DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr59 and Wdr24

DIOPT Version :9

Sequence 1:	NP_609485.4	Gene:	Wdr59 / 34540	FlyBaseID:	FBgn0032339	Length:	969	Species:	Drosophila melanogaster
Sequence 2:	NP_776102.1	Gene:	Wdr24 / 268933	MGIID:	2446285	Length:	790	Species:	Mus musculus

Alignment Length:	967	Identity:	207/967 - (21%)
Similarity:	339/967 - (35%)	Gaps:	250/967 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 HRDSQATAMSVDYSGQWVLLAGRGHLALQRLGQDDGSLR---RHERQSKYEVSVAEFAICPSRKE 99
            |.|:.|.|:||......|::|||....:..:.::....:   |..|:....:|.|:.......:.
Mouse    24 HLDAPANAISVCRDAAQVVVAGRSIFKIYAIEEEQFVEKLNLRVGRKPSLNLSCADVVWHQMDEN 88

  Fly   100 YCAIATSQHIDIVRWGTAEP---HYEMSLRGHTRTVTDIDWHGKDPNLLVSCSIDTFSHIWDLRE 161
            ..|.|.:..: :|.|....|   ..:.....|.|||..:.:|..:.::|:|.|.|.|...:|||
Mouse    89 LLATAATNGV-VVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLR- 151

  Fly   162 PRKPALSLNAVCMSGATQVGFN-RVSGNLLAAAHDGDLRIWDIRKGSCPTHYITAHLNRVHGINW 225
             ||.::|..:........|.|: |......:...:|::::||||:........|||...|...:|
Mouse   152 -RKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCERMFTAHNGPVFCCDW 215

  Fly   226 SHKRETCLATASQDGTVKYFDVCNPRRAEKI--ITTMSPVWRARYTPIGN---GLVSIVVPHLGR 285
            ..:....|||..:|..||.:|: ...||::|  :.|::.|.|.::.|...   ...|::|.|
Mouse   216 HPEDRGWLATGGRDKMVKVWDM-TTHRAKEIHCVQTIASVARVKWRPECRHHLATCSMMVDH--- 276

  Fly   286 GENSLLLWSNSKQTDPICSFVGHTDVILDFAWRPNRESSNEIELVTWSRDRTLRVWKIDDNMLKL 350
               ::.:|...:...|...|..|.||....|||...:.|   .|::.|:|.||        ...|
Mouse   277 ---NIYVWDVRRPFVPAAMFEEHRDVTTGIAWRHPHDPS---FLLSGSKDSTL--------CQHL 327

  Fly   351 CEPSAEEIESRFEP---------DLSELRVPTPPEFLHPRSILVAASLPISTGDGACNTLPMARS 406
            ...:::.:| |..|         ||:         |....|::.|.|               .|.
Mouse   328 FRDASQPVE-RANPEGLCYGLFGDLA---------FAVKESLVAAES---------------GRK 367

  Fly   407 PSFGGGYYRREEPHIARSLTDQPTCSLHHEFSLLNTNMPHVEVDT--------LDAIKRYACFKI 463
            |..|.   ||......|.|......|     .|.::.:...|.::        :|..:||    :
Mouse   368 PYAGD---RRHPIFFKRKLDPAEPFS-----GLASSALSVFETESSGGSMSWFVDTAERY----V 420

  Fly   464 CAGGHTVILQVTFTTSYPSPSAPPDFQLCQGTTLSSEVSGVLLKVLRCNALQRVKKSRTCLE--Q 526
            .||                   .|..:||....          ||.|.....:|.::.|.|.  .
Mouse   421 LAG-------------------RPLAELCDHNA----------KVARELGRNQVAQTWTMLRIIY 456

  Fly   527 CLRALVAAMKKKVAAVGGADRSQLLLQSPRLE----GALSSTLHDACIPYPRTSGVHFNAIGMLT 587
            |...||::.....:...|:.....|:.|..|:    |..|.|..|      |:.|...:...:|.
Mouse   457 CSPGLVSSANLNHSVGKGSSCGLPLMNSFNLKDMGPGLGSETRLD------RSKGDTRSDAALLD 515

  Fly   588 TFAQPVNNKRLTLRQHTALTPRTFSSINGSGLLGNVMATAQREANASFYLQ-ERMISGKPGKQRA 651
            :.|..|.|:.   .:.|     ..|.:....|||:|    :.|.:..:.|. |.:.|.:|   ..
Mouse   516 SSATLVTNED---NEET-----EGSDVPADYLLGDV----EGEDDELYPLDTEHVHSEEP---EY 565

  Fly   652 IRQMNGSPVVH-VYDTSSLLHISRRMAREFSLDKC-------NIAETCRKNGEICRQHGRLDLVP 708
            :......|:.| :.||.|        ..|...||.       |.|:|.             .|.|
Mouse   566 VLPQEAFPLRHEIVDTPS--------GPEHLQDKADSPHVSGNEADTA-------------SLAP 609

  Fly   709 VWLLAELIATPQIPHETLNDLLFYKDPFKKSLLESLIMHYAISGDIQTAVLLACLFDKCPTGGGA 773
            |...:.|::   :.|...:..|  ...|...|:..::..||..||:|.||.:..:..:
Mouse   610 VDSSSSLLS---VSHALYDSRL--PPDFFSVLVRDMLRFYAEQGDVQMAVSVLIVLGE------- 662

  Fly   774 IMEKTVRLPPQLNSQISPYHTVLPLDVKSSSSSNTWQQLKQLRSNSWSDSLDLEIKQIQSDAYAC 838
                  |:...::.|...:.....:|:..             |...|:.|.:: :|...|.|.:|
Mouse   663 ------RVRKDIDEQTQEHWYTSYIDLLQ-------------RFCLWNVSNEV-VKLSTSRAVSC 707

  Fly   839 SLIRRTKMPLFDQFKRAYAEILFGWQLLSKRALILKHTQNTPPPVQGVEFVTECRKCAKP--KRT 901
                                       |::.:..|.               ..|..|.:|  .|.
Mouse   708 ---------------------------LNQASTTLH---------------VNCSHCKRPMSSRG 730

  Fly   902 PKCEPCKRPVLFCVLCRLPVKGAANACLACGHGGHIDHMMQWFEKHNVC-ATCGCKC 957
            ..|:.|.|....|.:|...|||....|..|.||||:.|:|:|.|..:.| |.||..|
Mouse   731 WVCDRCHRCASMCAVCHHVVKGLFVWCQGCSHGGHLQHIMKWLEGSSHCPAGCGHLC 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr59	NP_609485.4	WD40	<92..343	CDD:225201	66/259 (25%)
		WD40 repeat	132..170	CDD:293791	13/37 (35%)
		WD40 repeat	178..213	CDD:293791	8/35 (23%)
		WD40 repeat	220..259	CDD:293791	12/40 (30%)
		WD40 repeat	263..306	CDD:293791	8/45 (18%)
		WD40 repeat	312..341	CDD:293791	9/28 (32%)
		mRING-H2-C3H3C2_WDR59	912..957	CDD:319606	19/45 (42%)
		modified RING-H2 finger (C3H3C2-type)	914..953	CDD:319606	17/39 (44%)
Wdr24	NP_776102.1	WD40	40..>323	CDD:225201	72/295 (24%)
		WD 1	72..112		7/40 (18%)
		WD40 repeat	75..118	CDD:293791	7/43 (16%)
		WD40	<86..323	CDD:295369	64/249 (26%)
		WD 2	118..158		15/41 (37%)
		WD40 repeat	124..161	CDD:293791	12/38 (32%)
		WD 3	161..201		8/39 (21%)
		WD40 repeat	166..203	CDD:293791	8/36 (22%)
		WD 4	205..245		13/40 (33%)
		WD40 repeat	211..247	CDD:293791	11/36 (31%)
		WD 5	249..291		9/47 (19%)
		WD40 repeat	254..294	CDD:293791	8/45 (18%)
		WD 6	295..338		14/54 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	516..537		5/28 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	579..607		9/48 (19%)
		Zn_ribbon_17	742..787	CDD:305234	19/44 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D146113at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920