:||...|.....
Human   461 ---------------SKIHMQEMELKRTGSDHTNPTSPLLVKP-SDLLEENKINSSVKFASGNTV 509

  Fly   618 AKKLPAKNSALPPPPQ------REPSIGSTGPSESQEPQAAYVASSLASKKEPPPLPPPRPH-RH 675
            |....:.:|....|.|      |:.|...|.|..:                .||| |||||. .|
Human   510 ADGYSSSDSFTSDPEQIGSNVTRQRSHSGTSPDNT----------------APPP-PPPRPQPSH 557

  Fly   676 ARSSSLDLNK-FKIGATGGAQQAEITA------------QA------------SFDMQTST---- 711
            :||||||:|: |.:  |.|.|||.:.|            ||            .....|||
Human   558 SRSSSLDMNRTFTV--TTGQQQAGVVAHPPAVPPRPQPSQAPGPAVHRPVDADGLITHTSTSPQQ 620

  Fly   712 -----GFADFTHFADEGAANVVDEQ----QLHSLPPAAPPPQAAVVPPTRITLQQAQQRVSAFEV 767
                 .||||:.|....|:||.|||    :.|   |...|.:.|..|.:.:.:.:...:......
Human   621 IPEQPNFADFSQFEVFAASNVNDEQDDEAEKH---PEVLPAEKASDPASSLRVAKTDSKTEEKTA 682

  Fly   768 YRKPQTPRGSQSPPQQPPPPA-----------PAVGLTTQ-TGQL-------PS-AESFEKRVTA 812
            ...|.......:|...||.|.           |.|...|| ||.|       || ..|..|...|
Human   683 ASAPANVSKGTTPLAPPPKPVRRRLKSEDELRPEVDEHTQKTGVLAAVLASQPSIPRSVGKDKKA 747

  Fly   813 ISDSLRHVSFKQGQANTTEVLQRLREQNNSLLHLCNDLSDELLSVQTRKEEMR 865
            |..|:|    :..:.||  ||.||   |:.|.....|:.:|.:|::.:.|::|
Human   748 IQASIR----RNKETNT--VLARL---NSELQQQLKDVLEERISLEVQLEQLR 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Reps	NP_609487.2	EH	262..345	CDD:197477	45/82 (55%)
Reps	NP_609487.2	EH	270..336	CDD:238009	36/65 (55%)
REPS1	NP_001273540.1	EFh	14..81	CDD:298682	30/68 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	105..237		30/139 (22%)
		EH	278..369	CDD:197477	48/97 (49%)
		EH	289..355	CDD:238009	36/65 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	377..433		21/125 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	506..624		36/136 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	638..725		20/89 (22%)
		MCLC	<643..735	CDD:283562	20/94 (21%)
		Interaction with RALBP1. /evidence=ECO:0000250	652..796		38/152 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	97	1.000	Domainoid score	I7269
eggNOG	1	0.900	-	-		E1_KOG1955
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	191	1.000	Inparanoid score	I3873
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D116563at33208
OrthoFinder	1	1.000	-	-		FOG0002901
OrthoInspector	1	1.000	-	-		otm41203
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11216
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5227
SonicParanoid	1	1.000	-	-		X3315
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.960