Protein Alignment Wdr59 and Wdr24

DIOPT Version :10

• Sequence 1: NP_609485.4
• Gene: Wdr59 / 34540
• FlyBaseID: FBgn0032339
• Length: 969
• Species: Drosophila melanogaster
• Sequence 2: NP_733303.2
• Gene: Wdr24 / 43505
• FlyBaseID: FBgn0027518
• Length: 777
• Species: Drosophila melanogaster
• Alignment Length: 1015
• Identity: 203/1015 - (20%)
• Similarity: 350/1015 - (34%)
• Gaps: 355/1015 - (34%)

  Fly    40 DSQATAMSVDYSGQWVLLAGRGHLALQRLGQDDGSLRRHERQSKYEVSVAEFAICPSRKEYCAIA 104
            :..|.|::::.....:.||||..|.:..:..:..:...:.|.....:|.:...:..|..:...:|
  Fly    18 EGHANALALNKDNNQIALAGRSLLKVYSINSNGFTESCNMRGKNQNLSYSANDVAWSTLDSNLLA 82

  Fly   105 TSQHIDIVR-WGTAEPHYEMSL---RGHTRTVTDIDWHGKDPNLLVSCSIDTFSHIWDLREPRKP 165
            |:....:|. |..::...:..|   ..|.||...:.:|..:||:|:|.|.|.....:|:|..:
  Fly    83 TAATNGVVSVWDLSKFGRQKQLLVYNEHERTAHTVTFHSSEPNILISGSQDGTIKCFDIRSDK-- 145

  Fly   166 ALSLNA-VCMSGATQ-VGFNRVSGNLLAA-AHDGDLRIWDIRK-GSCPTHYITAHLNRVHGINWS 226
              |:|. .|.|.:.: |.|:..:.|:.:| :.:|.:::||:|| ..|...: |||...|:..:|
  Fly   146 --SINTYFCNSESVRDVKFSPHTQNIFSAVSENGTVQLWDMRKWDKCMVQF-TAHYGPVYTCDW- 206

  Fly   227 HKRETCLATASQDGTVKYFDVCNPRRAEKIITTMSPVWRARYTP-----IGNGLVSIVVPHLGRG 286
            |.....|||.|:|..:|.:::......|..|.|::.|.|.::.|     |.:  .::||.:
  Fly   207 HPTRNWLATGSRDKQIKVWNMDGRPGLEHTIHTIAVVGRVKWRPERTYHIAS--CALVVDY---- 265

  Fly   287 ENSLLLWSNSKQTDPICSFVGHTDVILDFAWRPNRESSNEIELVTWSRDRTLRVWKIDDNMLKLC 351
              |:.:|...:...|..||..||:|....||    :.|:...|::.|:|.|:......|......
  Fly   266 --SVHVWDIRRPYIPFASFNEHTNVTTGIAW----QGSDSHCLLSISKDSTIYKHAFKDATRPAL 324

  Fly   352 EPSAEEIE-SRFEPDLSELRVPTPPEFLHPRSILVAASLPISTGDGACNTLPMARSPSFGGGYYR 415
            :.:|:... .||    .::......:...|::            .||.||    :|.||    ..
  Fly   325 KANAQGASLGRF----GDISFANKIKEYEPKT------------SGASNT----KSSSF----IS 365

  Fly   416 REEPHIARSLTDQPTCSLHHEFSLLNTNMPHVEVDTLDAIKRYACFKICAGGHTVILQVTFTTSY 480
            |.:.::|.|:          :|.|.::.|                       :..::..|| :.|
  Fly   366 RRKTNVAGSI----------QFHLDHSKM-----------------------YKFMVNDTF-SGY 396

  Fly   481 PSPSAPPDFQLCQGTTLSSEVSGVLLKVLRCNALQRVKKSRTCLEQCLRALVAAMKKKVAAVGGA 545
            |               ||..||             |..:.......|.|.||.:.||
  Fly   397 P---------------LSESVS-------------RPTQEHESFIGCARELVISGKK-------- 425

  Fly   546 DRSQLLLQSPRLEGALSSTLHDACIPYPRTS---GVH-----FNAIGML-------------TTF 589
                               |.:.|......|   |.|     :|.|.:.             ::|
  Fly   426 -------------------LSELCEHNAEVSKKYGKHNATTLWNFIKLFYGSNHFEPPFEHRSSF 471

  Fly   590 A---QPVNNKRLTL------RQHTALTPRTFSSINGSGLLGNVMATAQREANASFYLQERMISGK 645
            :   .|:|::|.|.      :|.|.|         |..|.||...|| .|.:.:....:.:
  Fly   472 SNQKNPMNSRRATQVASDWPQQRTEL---------GQDLNGNTPETA-HEIDVANVDDDTL---- 522

  Fly   646 PGKQRAIRQMNGSPVVHVYDTSSLLHISRRMAREFSLDKCNIAET---------CRK-------N 694
                       ||..|....|||::....::..|.:.|...:...         |.|       :
  Fly   523 -----------GSSGVEHPPTSSVILSETQIISEITFDNFELLRNGFIYVGPTECPKALAFPALH 576

  Fly   695 GEICRQHGRLDL------------------------VPVWLLAELIATPQIPHETLNDLLFYKDP 735
            .::.....:|||                        :|:|          .||:.::|.|
  Fly   577 HDVQAARPQLDLKASDHEKSPPPHVPTVLKVSHVPPIPMW----------EPHKFVSDAL----- 626

  Fly   736 FKKSLLESLIMHYAISGDIQTA--VLLACLFDKCPTGGGAIMEKTVRLPPQLNSQISPYHTVLPL 798
                    ::|:..  ||:|||  ||:|                           :.....:||:
  Fly   627 --------MLMNDV--GDVQTALTVLIA---------------------------LGEARKLLPI 654

  Fly   799 DVKSSSSSNTW--QQLKQL-RSNSWSDSLDLEIKQIQSDAYACSLIRRTKMPLFDQFKRAYAEIL 860
            |   .:....|  ..:.|| |...|::              ||.:|.|:
  Fly   655 D---DALVEHWFYTYVDQLHRYELWNE--------------ACEVINRS---------------- 686

  Fly   861 FGW----QLLSKRALILKHTQNTPPPVQGVEFVTECRKCAKP---KRTPKCEPCK-RPVLFCVLC 917
              |    |.|::.:..:.               |.|.:|.:|   |....|:.|| .....|.:|
  Fly   687 --WLRSVQQLNQHSTAMH---------------TNCGECGRPMGGKVGWYCDKCKSMQSAKCCVC 734

  Fly   918 RLPVKGAANACLACGHGGHIDHMMQWFEKHNVCATCGCKC 957
            .|.|:|....|..|.|||||:|:.::|.||:.|..||..|
  Fly   735 GLIVRGVYAWCQGCSHGGHIEHLQKYFAKHSKCPKCGHLC 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wdr59	NP_609485.4	WD40	<47..345	CDD:441893	75/310 (24%)
		WD40 repeat	132..170	CDD:293791	10/37 (27%)
		WD40 repeat	178..213	CDD:293791	10/37 (27%)
		WD40 repeat	220..259	CDD:293791	11/38 (29%)
		WD40 repeat	263..306	CDD:293791	10/47 (21%)
		WD40 repeat	312..341	CDD:293791	7/28 (25%)
		mRING-H2-C3H3C2_WDR59	912..957	CDD:438353	19/44 (43%)
Wdr24	NP_733303.2	WD40	13..311	CDD:238121	76/310 (25%)
		WD40 repeat	70..109	CDD:293791	6/38 (16%)
		WD40 repeat	115..152	CDD:293791	11/40 (28%)
		WD40 repeat	157..194	CDD:293791	10/36 (28%)
		WD40 repeat	202..236	CDD:293791	9/34 (26%)
		WD40 repeat	243..283	CDD:293791	10/47 (21%)
		mRING-H2-C3H3C2_WDR24	730..774	CDD:438354	19/43 (44%)