DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr59 and WDR59

DIOPT Version :9

Sequence 1:	NP_609485.4	Gene:	Wdr59 / 34540	FlyBaseID:	FBgn0032339	Length:	969	Species:	Drosophila melanogaster
Sequence 2:	XP_005256203.1	Gene:	WDR59 / 79726	HGNCID:	25706	Length:	993	Species:	Homo sapiens

Alignment Length:	1032	Identity:	350/1032 - (33%)
Similarity:	512/1032 - (49%)	Gaps:	158/1032 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 NKYYEHRDSQATAMSVDYSGQWVLLAGRGHLALQRLGQDDGSLRRHERQSKYEVSVAEFAICPSR 97
            |...|.|||||||||||..||..:|:||..|.:..|.......|:..||||:::...::....|.
Human     9 NVVVEFRDSQATAMSVDCLGQHAVLSGRRFLYIVNLDAPFEGHRKISRQSKWDIGAVQWNPHDSF 73

  Fly    98 KEYCAIATSQHIDIVRWGTAEPHYEMSLRGHTRTVTDIDWHGKDPNLLVSCSIDTFSHIWDLREP 162
            ..|.|.:::|.:|:.:|.........:|:||||.::|:||...:|:|||:.|:||:.:|||:::.
Human    74 AHYFAASSNQRVDLYKWKDGSGEVGTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDT 138

  Fly   163 RKPALSLNAVCMSGATQVGFNRVSGNLLAAAHDGDLRIWDIRKGSCPTHYITAHLNRVHGINWSH 227
            |||.::|:||  :||:||.:|:.:.|.||.:||||:||||.||.|....|:.|||:::||::|..
Human   139 RKPTVALSAV--AGASQVKWNKKNANCLATSHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHP 201

  Fly   228 KRETCLATASQDGTVKYFDVCNPRRAEKIITTMSPVWRARYTPIGNGLVSIVVPHLGRGENSLLL 292
            ..|..|||:|||.:||::|...||:...|:....|||:|||||..||||:::||.| |.||||||
Human   202 DSEHILATSSQDNSVKFWDYRQPRKYLNILPCQVPVWKARYTPFSNGLVTVMVPQL-RRENSLLL 265

  Fly   293 WSNSKQTDPICSFVGHTDVILDFAWRPNRESSNEIELVTWSRDRTLRVWKIDDNMLKLCEPSAEE 357
            |:......|:.:||||.||:|:|.||..:|.|.:.:|||||||:|||:|::|..|.:||.....:
Human   266 WNVFDLNTPVHTFVGHDDVVLEFQWRKQKEGSKDYQLVTWSRDQTLRMWRVDSQMQRLCANDILD 330

  Fly   358 IESRFEPDLSELRVPTPPEFLHPRSILVAASLPISTGDGACNTLPMARSPSFGGGYYRREEPHIA 422
            ....|...:|.|  |.|.:.||             |.|     .....:.|.|.....:|:|  .
Human   331 GVDEFIESISLL--PEPEKTLH-------------TED-----TDHQHTASHGEEEALKEDP--P 373

  Fly   423 RSLTDQPTC-------SLHHEFSLLNTNMPHVEVDTLDAIKRYACFKICAGGHTVILQVTFTTSY 480
            |:|.::...       :|..||||:|..:.:|.|: :||..|.....:....|.|.:.|.|...|
Human   374 RNLLEERKSDQLGLPQTLQQEFSLINVQIRNVNVE-MDAADRSCTVSVHCSNHRVKMLVKFPAQY 437

  Fly   481 PSPSAPPDFQLCQGTTLSSEVSGVLLKVLRCNALQRVKKSRTCLEQCLRALVAAMKKKVAAVGGA 545
            |: :|.|.||....||::|.:...|||:|:..|||:||:.::|||.|||.||:.::..|.....|
Human   438 PN-NAAPSFQFINPTTITSTMKAKLLKILKDTALQKVKRGQSCLEPCLRQLVSCLESFVNQEDSA 501

  Fly   546 DRSQLLLQS---------PRLEGALSSTLHDACIPYPRTSGVHFNAIGMLTTFAQPVNNKRLTLR 601
            ..:...|.:         .|:..|..| ..||.||:|||||..|...|.|..|.:|:...|..
Human   502 SSNPFALPNSVTPPLPTFARVTTAYGS-YQDANIPFPRTSGARFCGAGYLVYFTRPMTMHRAV-- 563

  Fly   602 QHTALTPRTFSSING--SGLLGNVMATAQREAN------------------ASFYLQERMI---- 642
            ..|..|||:.|:::.  :||:..:....:...|                  :|||.:|||.
Human   564 SPTEPTPRSLSALSAYHTGLIAPMKIRTEAPGNLRLYSGSPTRSEKEQVSISSFYYKERMSPRSA 628

  Fly   643 -------------------SGKPGKQRAIRQMNGSPVVHVYDTSSLLHISRRMAREFSLDKCNIA 688
                               |.:.|.....||:..:..|.:.|.:.||.:.:.:...:.|:..:|.
Human   629 RRRWSIQAINDFPKSRRWKSKREGSDSGNRQIKAAGKVIIQDIACLLPVHKSLGELYILNVNDIQ 693

  Fly   689 ETCRKNGEICRQHGRLDLVPVWLLAEL-------------IATPQIPHETLNDLLFYKDPFKKSL 740
            |||:||.......||.|||.||.||.:             :.||...|           ||.:.|
Human   694 ETCQKNAASALLVGRKDLVQVWSLATVATDLCLGPKSDPDLETPWARH-----------PFGRQL 747

  Fly   741 LESLIMHYAISGDIQTAVLLACLFD--KCPTGGGAIMEKTVRLP------PQLNSQISPYHTVLP 797
            ||||:.||....|:||..:|..:|:  ..|.|          ||      |..:|.:...|:..|
Human   748 LESLLAHYCRLRDVQTLAMLCSVFEAQSRPQG----------LPNPFGPFPNRSSNLVVSHSRYP 802

  Fly   798 LDVKSSSSS-------NT--W----QQLKQLRSNSWSDSLDLEI----------KQIQSDAYACS 839
            ....|.|.|       ||  |    ::.:.| |:.|.:|...|:          ::.:.|.:..:
Human   803 SFTSSGSCSSMSDPGLNTGGWNIAGREAEHL-SSPWGESSPEELRFGSLTYSDPRERERDQHDKN 866

  Fly   840 --LIRRTKMPLFDQFKRAYAEILFGWQLLSKRALILKHTQNTPPPVQGVEFVTECRKCAKPKRTP 902
              |:.......||.||:.|.|||:.|.|..|||.:||.....|.|.:|:||...|..|....|..
Human   867 KRLLDPANTQQFDDFKKCYGEILYRWGLREKRAEVLKFVSCPPDPHKGIEFGVYCSHCRSEVRGT 931

  Fly   903 KCEPCKRPVLFCVLCRLPVKGAANACLACGHGGHIDHMMQWFEKHNVCAT-CGCKCL 958
            :|..||.....|.:|.:.|:|::|.||.||||||..|||:||....||.| |||.||
Human   932 QCAICKGFTFQCAICHVAVRGSSNFCLTCGHGGHTSHMMEWFRTQEVCPTGCGCHCL 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr59	NP_609485.4	WD40	<92..343	CDD:225201	116/250 (46%)
		WD40 repeat	132..170	CDD:293791	16/37 (43%)
		WD40 repeat	178..213	CDD:293791	17/34 (50%)
		WD40 repeat	220..259	CDD:293791	16/38 (42%)
		WD40 repeat	263..306	CDD:293791	23/42 (55%)
		WD40 repeat	312..341	CDD:293791	16/28 (57%)
		mRING-H2-C3H3C2_WDR59	912..957	CDD:319606	24/45 (53%)
		modified RING-H2 finger (C3H3C2-type)	914..953	CDD:319606	21/39 (54%)
WDR59	XP_005256203.1	WD40	<34..328	CDD:225201	129/296 (44%)
		WD40 repeat	62..103	CDD:293791	7/40 (18%)
		WD40	100..>343	CDD:295369	117/247 (47%)
		WD40 repeat	109..150	CDD:293791	19/42 (45%)
		WD40 repeat	154..188	CDD:293791	17/33 (52%)
		WD40 repeat	195..229	CDD:293791	15/33 (45%)
		WD40 repeat	237..279	CDD:293791	23/42 (55%)
		WD40 repeat	285..316	CDD:293791	17/30 (57%)
		RWD	394..494	CDD:214735	40/101 (40%)
		Zn_ribbon_17	943..991	CDD:305234	26/46 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141560
Domainoid	1	1.000	292	1.000	Domainoid score	I1530
eggNOG	1	0.900	-	-		E2759_KOG0309
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38685
Inparanoid	1	1.050	533	1.000	Inparanoid score	I1211
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45574
OrthoDB	1	1.010	-	-		D146113at33208
OrthoFinder	1	1.000	-	-		FOG0005787
OrthoInspector	1	1.000	-	-		oto90480
orthoMCL	1	0.900	-	-		OOG6_104242
Panther	1	1.100	-	-	LDO	PTHR46170
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4177
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770