DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Reps and ucp8

DIOPT Version :9

Sequence 1:	NP_609487.2	Gene:	Reps / 34542	FlyBaseID:	FBgn0032341	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_595633.2	Gene:	ucp8 / 2540786	PomBaseID:	SPBC83.01	Length:	829	Species:	Schizosaccharomyces pombe

Alignment Length:	923	Identity:	187/923 - (20%)
Similarity:	301/923 - (32%)	Gaps:	283/923 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 ISRTQFYSCLKLIAAHQAAMPLRQELILATFPLPLPHFSWKEAVTAPVAVENGLTALPPPPPTDR 127
            :.|.|.|:|.:||:..|....| |||            .:.:|...|:        ||.....|
pombe    63 LDRNQVYACFRLISQAQRGATL-QEL------------DYNKAGDPPI--------LPKQAKDD- 105

  Fly   128 RNSLRRNSQQEQLQDTSDV--------PSTDSEVEQNESVDDATGH-GRGTDGCG--------VV 175
             :.::|:|     .:|:|.        |...||.|: |..::..|| .....||.        ::
pombe   106 -HHIKRSS-----SETADFTPFRIPINPDERSEYEK-EFRENLRGHEDSARPGCMPSSIAKPILL 163

  Fly   176 SSSSRENVGRRRGGGTGGGSPEAWSTNSDS-------------------------------PTPT 209
            .||....|           ..:.|:. :||                               ..|.
pombe   164 KSSLHYAV-----------LAQIWNL-ADSAHVGYLEMYQYVIARHLVAICKQYNLIHLPRSLPA 216

  Fly   210 NSV----AERPWAQDTLWQG-----LLGDE---HRQLLGTEEESSDRHSSDDDDNESELVTIYQ- 261
            :.:    :|.|.....:.||     |:..|   |:|.:.:.:.|.....|.|::.:|.:...|.
pombe   217 DVIESAKSETPAMNTNIEQGVTQPSLVNTEQLSHQQSISSTKSSKLDEISADNNAQSAVDNKYSS 281

  Fly   262 --------------ITPEQREYYNKQFRTVQRDPHGLLSGQAARNFFEKSRIPVEELRHIWQLCD 312
                          ||||.|..:.:.|..:..:..|.:.|..|..||..|.:..|||..||...|
pombe   282 PPQTIDPQANIKALITPEDRSNFYQLFSKIDNENKGYIVGGEAVPFFMASHLDSEELARIWDTVD 346

  Fly   313 VTRDGALSLSEFTAAMHLVVLRRNNIPLPTSLPH---CLHPNVLQAAASGSGQGVTSSSSAALPQ 374
            ....|.:...||..||.::.||.:...|.:.|.:   ...|.:.|...|..     :::|.|:|
pombe   347 TQDRGYIDKDEFAVAMEIIKLRLSGKSLASILAYDDNPTEPTMQQNLVSDD-----TNASTAVP- 405

  Fly   375 EPPEADLLHLNDDDED------DHTDNTIIAGNLSGSSTTSKPRPNVPSDKNIMNLSSISTSSQA 433
                  :...||:..:      |:..|:.:  ||..||.|:...|           :::|.....
pombe   406 ------VAFTNDNVSNVPLSVADNEPNSTL--NLLASSDTAAFEP-----------TAVSLHENP 451

  Fly   434 SNSSK--REATPQNSLGKNRSISNSPNVEKPVSGTVSSTASAVDSTNVSSQWTKFSESPTTSAVS 496
            |:|.:  :.|....|.....|..|..|.......|.|.:         |:|...|...|||.::
pombe   452 SSSLEDLQSAFQNTSFQDQVSTQNQANTADISQNTESGS---------STQGQMFGIPPTTQSI- 506

  Fly   497 VQSTTGAAPVVAAGAAASGASSPGLKPVLFDMKRSAQDVVSNPQILHPVPLRVTPIGTAIASSAE 561
                    |:..||       .||      .:..|..|:.....:....|.:.......|.:|..
pombe   507 --------PLKMAG-------FPG------GVNSSLTDIKEEEAVSENAPQQEERSFEQIKTSIH 550

  Fly   562 SSNENESAVAQREDSPKAIS-STTVNNQSSAVVPGISGVAGSSHRDSSDLRAIQRPQAKKLPAKN 625
            .:.||.||:.:.:..|...| :||:...:||                    |:...|..:.|.:.
pombe   551 IAPENISAIEESKSVPLPTSFATTIPGSTSA--------------------ALDDQQTTEAPFEE 595

  Fly   626 SALPPPPQREPS-------------IGSTGPS-ESQEPQAAYVASSLASKK--------EPPPLP 668
               |..|..||:             |.||... |:.:.....:...:..||        |...|.
pombe   596 ---PDEPAHEPTEEEQEEMRKLEEKIESTKYGLETIQTSGKTIKQRIEQKKTRLMILREELQELD 657

  Fly   669 PPRPHRHAR-SSSLDLNK---FKIGATGGAQQAEITAQASFDMQTSTGFADFTHFADEGAANVVD 729
            ..:.....: |.||..::   .:||:.|..::..:........:..:..||.......||.|
pombe   658 AIKEEAQKQISQSLIADQQLSTQIGSVGMGKKQAVKELRKLQAKIDSIIADSMSPMGTGAVN--- 719

  Fly   730 EQQLHSLPPAAPPPQAAVVPPTRITLQQAQQRVSAFEVYRKPQTPRGSQSPPQQPPPPAPAVGLT 794
                   .||. .||....|||                  ...||.....||  |||...::..:
pombe   720 -------SPAI-KPQVTPAPPT------------------PAPTPAVKHHPP--PPPVRSSISPS 756

  Fly   795 TQTGQLPSAESFEKRVTAISDSLRHVSFKQGQANTTEVLQRLREQNNSLLHLCNDLSDELLSVQT 859
            .....|..|.|        |..:.:||..:....:.|.:     ||:      |:|..||||:..
pombe   757 MPPAPLTHANS--------STPMNYVSQPESPPQSYESI-----QND------NELLQELLSMGF 802

  Fly   860 RKEEMRLKLEGLN 872
            .:|:..:.||..|
pombe   803 PREKAVIALEATN 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Reps	NP_609487.2	EH	262..345	CDD:197477	26/82 (32%)
Reps	NP_609487.2	EH	270..336	CDD:238009	20/65 (31%)
ucp8	NP_595633.2	EH	14..80	CDD:238009	6/16 (38%)
		EH	124..223	CDD:197477	16/111 (14%)
		EH	133..204	CDD:238009	12/83 (14%)
		EH	304..370	CDD:238009	20/65 (31%)
		EF-hand_7	305..362	CDD:290234	16/56 (29%)
		UBA	790..826	CDD:197551	10/32 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11216
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100