DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Reps and pan1

DIOPT Version :9

Sequence 1:	NP_609487.2	Gene:	Reps / 34542	FlyBaseID:	FBgn0032341	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001342822.1	Gene:	pan1 / 5802955	PomBaseID:	SPAC25G10.09c	Length:	1794	Species:	Schizosaccharomyces pombe

Alignment Length:	852	Identity:	167/852 - (19%)
Similarity:	270/852 - (31%)	Gaps:	286/852 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 PTPTNSVAERPWAQDTLWQGLLGDEHRQLLGTE---EESSDRHSSDDDDN--ESELVTIYQITPE 265
            |..|..:|.:|......| |.:......|.|.|   ::......|...:|  :.:....:.|:.|
pombe   757 PQRTGGMAPQPTGMPGQW-GFINTPLSNLPGIEALGQQMMPNAPSGGLNNTFQQKKDIPWAISKE 820

  Fly   266 QREYYNKQFRTVQRDPHGLLSGQAARNFFEKSRIPVEELRHIWQLCDVTRDGALSLSEFTAAMHL 330
            ::..|::.|....::..|.|.|.|....|.:|::...||.|||.|||....|:|...||..|:||
pombe   821 EKRIYDQIFDAWDKERKGTLGGNAVLEIFGQSKLTRTELEHIWNLCDHGDKGSLDRDEFAVALHL 885

  Fly   331 VVLRRNNIPLPTSLPHCLHP--------------NVLQAAASG-------SGQGVTSSSSAALPQ 374
            :..:.|...:|..||..|.|              |:::...|.       :...:..:|....|.
pombe   886 IYRKLNGNEVPAVLPPELIPPSTRNFTESLNQVKNLIKNDTSNRKPFGAENQSKLKKNSFYDNPS 950

  Fly   375 EPPEAD--LLHLNDDDEDDHT-----------------------------------DNTIIAGNL 402
            |..|.|  |...||.|...:.                                   :.:::...|
pombe   951 ETTEKDATLYRHNDSDASAYVSSARRRDFKEEKIESAPPIINDIDSEIASLKKRIHEKSLVVNAL 1015

  Fly   403 SGSSTTSKPRPNVPSDKNIMNLSSI-------STSSQA--------------------------- 433
            ......:.|..:|.:|..|..:.|:       |||:::
pombe  1016 EDKKLAATPANDVQNDSLIYRIKSVQDEINRLSTSNKSPEVASMNVRLEELSTRVSKMLSDINEV 1080

  Fly   434 ----------------SNSSKREATPQNSLGKNRSISNS----------------------PNVE 460
                            :.:|..:.:|:.:..:||:||:.                      .|:|
pombe  1081 DHTIASLSLKLFQAEDTKNSYDQTSPEATQERNRTISSKLAEMEKQKNESKAALEQMKNYVTNIE 1145

  Fly   461 KPVSGTVSSTASAVD---STNVSSQWTKFSESPTTSAVSVQSTTGAAPVVAAGAAASGASSPGLK 522
            ..:...:..:|:..|   |.||..:             ||.......||.|..|..:      |.
pombe  1146 NNIRAKLLPSAANDDAWLSQNVVDE-------------SVTRVVKELPVPAPAAPQT------LN 1191

  Fly   523 PVLFDMKRSAQDVVSNPQILHPVPLRVTPIGTAIASSAESSNENESAVAQRE------------- 574
            |......:.::.:.||   .|...::.|....:.:|:.|.......|.|||.
pombe  1192 PPSVSTVQQSKPIESN---THTPEVKATSESPSASSNLEDRAARIKAEAQRRMNERLAALGIKPR 1253

  Fly   575 ----DSPKAISSTT-------------VNNQSSAVVPGISGVAGSSHRDSSDLRAIQRPQAKKLP 622
                .||..::|.|             ...|:|||...:..|:.|.....:.:..:|.||    |
pombe  1254 QKGTPSPAPVNSATSTPVAAPTAQQIQPGKQASAVSSNVPAVSASISTPPAVVPTVQHPQ----P 1314

  Fly   623 AKNSALPPPPQREPSIGSTGPSESQEPQAAYVASSLASKK-EPP--------------------- 665
            .|.  :|....::||..||..:.:..||.|.:.:..:... |||
pombe  1315 TKQ--IPTAAVKDPSTTSTSFNTAPIPQQAPLENQFSKMSLEPPVRPAVPTSPKPQIPDSSNVHA 1377

  Fly   666 PLPPPRP------HR--HARSSSLDLNKFKIGATGGAQQAEITAQAS-----FDMQTSTGFADFT 717
            |.||.:|      |.  :||.|:.:........:.|:..:.|..:.|     ....|:.| |...
pombe  1378 PPPPVQPMNAMPSHNAVNARPSAPERRDSFGSVSSGSNVSSIEDETSTMPLKASQPTNPG-APSN 1441

  Fly   718 HFADEGAANVVDEQQLHSLPPA----------APPPQAAVVPPTRITL---------------QQ 757
            |     |..||....:|::.|.          ||.|.:|..||..::.               ..
pombe  1442 H-----APQVVPPAPMHAVAPVQPKAPGMVTNAPAPSSAPAPPAPVSQLPPAVPNVPVPSMIPSV 1501

  Fly   758 AQQRVSAFEVYRKPQTPRGSQSPPQQ--------PPPPAPAVGLTTQTGQLPSAESFEKRVTAIS 814
            |||..|:.    .|.|...|..||.|        |.||||         |.|||.:...  ....
pombe  1502 AQQPPSSV----APATAPSSTLPPSQSSFAHVPSPAPPAP---------QHPSAAALSS--APAD 1551

  Fly   815 DSLRHVS 821
            :|:.|.|
pombe  1552 NSMPHRS 1558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Reps	NP_609487.2	EH	262..345	CDD:197477	27/82 (33%)
Reps	NP_609487.2	EH	270..336	CDD:238009	23/65 (35%)
pan1	NP_001342822.1	DUF1720	177..262	CDD:311924
		EH	276..368	CDD:197477
		DUF1720	422..508	CDD:311924
		Med15	473..>796	CDD:312941	9/39 (23%)
		EH	814..909	CDD:197477	31/94 (33%)
		SMC_N	<976..>1150	CDD:330553	17/173 (10%)
		Atrophin-1	<1180..1637	CDD:331285	90/415 (22%)
		WH2	1746..1772	CDD:308040
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11216
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5227
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.130