DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Reps and Reps2

DIOPT Version :9

Sequence 1:	NP_609487.2	Gene:	Reps / 34542	FlyBaseID:	FBgn0032341	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_839987.2	Gene:	Reps2 / 194590	MGIID:	2663511	Length:	648	Species:	Mus musculus

Alignment Length:	890	Identity:	209/890 - (23%)
Similarity:	322/890 - (36%)	Gaps:	292/890 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LTEPETRFYSELFQCCDVEKTG----------KVPMLKAT-------ELFRSADIANETVIEITG 52
            |::.|.:.|||||..|....:|          :|....||       :|||::.:..||:.:||.
Mouse    17 LSDSEQQCYSELFARCAGAASGGPGPGPPEATRVAPGTATAAAGPVADLFRASQLPPETLHQITE 81

  Fly    53 LAGIPSTALHISRTQFYSCLKLIAAHQAAMPLRQELILATFPLPLPHFSWKEAVTAPVAVENGLT 117
            |.|..... :...||||..||||||.||.:|:|.|.|..  .||||.|...:. ...:...|...
Mouse    82 LCGAKRVG-YFGPTQFYVALKLIAAAQAGLPVRTESIKC--ELPLPRFVMSKN-DGEIRFGNPAE 142

  Fly   118 ALPP----PPPTDRRNSLRRNSQQEQLQDT-----SDVPSTDSEVEQNESVDDATGHGRGTDGCG 173
            ...|    |..|..:||.:|...:::.|:|     |.:.|..|.....:.|..:.|:.:...|..
Mouse   143 LHGPKVQIPYLTTEKNSFKRMDNEDKQQETQSPTMSPLASPPSSPPHYQRVSLSHGYSKLRSGTE 207

  Fly   174 VVSSS--SRENVGRRRGGGTGGGSPEAWSTNSDSPTPTNSVAERPWAQDTLWQGLLGDEHRQLLG 236
            .:..:  .|:.:|:                      |....:|.|.|:....|..|    .:...
Mouse   208 QMHPAPYERQPIGQ----------------------PEGPSSEGPGAKPFRRQASL----IRSFS 246

  Fly   237 TEEESSDRHSSDDDDNESELVTIYQITPEQREYYNKQFRTVQRDPHGLLSGQAARNFFEKSRIPV 301
            .|.|..:.:|:..|:.       ::||.||||||..|||::|.||...:||..|:|||.||::.:
Mouse   247 VEREPQENNSNYPDEP-------WRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSI 304

  Fly   302 EELRHIWQLCDVTRDGALSLSEFTAAMHLVVLRRNNIPLPTSLPHCLHPNVLQAAASGSGQGVTS 366
            .||.:||:|.|...||||:||||.||.||:|.|:|..|||..||..|.|..||
Mouse   305 PELSYIWELSDADCDGALTLSEFCAAFHLIVARKNGYPLPEGLPPTLQPEYLQ------------ 357

  Fly   367 SSSAALPQEPPEADLLHLNDDDEDDHTDNTIIAGNLSGSSTTSKPRPNVPSDKNIMNLSSISTSS 431
               ||.|:...|..:.       |.:::                               |:..:.
Mouse   358 ---AAFPKSKWECAIF-------DSYSE-------------------------------SMPANQ 381

  Fly   432 QASNSSKREATPQNSLGKNRSISNSPNVEKPVSGTVSSTASAVDSTNVSSQWTKFSESPTTSAVS 496
            |:.:.::.|
Mouse   382 QSCDLNRME-------------------------------------------------------- 390

  Fly   497 VQSTTGAAPVVAAGAAASGASSPGLKPVLFDMKRSAQDVVSNPQILHPVPLRVTPIGTAIASSAE 561
                                            |.|.:||..     .|||.:  .:.||....|.
Mouse   391 --------------------------------KTSVKDVAD-----FPVPTQ--DVTTADDKQAL 416

  Fly   562 SSNENESAVAQREDSPKAISSTTVNNQSSAVVPGISGVAGSSHRDSSDLRAIQRPQAKKLPAKNS 626
            .|..|||.       ||.:|..|                 ::.:|.:.|:|  ||:::
Mouse   417 KSTVNESL-------PKDVSEDT-----------------ATSKDYNSLKA--RPRSR------- 448

  Fly   627 ALPPPPQREPSIGSTGPSESQEPQAAYVASSLASKKEPPPLPPPRPHR-HARSSSLDLNKFKIGA 690
                      |..||...|:.:            :.|.||.|||||.: |:|:|||||||..:.:
Mouse   449 ----------SYSSTSIEEAMK------------RGEDPPTPPPRPQKTHSRASSLDLNKVFLPS 491

  Fly   691 TGGAQQAEITAQASFDMQTSTGFADFTHFADEGAANVVDEQQLHSLPPAAPPPQAAVVPPTRITL 755
            ...|....:....:...:..           ...:..|.|..|||....| |.|||...||::..
Mouse   492 APAANSGLLPPPPALPPRPC-----------PTQSEPVSEADLHSQLNRA-PSQAAESSPTKMDA 544

  Fly   756 QQAQQRVSAFEVYRKPQTPRGSQSPPQQPPPPAPAVGLTTQTGQLPSAESFEKRVTAISDSLRHV 820
            ..||   ...:..|:...|....:..|:   ||.|||.......:....:.:|:.:....:::..
Mouse   545 PHAQ---PPSKPIRRKFRPENQTTESQE---PAAAVGGAVSAAMVKPHPTVQKQSSKQKKAIQTA 603

  Fly   821 SFKQGQANTTEVLQRLREQNNSLLHLCNDLSDELLSVQTRKEEMR 865
            ..|..:||.  ||.||   |:.|.....::..|.::::.:.|::|
Mouse   604 IRKNKEANA--VLARL---NSELQQQLKEVHQERIALENQLEQLR 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Reps	NP_609487.2	EH	262..345	CDD:197477	46/82 (56%)
Reps	NP_609487.2	EH	270..336	CDD:238009	35/65 (54%)
Reps2	NP_839987.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..107		31/90 (34%)
		EFh	<62..108	CDD:298682	19/46 (41%)
		EH	262..357	CDD:197477	50/101 (50%)
		EH	273..339	CDD:238009	35/65 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	277..353		40/75 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	367..444		25/235 (11%)
		Interaction with RALBP1. /evidence=ECO:0000250\|UniProtKB:Q8NFH8	502..648		35/165 (21%)
		Interaction with ASAP1. /evidence=ECO:0000250\|UniProtKB:Q8NFH8	549..648		21/103 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I7179
eggNOG	1	0.900	-	-		E1_KOG1955
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	191	1.000	Inparanoid score	I3863
Isobase	1	0.950	-	0	Normalized mean entropy	S6242
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D116563at33208
OrthoFinder	1	1.000	-	-		FOG0002901
OrthoInspector	1	1.000	-	-		otm43268
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11216
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5227
SonicParanoid	1	1.000	-	-		X3315
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	12.000