DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr59 and Wdr24

DIOPT Version :9

Sequence 1:	NP_609485.4	Gene:	Wdr59 / 34540	FlyBaseID:	FBgn0032339	Length:	969	Species:	Drosophila melanogaster
Sequence 2:	NP_001178013.1	Gene:	Wdr24 / 360497	RGDID:	1304803	Length:	790	Species:	Rattus norvegicus

Alignment Length:	949	Identity:	201/949 - (21%)
Similarity:	337/949 - (35%)	Gaps:	214/949 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 HRDSQATAMSVDYSGQWVLLAGRGHLALQRLGQDDGSLR---RHERQSKYEVSVAEFAICPSRKE 99
            |.|:.|.|:||......|::|||....:..:.::....:   |..|:....:|.|:.......:.
  Rat    24 HLDAPANAISVCRDAAQVVVAGRSIFKIYAIEEEQFVEKLNLRVGRKPSLNLSCADVVWHQMDEN 88

  Fly   100 YCAIATSQHIDIVRWGTAEP---HYEMSLRGHTRTVTDIDWHGKDPNLLVSCSIDTFSHIWDLRE 161
            ..|.|.:..: :|.|....|   ..:.....|.|||..:.:|..:.::|:|.|.|.|...:|||
  Rat    89 LLATAATNGV-VVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLR- 151

  Fly   162 PRKPALSLNAVCMSGATQVGFN-RVSGNLLAAAHDGDLRIWDIRKGSCPTHYITAHLNRVHGINW 225
             ||.::|..:........|.|: |......:...:|::::||||:........|||...|...:|
  Rat   152 -RKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCERMFTAHNGPVFCCDW 215

  Fly   226 SHKRETCLATASQDGTVKYFDVCNPRRAEKI--ITTMSPVWRARYTPIGN---GLVSIVVPHLGR 285
            ..:....|||..:|..||.:|: ...||::|  :.|::.|.|.::.|...   ...|::|.|
  Rat   216 HPEDRGWLATGGRDKMVKVWDM-TTHRAKEIHCVQTIASVARVKWRPECRHHLATCSMMVDH--- 276

  Fly   286 GENSLLLWSNSKQTDPICSFVGHTDVILDFAWRPNRESSNEIELVTWSRDRTLRVWKIDDNMLKL 350
               ::.:|...:...|...|..|.||....|||...:.|   .|::.|:|.|            |
  Rat   277 ---NIYVWDVRRPFVPAAMFEEHRDVTTGIAWRHPHDPS---FLLSGSKDST------------L 323

  Fly   351 CEPSAEEIESRFEPDLSELRVPTPPEFLHPRSILVAASLPISTGDGACNTLPMARSPSFGGGYYR 415
            |:        ....|.|:     |.|..:|              :|.|..|       ||...:.
  Rat   324 CQ--------HLFRDASQ-----PVERANP--------------EGLCYGL-------FGDLAFA 354

  Fly   416 REEPHIARSLTDQPTCSLHHEFSLLNTNMPHVEVDTLDAIKRYACFKICAGGHTVILQVTFTTSY 480
            .:|..:|.....:|..............:...|..:..|....:.|:..:||.::...|.....|
  Rat   355 VKESLVAAESGRKPYAGDRRHPIFFKRKLDPAEPFSGLASSALSVFETESGGGSMSWFVDTAERY 419

  Fly   481 PSPSAPPDFQLCQGTTLSSEVSGVLLKVLRCNALQRVKKSRTCLE--QCLRALVAAMKKKVAAVG 543
             :.:..|..:||....          ||.|.....:|.::.|.|.  .|...||::.....:...
  Rat   420 -ALAGRPLAELCDHNA----------KVARELGRNQVAQTWTMLRIIYCSPGLVSSANLNHSVGK 473

  Fly   544 GADRSQLLLQSPRLE----GALSSTLHDACIPYPRTSGVHFNAIGMLTTFAQPVNNKRLTLRQHT 604
            |:..|..|:.|..|:    |..|.|..|      |:.|...:...:|.:.|..:.|:.   .:.|
  Rat   474 GSSCSLPLMNSFNLKDMGPGLGSETRLD------RSKGDTRSDTVLLDSSATLITNED---NEET 529

  Fly   605 ALTPRTFSSINGSGLLGNVMATAQREANASFYLQERMISGKPGKQRAIRQMNGSPVVH-VYDTSS 668
                 ..|.:....|||:|    :.|.:..:.|....:  .|.:...:......|:.| :.||.|
  Rat   530 -----EGSDVPADYLLGDV----EGEEDELYPLDTEHV--HPEEPEYVLPQEAFPLRHEIVDTPS 583

  Fly   669 LLHISRRMAREFSLDKC-------NIAETCRKNGEICRQHGRLDLVPVWLLAELIATPQIPHETL 726
                    ..|...||.       |.|:|.             .|.||...:.|::   :.|...
  Rat   584 --------GPEHLQDKADSPHVSGNEADTA-------------SLAPVDSSSSLLS---VSHALY 624

  Fly   727 NDLLFYKDPFKKSLLESLIMHYAISGDIQTAVLLACLFDKCPTGGGAIMEKTVRLPPQLNSQISP 791
            :..|  ...|...|:..::..||..||:|.||.:..:..:             |:...::.|...
  Rat   625 DSRL--PPDFFSVLVRDMLHFYAEQGDVQMAVSVLIVLGE-------------RVRKDIDEQTQE 674

  Fly   792 YHTVLPLDVKSSSSSNTWQQLKQLRSNSWSDSLDLEIKQIQSDAYACSLIRRTKMPLFDQFKRAY 856
            :.....:|:..             |...|:.|.:: :|...|.|.:|
  Rat   675 HWYTSYIDLLQ-------------RFCLWNVSNEV-VKLSTSRAVSC------------------ 707

  Fly   857 AEILFGWQLLSKRALILKHTQNTPPPVQGVEFVTECRKCAKP--KRTPKCEPCKRPVLFCVLCRL 919
                     |::.:..|.               ..|..|.:|  .|...|:.|:|....|.:|..
  Rat   708 ---------LNQASTTLH---------------VNCSHCKRPMSSRGWVCDRCRRCASMCAVCHH 748

  Fly   920 PVKGAANACLACGHGGHIDHMMQWFEKHNVC-ATCGCKC 957
            .|||....|..|.||||:.|:|:|.|..:.| |.||..|
  Rat   749 VVKGLFVWCQGCSHGGHLQHIMKWLEGSSHCPAGCGHLC 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr59	NP_609485.4	WD40	<92..343	CDD:225201	65/259 (25%)
		WD40 repeat	132..170	CDD:293791	13/37 (35%)
		WD40 repeat	178..213	CDD:293791	8/35 (23%)
		WD40 repeat	220..259	CDD:293791	12/40 (30%)
		WD40 repeat	263..306	CDD:293791	8/45 (18%)
		WD40 repeat	312..341	CDD:293791	8/28 (29%)
		mRING-H2-C3H3C2_WDR59	912..957	CDD:319606	19/45 (42%)
		modified RING-H2 finger (C3H3C2-type)	914..953	CDD:319606	17/39 (44%)
Wdr24	NP_001178013.1	WD40 repeat	75..118	CDD:293791	7/43 (16%)
		WD40	<86..323	CDD:421866	65/261 (25%)
		WD40 repeat	124..161	CDD:293791	12/38 (32%)
		WD40 repeat	166..203	CDD:293791	8/36 (22%)
		WD40 repeat	211..247	CDD:293791	11/36 (31%)
		WD40 repeat	254..294	CDD:293791	8/45 (18%)
		mRING-H2-C3H3C2_WDR24	742..787	CDD:319607	19/44 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D146113at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920