DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wdr59 and l(2)09851

DIOPT Version :9

Sequence 1:	NP_609485.4	Gene:	Wdr59 / 34540	FlyBaseID:	FBgn0032339	Length:	969	Species:	Drosophila melanogaster
Sequence 2:	NP_001260713.1	Gene:	l(2)09851 / 46662	FlyBaseID:	FBgn0022288	Length:	456	Species:	Drosophila melanogaster

Alignment Length:	274	Identity:	65/274 - (23%)
Similarity:	105/274 - (38%)	Gaps:	47/274 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 YSGQWVLLAGRGHLALQRLGQDDGSLRRHERQSKYEVSVAE------------FAICPSRKEYCA 102
            |:..|..|   |.:.:..|.|...::...:...:||.|.|.            |||..|......
  Fly   176 YAASWSEL---GRVNIWDLTQPLQAVENAQLAKQYEQSEARPVFTFGGHQQEGFAIDWSPSADGV 237

  Fly   103 IATSQ-HIDIVRWGTAEPHY----EMSLRGHTRTVTDIDWHGKDPNLLVSCSIDTFSHIWDLR-E 161
            :||.. ..||..|...|...    :..|.||:::|.|:.|...:.::|.|||:|....|||.| .
  Fly   238 LATGDCRRDIHVWTPVEDGTWKVDQRPLAGHSQSVEDLQWSPNERSVLASCSVDKTIRIWDCRAS 302

  Fly   162 PRKPA-LSLNAVCMSGATQVGFNRVSGNLLAAAHDGDLRIWDIR--KGSCPTHYITAHLNRVHGI 223
            |:|.. |:......|....:.:||....:.:...||.|.|||:|  :...|......|.:.:..:
  Fly   303 PQKACMLTCEDAHQSDVNVISWNRNEPFIASGGDDGYLHIWDLRQFQSKKPIATFKHHTDHITTV 367

  Fly   224 NWSHKRETCLATASQDGTVKYFDVC---------NPRRAEKIITTMSPVWRARYTPIGNGLVSIV 279
            .||....|.||:...|..:..:|:.         :|.:.|.::..:.|              .::
  Fly   368 EWSPAEATVLASGGDDDQIALWDLAVEKDIDQAVDPAQNEDVLNKLPP--------------QLL 418

  Fly   280 VPHLGRGENSLLLW 293
            ..|.|:.|...|.|
  Fly   419 FIHQGQKEIKELHW 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr59	NP_609485.4	WD40	<92..343	CDD:225201	54/220 (25%)
		WD40 repeat	132..170	CDD:293791	15/39 (38%)
		WD40 repeat	178..213	CDD:293791	10/36 (28%)
		WD40 repeat	220..259	CDD:293791	9/47 (19%)
		WD40 repeat	263..306	CDD:293791	5/31 (16%)
		WD40 repeat	312..341	CDD:293791
		mRING-H2-C3H3C2_WDR59	912..957	CDD:319606
		modified RING-H2 finger (C3H3C2-type)	914..953	CDD:319606
l(2)09851	NP_001260713.1	CAF1C_H4-bd	53..120	CDD:289068
		WD40	152..>395	CDD:295369	57/221 (26%)
		WD40	<172..>447	CDD:225201	65/274 (24%)
		WD40 repeat	226..267	CDD:293791	11/40 (28%)
		WD40 repeat	272..312	CDD:293791	15/39 (38%)
		WD40 repeat	320..357	CDD:293791	10/36 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456803
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840