DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ge-1 and Edc4

DIOPT Version :10

Sequence 1:NP_609486.2 Gene:Ge-1 / 34541 FlyBaseID:FBgn0283682 Length:1354 Species:Drosophila melanogaster
Sequence 2:NP_001028240.3 Gene:Edc4 / 361399 RGDID:1562009 Length:1407 Species:Rattus norvegicus


Alignment Length:1525 Identity:382/1525 - (25%)
Similarity:646/1525 - (42%) Gaps:377/1525 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 IDAASGMSNSAEQDKPIAANG-----------------NAAEP----------QEIEVIHFQAQE 95
            :|..:|.||...|....|.||                 :.::|          ||.:||.....:
  Rat    22 LDRPAGGSNVESQRPSSAYNGDLNGLLVPDPLSSGDGNSTSKPGIRTMPPINLQEKQVICLSGDD 86

  Fly    96 KQCCRVIRSNKTKVLTSG----GVHTRGSSKVKLKNIVDYKWERKYYYPGHLVAVHRDGKHLAYA 156
            ...|..|.:.:.:::.|.    ....|||:|||::.:..|.||:|||| |:|:||  ....||||
  Rat    87 SSTCIGILAKEVEIVASSDSSISSKARGSNKVKIQPVAKYDWEQKYYY-GNLIAV--SNSFLAYA 148

  Fly   157 INVNNKATGMEGMVRVCNIATSMRALIKGMSGEVLDLQFAHTDCERILAVIDVSSLFVYKVDQIE 221
            |...|..:   .||||.:::||.|.|:||.:|.|.||.|||.:..::..:.:...|||:::..::
  Rat   149 IRAANNGS---AMVRVISVSTSERTLLKGFTGSVADLAFAHLNSPQLACLDEAGDLFVWRLALVK 210

  Fly   222 GNLLCNLVLKVEDPIANYVPEYDMVSWCPYV-------C-SSSATVPINDDDDENQLLIWSRSSQ 278
            |.:...:::.:..|....:..:..:.|||::       | .||.||.:..:|   :..:|     
  Rat   211 GKIQEEILVHIRQPEGTPLNHFRRIIWCPFIPEESEDCCEESSPTVALLHED---RAEVW----- 267

  Fly   279 FQCFQVKMIVSEHGRGKIQPAALESGYLKIEEDSLITC---AALSPDGTTVAAACADGLVRFYQI 340
                .:.|:.|.|....:..:.::.|::.::..|  ||   .|||||||.:|.|..||.|:|:||
  Rat   268 ----DLDMLRSSHSTWPVDVSQIKQGFIVVKGHS--TCLSEGALSPDGTVLATASHDGFVKFWQI 326

  Fly   341 YLFDVRNHRCLHEWKPHDGKKVCSLFFLDNINK-PVEESYWQHVITTSDANTEIKLWNCSLWKCL 404
            |:......|||||||||||:.:..|.|.||..| ..|..:|:.:||.:|.|.|:|:|....|.||
  Rat   327 YIEGQDEPRCLHEWKPHDGRPLSCLLFCDNHKKQDPEVPFWRFLITGADQNRELKMWCTVSWTCL 391

  Fly   405 QTI-------NVVASPSSLQPRNFIAGIDRSANYLVLSCLDSLAVYVMQIGSTGGADSENRSSDS 462
            |||       :.|:.|.||:     ..:|.||.||:||.:....:|||::          ..:..
  Rat   392 QTIRFSPDIFSSVSVPPSLK-----VCLDLSAEYLILSDVQRKVLYVMEL----------LQNQD 441

  Fly   463 EGEGCDTSKRIQNVAEFKLSSGILSFSIVNASMRRVKNSIESYYPIEEPDDFDDDSN-------S 520
            ||..|.:|     ::||.|:..:|||.|...|..|:::: |.....||.|....:|:       |
  Rat   442 EGRACFSS-----ISEFLLTHPVLSFGIQVVSRCRLRHT-EVLPAEEESDSLGTESSHGAGTLES 500

  Fly   521 TSALVLHMFVVQAKSLQECQIIYQP-----CVAEKTERSSLNSKRSQTPEDNLLIKEEPESPNSG 580
            .:.:::.:|.|..|:||:.||.:||     .||..:..::        .||....:..||..:.|
  Rat   501 AAGVLIKLFCVHTKALQDVQIRFQPQLNPDVVAPLSTHTA--------HEDFTFGESRPELGSEG 557

  Fly   581 TVGAVQLDALFAKSAKRASTGSSSAMVAVAAAAAAAPSAILQDATKEAAKSESPQLSSAYTQQVN 645
            ...|..              ||...:..:....|.|....|...||.                 .
  Rat   558 LASAPH--------------GSQPDLRRIVELPAPADFLSLSSETKP-----------------K 591

  Fly   646 LMTPDAFSASGTAAAAAVFVSTSTTTSIGTDSSTTTSGQDRS---IDSAVLQTIRMLATVTSKTS 707
            ||||||| .:.||:...:..|.|:::|..:.||:::|....|   ..|||..:..|..::.|:..
  Rat   592 LMTPDAF-MTPTASLQQISASPSSSSSSSSSSSSSSSSSSSSSLTAVSAVSSSSAMDPSLPSRPP 655

  Fly   708 ENPNAEVLLNLMNNTLIEDREQQKLKEKLDARKKFI-----------AIDRNPERNVAENLASGS 761
            |.......|.|..:..|..      ...|.|..:.:           .|.:.|.:     ::||:
  Rat   656 EELTLSPKLQLDGSLTISS------SSSLQASPRSLLPGLLPGPADKLIPKGPGQ-----VSSGT 709

  Fly   762 SSPSREVQEIMATQDDADAYEAELENLDDDDDDEEEELANSSPLPEAVDGTW--PIVKLSSHSAE 824
            |:.|.::||:                         |.|.    ||:|.....  |.|..|:.:|.
  Rat   710 SALSLDLQEV-------------------------EPLG----LPQASPSRTRSPDVISSASTAL 745

  Fly   825 LQNAAQIMSQAVQNTNNGNVPPTLGGGHNNNTSVGSNSNNNTATTLSTSNTSSSNNAGGTCVDSS 889
            .|:..:|.|:|:......:||.            |....::.|:..|..:..|.....|..:.|.
  Rat   746 SQDIPEIASEALSRGFGSSVPE------------GLIEPDSMASAASALHLLSPRPRQGPELSSQ 798

  Fly   890 -------GTGELNAKMELLIDLVKAQSKQINKLENEV--------------------NKLQKQQE 927
                   |.|:.::...|   |..|.::::...:::|                    |.||::.:
  Rat   799 LGLDGGPGDGDRHSTPSL---LEAALTQEVATSDSQVWPTAPDITRETCSTLTESPRNGLQEKHK 860

  Fly   928 AAA---------ALHSKQDTSLE------------------------------------------ 941
            :.|         ..|..||||.|                                          
  Rat   861 SLAFHRPPYHLLQQHDSQDTSAEQSDHDDEVASLASASGGFGSKIPTPRLPAKDWKTKGSPRTSP 925

  Fly   942 ---------------------------PKNLSQLAYKIEMQLSKL-------------------- 959
                                       |::...|.::.:.:|::|                    
  Rat   926 KLKRKSKKDDGDSAVGSRLTEHQVVEPPEDWPALIWQQQRELAELWHNQEELLQRLCAQLEGLQS 990

  Fly   960 -----MEQYLKRYENEHKKKLTEFLAARESQNRELRDSVLQVLNQYVMNHFTDIIGNVLNMELQR 1019
                 :|:.|:....:.:::|...||..:.:..:|::.:.|.|:|.:.:.....:...:..|:::
  Rat   991 TVTDHVERALETRHEQEQRRLERALAEGQQRGGQLQEQLTQQLSQALSSAVAGRLERSIRDEIKK 1055

  Fly  1020 QLLPRVNANMDQLQAQMQVEIVQKLSVFDKTVKENIAQVCKSKQFLDTFGKSVLIGVQTSLQTAF 1084
            .:.|.|:.:::.:..|:...:..||:..:.::||||:::.|||...|...::....:|..:|.|:
  Rat  1056 TVPPCVSRSLEPVAGQLSNSVATKLTAVEGSMKENISKLLKSKNLTDAIARAAADTLQGPMQAAY 1120

  Fly  1085 IESMSSTLIPAYEKSSQNMFKQLHDAFSVGIKDFMVQFNTYLQHMPQPQAGSGNTEEINNKLSML 1149
            .|:..|.::||:|||.|.||:|::|:|.:|.::::.|.::   ||...:|......|  ..|:.|
  Rat  1121 REAFQSVVLPAFEKSCQAMFQQINDSFRLGTQEYLQQLDS---HMKSRKAREQEARE--PVLAQL 1180

  Fly  1150 KQLVESSLHKHRTELTDAML------ETQRE----VKSLEILLARQVQETIRAELRKHMEAQNV- 1203
            :.||  |..::.||...|.:      |.|.:    |.||:..:..|||..::.|:...::.|.. 
  Rat  1181 RGLV--STLQNATEQMAATVSSSVRAEVQHQLHVAVGSLQESILAQVQRIVKGEVSVALKEQQAT 1243

  Fly  1204 -------AMRSQAATPAPPYDL-----RDSIKQLLMAGQINKAFHQALLANDLGLVEFTLRHTDS 1256
                   ||||.|.||.|...|     :..|.|||..|.:|:||.|||.|.||.||.:.....|.
  Rat  1244 VTSSIMQAMRSAAGTPVPSAHLDCQAQQAHILQLLQQGHLNQAFQQALTAADLNLVLYVCETVDP 1308

  Fly  1257 NQAFAPEGCRLEQKVLLSLIQQISADMTNHNELKQRYLNEALLAINMADPITREHAPKVLTELYR 1321
            .|.|....|.|.|.||||||||:::|:...::||..||.||::.::.:|||||:|...|:.::.:
  Rat  1309 AQVFGQPPCPLSQPVLLSLIQQLASDLGTRSDLKLSYLEEAVMHLDHSDPITRDHMGSVMAQVRQ 1373

  Fly  1322 NCQQFIKNSPKNSQFSNVR---LLMKAIIT 1348
            ...||::..|.||.....|   |::..::|
  Rat  1374 KLFQFLQADPHNSLGKAARRLSLMLHGLVT 1403

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ge-1NP_609486.2 Ge1_WD40 119..452 CDD:465162 122/351 (35%)
WD40 repeat 144..185 CDD:293791 16/40 (40%)
WD40 repeat 191..230 CDD:293791 9/38 (24%)
WD40 repeat 235..307 CDD:293791 15/79 (19%)
WD40 repeat 315..355 CDD:293791 23/42 (55%)
WD40 repeat 362..408 CDD:293791 20/53 (38%)
Mplasa_alph_rch 893..>1063 CDD:275316 39/292 (13%)
Edc4NP_001028240.3 Ge1_WD40 114..440 CDD:465162 122/360 (34%)
WD 1 174..214 12/39 (31%)
WD 2 230..277 12/58 (21%)
WD 3 295..334 19/40 (48%)
WD40 repeat 304..343 CDD:293791 23/38 (61%)
WD 4 342..393 21/50 (42%)
WD40 repeat 349..396 CDD:293791 20/46 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 547..566 5/32 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 604..632 6/27 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 673..745 18/111 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 787..817 5/32 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 875..951 6/75 (8%)

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