DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wdr59 and RAD28

DIOPT Version :9

Sequence 1:	NP_609485.4	Gene:	Wdr59 / 34540	FlyBaseID:	FBgn0032339	Length:	969	Species:	Drosophila melanogaster
Sequence 2:	NP_010313.3	Gene:	RAD28 / 851594	SGDID:	S000002437	Length:	506	Species:	Saccharomyces cerevisiae

Alignment Length:	358	Identity:	78/358 - (21%)
Similarity:	124/358 - (34%)	Gaps:	78/358 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ETLRPGERGTAGGPGAGAPEQTYIVRQSN--KYYEHRDSQATAMSVDYSGQWVLLAGRGHLALQR 67
            |:|...:.|          ||..|.::.|  |...|:.....|..:.|..:...:.....:.|..
Yeast    88 ESLHRNDEG----------EQELINKRLNYIKRQPHQSDDEPAQIMGYKNKRTRINDNNTMRLVH 142

  Fly    68 LGQDDGSLRRHERQSKYEVSVAEFAICPSRKEYCAIATSQHIDIVRWGTAEPHYEMSLRGHTRTV 132
            ..|...:..|..|||...|.|....|  |.|....|..|:.:       :|...|.|:..|...:
Yeast   143 SFQTQRNKYRMYRQSSAAVPVQRSHI--SNKTDSPIGFSETL-------SETDSEASISHHKYGI 198

  Fly   133 TDIDWHGKDPNLLVSCSIDTFSHIWDLREPRKPAL-SLNAVCMSGATQVGF--NRVSGN------ 188
            |.:.|:..|..:..:.|.|....|||..  |..|: .:|         :|:  |::..|
Yeast   199 TTLKWYKADNGMFFTGSNDKTVKIWDTN--RFEAVQDIN---------LGYKINQIDNNVVDDSS 252

  Fly   189 -LLAAAHDGDLRIWDIR-KGSCPTHYITAHLNRVHG----INWSHKRETCLATASQDGTVKYFDV 247
             |:.|:.|...|:.|:| ..|..|.....:..|:..    ..::..||..:|....:|.||.:|:
Yeast   253 LLVVASEDYYPRLIDLRTMNSGVTALGMGNQTRMQSEILCCKFNPVREQIIACGDMEGGVKLWDL 317

  Fly   248 CNPRRAEKIITTMSPVWRARYTPIGNGLVSIVVPHLGRGENSLLLWSNSKQTDPICS---FVGHT 309
               |...::.:.:... :.|:..|.|.                   .|..|:|...|   ...|.
Yeast   318 ---RMRNRLYSELKRN-KNRFKTINND-------------------DNDDQSDVYFSSNQSKAHL 359

  Fly   310 DVILDFAWRPNRESSNEIELVTWSRDRTLRVWK 342
            ....|..|  |.|.|   ||.:...|..|.||:
Yeast   360 RCCSDIVW--NSEGS---ELCSVGMDGKLNVWR 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr59	NP_609485.4	WD40	<92..343	CDD:225201	59/269 (22%)
		WD40 repeat	132..170	CDD:293791	10/38 (26%)
		WD40 repeat	178..213	CDD:293791	11/44 (25%)
		WD40 repeat	220..259	CDD:293791	8/42 (19%)
		WD40 repeat	263..306	CDD:293791	7/45 (16%)
		WD40 repeat	312..341	CDD:293791	9/28 (32%)
		mRING-H2-C3H3C2_WDR59	912..957	CDD:319606
		modified RING-H2 finger (C3H3C2-type)	914..953	CDD:319606
RAD28	NP_010313.3	WD40	1..386	CDD:225201	76/355 (21%)
		WD40 repeat	61..102	CDD:293791	5/23 (22%)
		WD40 repeat	108..170	CDD:293791	13/63 (21%)
		WD40 repeat	198..233	CDD:293791	10/36 (28%)
		WD40 repeat	241..279	CDD:293791	10/37 (27%)
		WD40 repeat	290..351	CDD:293791	14/83 (17%)
		WD40 repeat	362..388	CDD:293791	11/31 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344759
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930