DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr59 and MTC5

DIOPT Version :9

Sequence 1:	NP_609485.4	Gene:	Wdr59 / 34540	FlyBaseID:	FBgn0032339	Length:	969	Species:	Drosophila melanogaster
Sequence 2:	NP_010413.3	Gene:	MTC5 / 851706	SGDID:	S000002535	Length:	1148	Species:	Saccharomyces cerevisiae

Alignment Length:	1213	Identity:	259/1213 - (21%)
Similarity:	436/1213 - (35%)	Gaps:	385/1213 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 DSQATAMSVDYSGQWVLLAGRGHLALQRLGQDDGSLRRHERQSKYEVSVAEFAICPSRKEYCAIA 104
            |....|:|::.||:.::||.|..|.:..|.......|.....:.::|:..:::..|: |.|..::
Yeast    24 DGGFNAVSINPSGRDIVLASRQGLYIIDLDDPFTPPRWLHHITPWQVADVQWSPHPA-KPYWIVS 87

  Fly   105 TSQHIDIVRWGTAEPH---YEMSLRGHTRTVTDIDWHGKDPNLLVSCSIDTFSHIWDLREPRKPA 166
            ||....|: |..|:..   .|..|.||:|.:|||:::.:.|::|.:||:||:.|.||:|.|.:|.
Yeast    88 TSNQKAII-WNLAKSSSNAIEFVLHGHSRAITDINFNPQHPDVLATCSVDTYVHAWDMRSPHRPF 151

  Fly   167 LSLNAVCMSGATQVGFNRVSGNLLAAAHDGDLRIWDIRKGSCPTHYITAHLNRVHGINWSHKRET 231
            .|.:: ..|.|:||.:|....|:||::|..|:.:||:||||.|...:..|::.|:.|:::..:.:
Yeast   152 YSTSS-WRSAASQVKWNYKDPNVLASSHGNDIFVWDLRKGSTPLCSLKGHVSSVNSIDFNRFKYS 215

  Fly   232 CLATASQDGTVKYFDVC-NPRRAEKIITTMSPVWRARYTPIGNGLVSIVVPHLGRGENSLLLWS- 294
            .:.::|.|||||::|.. :...:::.:||..|:||.||.|.|.|.  .::|.:| |.|::.|.:
Yeast   216 EIMSSSNDGTVKFWDYSKSTTESKRTVTTNFPIWRGRYLPFGEGY--CIMPMVG-GNNAVYLINL 277

  Fly   295 -------NSKQT--DPICSFVGHTDVILDFAWRPNRE-----SSNEIELVTWSRDRTLRVWKIDD 345
                   .:|:|  .||.:|.||:|.::||.||....     ...|.:|||||:|..|::|.|.|
Yeast   278 CDDDDSEQNKKTKLQPIYAFKGHSDRVIDFLWRSRHTCDGDYDDREFQLVTWSKDCDLKLWPISD 342

  Fly   346 NML-KLCEPSAEEIESRFEPDLSELRVPTPP---------EFLHPRSILVAASLPISTGDGACNT 400
            ::. |:.....:.:|.:. ||.........|         ||...|...|..|
Yeast   343 SIYGKVNFDRGKRLEEKL-PDYDYCSYNKEPENRENVQKNEFRRLRENFVTTS------------ 394

  Fly   401 LPMARSPSFGGGYYRREEPHIA-------RSLTDQPTC-------SLHHEFSLLNTNMPHVEVDT 451
                       |..:.:..||.       .|.|.|...       :|..|.|.:....|.|..:.
Yeast   395 -----------GLKKNKTNHITWLSGIRMNSATSQEDLFNETKIQNLGEEVSAIGHKFPKVVFEK 448

  Fly   452 LDAIKRYACFKICAGGHT--------VILQVTFTTSYPSPSAPPDFQLCQGTTLSSEVSGVLLKV 508
            :....|..|..:......        :.:.:.|..:||:...||.|.:.:.:.|:......:|..
Yeast   449 ISVSTRELCLTLNGPWSEENPDDYIFLRISINFPLNYPNKGDPPKFTIEENSNLTMSKRQEILSN 513

  Fly   509 LRCNALQRVKKSRTCLEQCLRALVAAMKKKVAAVGGADRSQLLLQSPRLE-------GALSSTLH 566
            |.....:....:..|||.|:|.::.   :||:.....:..:.||.....:       .:|.|:..
Yeast   514 LATIGQKYTDSNLYCLEPCIRFVLG---EKVSLEDIEEGQEPLLNFDIADHIDFEELSSLDSSYS 575

  Fly   567 DACIP-----------------YPRTS--GVHF------------NAIGMLTT-----FAQPVNN 595
            |:..|                 :|.||  |:.|            |..|...|     |....|.
Yeast   576 DSQNPENLSSQSDIESYKEALVFPDTSNQGLDFGRNLALDTTPVPNGCGSCWTATGELFCFFANE 640

  Fly   596 KRLTLRQHTALTPRTFSSINGSGLLGNVMATAQREANAS---FYLQERMISGKPG---------- 647
            |:...:|:.                  ::..:|:||...   |.::.:::..|..
Yeast   641 KKPEKKQNA------------------IIKLSQKEAGVEKHPFKIEPQVLYDKEVDSSVITAADE 687

  Fly   648 -KQRAIRQM---------NGSPVVHVYDTSS------------------------LLHISRRMAR 678
             |.|..|.:         ||....:..|.:|                        .:.|.|...:
Yeast   688 LKARPKRYVDTLGLGGGTNGDSRTYFDDETSSDDSFDSVADDWDDILRNDIIVRTKIPILRGNFK 752

  Fly   679 EFS---LDKCNIAETCRKN----------------GEICRQHGRLDLVPVW------LLAELIAT 718
            .||   .:.....|:.:||                .|:..::..:|..|..      |:||....
Yeast   753 AFSSVHSESGKTVESTKKNKNLVISKNFSSLLSDRKELALEYLFMDATPEGFARNNALVAEKFDL 817

  Fly   719 PQIPH--ETLNDLLFYK---DPFK----------KSLLESLIMHYAISGDIQTAVLLACLF---- 764
            .:|.|  :.|:|:|..:   ||:.          |..::..|:::....::|...:|.|:.
Yeast   818 DEISHCWQILSDMLIDQSDYDPYTTIWNNHPMGIKWFIKEAIVYFERQQNLQMLAMLCCVILSAR 882

  Fly   765 -DKCPTG--GGAI--MEKTV--------------------------RLPPQL------------- 785
             .|.|..  |..:  ||.|:                          .:.|..
Yeast   883 RKKIPARYYGQELENMEGTIVFNDNESQNTSFWKGSDAFSTRSRSSTVTPNFYGNHLRGKNIHGG 947

  Fly   786 -NSQI-----------------------------------SPYHTVLPLDVK----SSSSSNTWQ 810
             ||.|                                   ||:|:.:| |:|    .......::
Yeast   948 DNSSIRSDDHHARLRTHNTLNGSSKFTEPAQKQGSRAISSSPFHSRMP-DIKVELLHDDIIEAYE 1011

  Fly   811 QLKQLRSNSWSDSLDLEIKQIQSDAYACSLIRRTKMPLFDQFKRAYAEILFGWQLLSKRALILK- 874
            |         .|.|.||:..|               |.|..:...|:::||.|.|..:|..|||
Yeast  1012 Q---------EDLLHLEVSDI---------------PKFQTYIYQYSKLLFRWGLPLERVKILKV 1052

  Fly   875 --------HTQNTPP------PVQGV--------EFVTECRKCAKPKRTPKCEPCKRPVLFCVLC 917
                    .:|..||      |..||        ||..|                |.....|..|
Yeast  1053 STDFRSSYSSQGIPPNNNKKSPYNGVLTHWIENNEFGEE----------------KFLARNCNYC 1101

  Fly   918 RLPVKGAANACLACGHGGHIDHMMQWFEKHNVCAT-CGCKCLE 959
            .|.|..::..|..|.|..|......|:|..:.|.: |||.|.|
Yeast  1102 DLRVTRSSFICGNCQHVLHSSCARIWWEIGDECPSGCGCNCPE 1144

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr59	NP_609485.4	WD40	<92..343	CDD:225201	92/269 (34%)
		WD40 repeat	132..170	CDD:293791	16/37 (43%)
		WD40 repeat	178..213	CDD:293791	15/34 (44%)
		WD40 repeat	220..259	CDD:293791	9/39 (23%)
		WD40 repeat	263..306	CDD:293791	16/52 (31%)
		WD40 repeat	312..341	CDD:293791	12/33 (36%)
		mRING-H2-C3H3C2_WDR59	912..957	CDD:319606	14/45 (31%)
		modified RING-H2 finger (C3H3C2-type)	914..953	CDD:319606	11/39 (28%)
MTC5	NP_010413.3	WD40 repeat	29..63	CDD:293791	10/33 (30%)
		WD40	<70..230	CDD:421866	56/162 (35%)
		WD40 repeat	71..112	CDD:293791	10/42 (24%)
		WD40 repeat	117..154	CDD:293791	15/36 (42%)
		PLN00181	<143..346	CDD:177776	70/206 (34%)
		WD40 repeat	162..198	CDD:293791	15/35 (43%)
		WD40 repeat	204..245	CDD:293791	10/40 (25%)
		WD40 repeat	248..298	CDD:293791	16/52 (31%)
		WD40 repeat	304..338	CDD:293791	12/33 (36%)
		RWD	433..543	CDD:214735	22/112 (20%)
		Zn_ribbon_17	1092..1147	CDD:375001	17/53 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0309
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38685
Inparanoid	1	1.050	215	1.000	Inparanoid score	I794
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005787
OrthoInspector	1	1.000	-	-		oto99832
orthoMCL	1	0.900	-	-		OOG6_104242
Panther	1	1.100	-	-	LDO	PTHR46170
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1668
SonicParanoid	1	1.000	-	-		X4177
TreeFam	1	0.960	-	-
	12	11.850