DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr59 and Wdr59

DIOPT Version :9

Sequence 1:	NP_609485.4	Gene:	Wdr59 / 34540	FlyBaseID:	FBgn0032339	Length:	969	Species:	Drosophila melanogaster
Sequence 2:	XP_038954178.1	Gene:	Wdr59 / 690751	RGDID:	1592213	Length:	1003	Species:	Rattus norvegicus

Alignment Length:	1032	Identity:	353/1032 - (34%)
Similarity:	515/1032 - (49%)	Gaps:	148/1032 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 NKYYEHRDSQATAMSVDYSGQWVLLAGRGHLALQRLGQDDGSLRRHERQSKYEVSVAEFAICPSR 97
            |...|.|||||||||||..||..:|:||..|.:..|.......|:..||||:::...::....|.
  Rat     9 NVVVEFRDSQATAMSVDCVGQHAVLSGRRFLYIVNLDAPFEGHRKISRQSKWDIGAVQWNPHDSF 73

  Fly    98 KEYCAIATSQHIDIVRWGTAEPHYEMSLRGHTRTVTDIDWHGKDPNLLVSCSIDTFSHIWDLREP 162
            ..|.|.:::|.:|:.:|.........:|:||||.::|:||...:|:|||:.|:||:.:|||:::.
  Rat    74 AHYFAASSNQRVDLYKWKDGSGEVGTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDT 138

  Fly   163 RKPALSLNAVCMSGATQVGFNRVSGNLLAAAHDGDLRIWDIRKGSCPTHYITAHLNRVHGINWSH 227
            ||||::|:||  :||:||.:|:.:.|.||.:||||:||||.||.|....|:.|||:::||::|..
  Rat   139 RKPAVALSAV--AGASQVKWNKKNANYLATSHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHP 201

  Fly   228 KRETCLATASQDGTVKYFDVCNPRRAEKIITTMSPVWRARYTPIGNGLVSIVVPHLGRGENSLLL 292
            ..|...||:|||.:||::|...||:...|:....|||:|||||..||||:::||.| |.||||||
  Rat   202 DSEHIFATSSQDNSVKFWDYRQPRKYLNILPCQVPVWKARYTPFSNGLVTVMVPQL-RRENSLLL 265

  Fly   293 WSNSKQTDPICSFVGHTDVILDFAWRPNRESSNEIELVTWSRDRTLRVWKIDDNMLKLCEPSAEE 357
            |:......|:.:||||.||:|:|.||..:|.|.:.:|||||||:|||:|::|..|.:||.....:
  Rat   266 WNVFDLNTPVHTFVGHDDVVLEFQWRRQKEGSKDYQLVTWSRDQTLRMWRVDYQMQRLCANDILD 330

  Fly   358 IESRFEPDLSELRVPTPPEFLHPRSILVAASLPISTGDG-ACNTLPMARSPSFGGGYYRREEPHI 421
            ....|...:|.|  |.|.:.|||:......||.....|| ..:.|.:...|.......||
  Rat   331 GVDEFIESISLL--PEPEKTLHPQDTDHQPSLSHGEEDGNVTDVLAIKEDPPSSLLEERR----- 388

  Fly   422 ARSLTDQ---PTCSLHHEFSLLNTNMPHVEVDTLDAIKRYACFKICAGGHTVILQVTFTTSYPSP 483
                :||   |. :|..||||:|..:.:|.|: :||..|.....:....|.|.:.|||...||:
  Rat   389 ----SDQLGLPQ-TLQQEFSLINVQIRNVNVE-MDAADRSCTVSVHCSNHRVKMLVTFPAQYPN- 446

  Fly   484 SAPPDFQLCQGTTLSSEVSGVLLKVLRCNALQRVKKSRTCLEQCLRALVAAMKKKVAAVGGADRS 548
            :|.|.||....||::|.|...|||:|:..:||:||::::|||.|||.||:.::..|.....|..:
  Rat   447 NAAPSFQFINPTTITSAVKAKLLKILKDTSLQKVKRNQSCLEPCLRQLVSCLESFVNQEDSASSN 511

  Fly   549 QLLLQS---------PRLEGALSSTLHDACIPYPRTSGVHFNAIGMLTTFAQPVNNKRLTLRQHT 604
            ...|.:         .|:..|..| ..||.||:|||||..|...|.|..|.:|:...|..  ..|
  Rat   512 PFALPNSVTPPLPTFARVTTAYGS-YQDANIPFPRTSGARFCGAGYLVYFTRPMTMHRAV--SPT 573

  Fly   605 ALTPRTFSSING--SGLLGNVMATAQREAN------------------ASFYLQERMISGKPGKQ 649
            ..|||:.|:::.  :||:..:....:...|                  :|||.:|||......::
  Rat   574 EPTPRSLSALSAYHTGLIAPMKIRTEAPGNLRLYSGSPTRSEKEQVSISSFYYKERMSPRSARRR 638

  Fly   650 RAIRQMNGSP-----------------------VVHVYDTSSLLHISRRMAREFSLDKCNIAETC 691
            .:|:.:|..|                       .|.:.|.|.||.:.:.:...:.|:..:..|||
  Rat   639 WSIQAINDFPKSRRWKSKREGSDSGNRPIKAAGKVIIQDVSCLLPVHKSLGELYILNVNDTQETC 703

  Fly   692 RKNGEICRQHGRLDLVPVWLLAEL-------------IATPQIPHETLNDLLFYKDPFKKSLLES 743
            :||.......||.|||.||.||.:             :.||...|           ||.:.||||
  Rat   704 QKNATSAMLVGRKDLVQVWSLATVATDLCLGPKSDPDLETPWARH-----------PFGRQLLES 757

  Fly   744 LIMHYAISGDIQTAVLLACLFD--KCPTGGGAIMEKTVRLP------PQLNSQISPYHTVLPLDV 800
            |:.||....|:||..:|..:|:  ..|.|          ||      |..:|.....|:..|...
  Rat   758 LLAHYCRLRDVQTLAMLCSVFEAQSRPQG----------LPNPFGPFPNRSSNFVVSHSRYPSFT 812

  Fly   801 KSSSSS-------NT--W-------QQLKQLRSNSWSDSLDLEI----------KQIQSDAYACS 839
            .|.|.|       ||  |       ::.:.: |:.|.:|...|:          ::.:.|.:..:
  Rat   813 SSGSCSSMSDPGFNTGGWSIVSLAGRETEHI-SSPWGESSPEELRFGSLTYSDPRERERDQHDKN 876

  Fly   840 --LIRRTKMPLFDQFKRAYAEILFGWQLLSKRALILKHTQNTPPPVQGVEFVTECRKCAKPKRTP 902
              |:.......||.||:.|.|||:.|.|..|||.:||.....|.|.:|:||...|..|....|..
  Rat   877 KRLLDPANTQQFDDFKKCYGEILYRWGLREKRAEVLKFVSCPPDPHKGIEFGVYCSHCRSEVRGT 941

  Fly   903 KCEPCKRPVLFCVLCRLPVKGAANACLACGHGGHIDHMMQWFEKHNVCAT-CGCKCL 958
            :|..||.....|.:|.:.|:|::|.||.||||||..|||:||....||.| |||.||
  Rat   942 QCAICKGFTFQCAICHVAVRGSSNFCLTCGHGGHTSHMMEWFRTQEVCPTGCGCHCL 998

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr59	NP_609485.4	WD40	<92..343	CDD:225201	116/250 (46%)
		WD40 repeat	132..170	CDD:293791	17/37 (46%)
		WD40 repeat	178..213	CDD:293791	17/34 (50%)
		WD40 repeat	220..259	CDD:293791	15/38 (39%)
		WD40 repeat	263..306	CDD:293791	23/42 (55%)
		WD40 repeat	312..341	CDD:293791	16/28 (57%)
		mRING-H2-C3H3C2_WDR59	912..957	CDD:319606	24/45 (53%)
		modified RING-H2 finger (C3H3C2-type)	914..953	CDD:319606	21/39 (54%)
Wdr59	XP_038954178.1	WD40	<34..314	CDD:225201	121/279 (43%)
		WD40 repeat	62..103	CDD:293791	7/40 (18%)
		WD40 repeat	109..150	CDD:293791	20/40 (50%)
		WD40 repeat	154..188	CDD:293791	17/33 (52%)
		WD40 repeat	195..229	CDD:293791	14/33 (42%)
		WD40 repeat	237..279	CDD:293791	24/41 (59%)
		WD40 repeat	285..316	CDD:293791	17/30 (57%)
		RWD	401..501	CDD:214735	38/102 (37%)
		mRING-H2-C3H3C2_WDR59	951..997	CDD:319606

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335248
Domainoid	1	1.000	279	1.000	Domainoid score	I1627
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38685
Inparanoid	1	1.050	459	1.000	Inparanoid score	I1517
OMA	1	1.010	-	-		QHG45574
OrthoDB	1	1.010	-	-		D146113at33208
OrthoFinder	1	1.000	-	-		FOG0005787
OrthoInspector	1	1.000	-	-		oto97589
orthoMCL	1	0.900	-	-		OOG6_104242
Panther	1	1.100	-	-	LDO	PTHR46170
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4177
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910