Protein Alignment Ge-1 and EDC4

DIOPT Version :10

• Sequence 1: NP_609486.2
• Gene: Ge-1 / 34541
• FlyBaseID: FBgn0283682
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_001414274.1
• Gene: EDC4 / 23644
• HGNCID: 17157
• Length: 1437
• Species: Homo sapiens
• Alignment Length: 1555
• Identity: 392/1555 - (25%)
• Similarity: 656/1555 - (42%)
• Gaps: 383/1555 - (24%)

  Fly    27 PSVHRSPRCGKASTAYH--------PPPADACISITASAIDAASGMSNSAEQDKPIAANGNAAEP 83
            ||. .|||   .|:||:        |.|             ..||.|.||.:      .|....|
Human    29 PSA-ESPR---PSSAYNGDLNGLLVPDP-------------LCSGDSTSANK------TGLRTMP 70

  Fly    84 ----QEIEVIHFQAQEKQCCRVIRSNKTKVLTSG----GVHTRGSSKVKLKNIVDYKWERKYYYP 140
                ||.:||.....:...|..|.:.:.:::.|.    ....|||:|||::.:..|.||:||||
Human    71 PINLQEKQVICLSGDDSSTCIGILAKEVEIVASSDSSISSKARGSNKVKIQPVAKYDWEQKYYY- 134

  Fly   141 GHLVAVHRDGKHLAYAINVNNKATGMEGMVRVCNIATSMRALIKGMSGEVLDLQFAHTDCERILA 205
            |:|:||  ....|||||...|..:   .||||.:::||.|.|:||.:|.|.||.|||.:..::..
Human   135 GNLIAV--SNSFLAYAIRAANNGS---AMVRVISVSTSERTLLKGFTGSVADLAFAHLNSPQLAC 194

  Fly   206 VIDVSSLFVYKVDQIEGNLLCNLVLKVEDPIANYVPEYDMVSWCPYV-------C-SSSATVPIN 262
            :.:..:|||:::..:.|.:...:::.:..|....:..:..:.|||::       | .||.||.:.
Human   195 LDEAGNLFVWRLALVNGKIQEEILVHIRQPEGTPLNHFRRIIWCPFIPEESEDCCEESSPTVALL 259

  Fly   263 DDDDENQLLIWSRSSQFQCFQVKMIVSEHGRGKIQPAALESGYLKIEEDSLITC---AALSPDGT 324
            .:|   :..:|         .:.|:.|.|....:..:.::.|::.::..|  ||   .|||||||
Human   260 HED---RAEVW---------DLDMLRSSHSTWPVDVSQIKQGFIVVKGHS--TCLSEGALSPDGT 310

  Fly   325 TVAAACADGLVRFYQIYLFDVRNHRCLHEWKPHDGKKVCSLFFLDNINK-PVEESYWQHVITTSD 388
            .:|.|..||.|:|:|||:......|||||||||||:.:..|.|.||..| ..:..:|:.:||.:|
Human   311 VLATASHDGYVKFWQIYIEGQDEPRCLHEWKPHDGRPLSCLLFCDNHKKQDPDVPFWRFLITGAD 375

  Fly   389 ANTEIKLWNCSLWKCLQTI-------NVVASPSSLQPRNFIAGIDRSANYLVLSCLDSLAVYVMQ 446
            .|.|:|:|....|.|||||       :.|:.|.||:     ..:|.||.||:||.:....:|||:
Human   376 QNRELKMWCTVSWTCLQTIRFSPDIFSSVSVPPSLK-----VCLDLSAEYLILSDVQRKVLYVME 435

  Fly   447 IGSTGGADSENRSSDSEGEGCDTSKRIQNVAEFKLSSGILSFSIVNASMRRVKNSIESYYPIEEP 511
            :          ..:..||..|.:|     ::||.|:..:|||.|...|..|::::  ...|.||.
Human   436 L----------LQNQEEGHACFSS-----ISEFLLTHPVLSFGIQVVSRCRLRHT--EVLPAEEE 483

  Fly   512 DD-FDDDS-------NSTSALVLHMFVVQAKSLQECQIIYQPCVAEKTERSSLNS------KRSQ 562
            :| ...|.       .|.:.:::.:|.|..|:||:.||.:||         .||.      ....
Human   484 NDSLGADGTHGAGAMESAAGVLIKLFCVHTKALQDVQIRFQP---------QLNPDVVAPLPTHT 539

  Fly   563 TPEDNLLIKEEPESPNSGTVGAVQLDALFAKSAKRASTGSSSAMVAVAAAAAAAPSAILQDATKE 627
            ..||....:..||..:.| :|:             |:.||...:..:....|.|....|...||.
Human   540 AHEDFTFGESRPELGSEG-LGS-------------AAHGSQPDLRRIVELPAPADFLSLSSETKP 590

  Fly   628 AAKSESPQLSSAYTQQVNLMTPDAFSASGTAAAAAVFVSTSTTTSIGTDSSTTTSGQDRSIDSAV 692
                             .||||||| .:.:|:...:..|.|:::| |:.||:::|....:..||:
Human   591 -----------------KLMTPDAF-MTPSASLQQITASPSSSSS-GSSSSSSSSSSSLTAVSAM 636

  Fly   693 LQTIRMLATVTSKTSE---NPNAEV--LLNLMNNTLIEDREQQKLKEKLDARKKFIAIDRNPERN 752
            ..|..:..::|....|   :|..::  .|.:.::..::...:..|...|.|     ..|:...:.
Human   637 SSTSAVDPSLTRPPEELTLSPKLQLDGSLTMSSSGSLQASPRGLLPGLLPA-----PADKLTPKG 696

  Fly   753 VAENLASGSSSPSREVQEIMATQDDADAYEAELENLDDDDDDEEEELANSSPLPEAVDGTW--PI 815
            ..: :.:.:|:.|.|:||:                         |.|.    ||:|.....  |.
Human   697 PGQ-VPTATSALSLELQEV-------------------------EPLG----LPQASPSRTRSPD 731

  Fly   816 VKLSSHSAELQNAAQIMSQAVQNTNNGNVP-------------------------PTLGGGHNNN 855
            |..|:.:|..|:..:|.|:|:......:.|                         |.||.....:
Human   732 VISSASTALSQDIPEIASEALSRGFGSSAPEGLEPDSMASAASALHLLSPRPRPGPELGPQLGLD 796

  Fly   856 TSVGSNSNNNTATTLSTSNTSSSNNAGG------------TC---VDSSGTGELNAKMELLI--- 902
            ...|....:||.:.|..:.|..::....            ||   .:|...| |..|.:.|.
Human   797 GGPGDGDRHNTPSLLEAALTQEASTPDSQVWPTAPDITRETCSTLAESPRNG-LQEKHKSLAFHR 860

  Fly   903 ---------DLVKAQSKQINKLENEVNKL------------------------------------ 922
                     |...|.::|.:. ::||..|
Human   861 PPYHLLQQRDSQDASAEQSDH-DDEVASLASASGGFGTKVPAPRLPAKDWKTKGSPRTSPKLKRK 924

  Fly   923 QKQQEAAAALHSK--QDTSLEP------------KNLSQLAYKIEMQLSKL-------------- 959
            .|:.:..||:.|:  :....||            :.|::|.:..|..|.:|
Human   925 SKKDDGDAAMGSRLTEHQVAEPPEDWPALIWQQQRELAELRHSQEELLQRLCTQLEGLQSTVTGH 989

  Fly   960 MEQYLK-RYENEH-----------------------------------KKKLTEFLAARESQNRE 988
            :|:.|: |:|.|.                                   :::|...||..:.:..:
Human   990 VERALETRHEQERILETGSTTWHRDGGSILGLGRSTRPAPGPFLSYGAERRLERALAEGQQRGGQ 1054

  Fly   989 LRDSVLQVLNQYVMNHFTDIIGNVLNMELQRQLLPRVNANMDQLQAQMQVEIVQKLSVFDKTVKE 1053
            |::.:.|.|:|.:.:.....:...:..|:::.:.|.|:.:::.:..|:...:..||:..:.::||
Human  1055 LQEQLTQQLSQALSSAVAGRLERSIRDEIKKTVPPCVSRSLEPMAGQLSNSVATKLTAVEGSMKE 1119

  Fly  1054 NIAQVCKSKQFLDTFGKSVLIGVQTSLQTAFIESMSSTLIPAYEKSSQNMFKQLHDAFSVGIKDF 1118
            ||:::.|||...|...::....:|..:|.|:.|:..|.::||:|||.|.||:|::|:|.:|.:::
Human  1120 NISKLLKSKNLTDAIARAAADTLQGPMQAAYREAFQSVVLPAFEKSCQAMFQQINDSFRLGTQEY 1184

  Fly  1119 MVQFNTYLQHMPQPQAGSGNTEEINNKLSMLKQLVESSLHKHRTELT-----DAMLETQRE---- 1174
            :.|..:   ||...:|......|  ..|:.|:.|| |:|.....::.     ....|.|.:
Human  1185 LQQLES---HMKSRKAREQEARE--PVLAQLRGLV-STLQSATEQMAATVAGSVRAEVQHQLHVA 1243

  Fly  1175 VKSLEILLARQVQETIRAELRKHMEAQNV--------AMRSQAATPAPPYDL-----RDSIKQLL 1226
            |.||:..:..|||..::.|:...::.|..        ||||.|.||.|...|     :..|.|||
Human  1244 VGSLQESILAQVQRIVKGEVSVALKEQQAAVTSSIMQAMRSAAGTPVPSAHLDCQAQQAHILQLL 1308

  Fly  1227 MAGQINKAFHQALLANDLGLVEFTLRHTDSNQAFAPEGCRLEQKVLLSLIQQISADMTNHNELKQ 1291
            ..|.:|:||.|||.|.||.||.:.....|..|.|....|.|.|.||||||||:::|:....:||.
Human  1309 QQGHLNQAFQQALTAADLNLVLYVCETVDPAQVFGQPPCPLSQPVLLSLIQQLASDLGTRTDLKL 1373

  Fly  1292 RYLNEALLAINMADPITREHAPKVLTELYRNCQQFIKNSPKNSQFSNVR---LLMKAIIT 1348
            .||.||::.::.:|||||:|...|:.::.:...||::..|.||.....|   |::..::|
Human  1374 SYLEEAVMHLDHSDPITRDHMGSVMAQVRQKLFQFLQAEPHNSLGKAARRLSLMLHGLVT 1433

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ge-1	NP_609486.2	Ge1_WD40	119..452	CDD:465162	121/351 (34%)
		WD40 repeat	144..185	CDD:293791	16/40 (40%)
		WD40 repeat	191..230	CDD:293791	9/38 (24%)
		WD40 repeat	235..307	CDD:293791	15/79 (19%)
		WD40 repeat	315..355	CDD:293791	23/42 (55%)
		WD40 repeat	362..408	CDD:293791	19/53 (36%)
		Mplasa_alph_rch	893..>1063	CDD:275316	44/281 (16%)
EDC4	NP_001414274.1	Ge1_WD40	114..441	CDD:465162	121/361 (34%)
		WD40 repeat	180..219	CDD:293791	9/38 (24%)
		WD40 repeat	232..288	CDD:293791	13/67 (19%)
		WD40 repeat	300..341	CDD:293791	21/40 (53%)
		WD40 repeat	348..393	CDD:293791	16/44 (36%)
		PHA03247	<525..982	CDD:223021	94/535 (18%)