DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr59 and wdr59

DIOPT Version :9

Sequence 1:	NP_609485.4	Gene:	Wdr59 / 34540	FlyBaseID:	FBgn0032339	Length:	969	Species:	Drosophila melanogaster
Sequence 2:	XP_009291658.1	Gene:	wdr59 / 103909113	ZFINID:	ZDB-GENE-120215-187	Length:	982	Species:	Danio rerio

Alignment Length:	1028	Identity:	341/1028 - (33%)
Similarity:	511/1028 - (49%)	Gaps:	153/1028 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 NKYYEHRDSQATAMSVDYSGQWVLLAGRGHLALQRLGQDDGSLRRHERQSKYEVSVAEFAICPSR 97
            |...|.||:||.|||||..||..:|:||..|.:..|.....:.|:..||||::|...::....|.
Zfish     9 NVVVEFRDAQANAMSVDCLGQHAVLSGRRFLYVVNLETPSEAPRKISRQSKWDVGTVQWNPHKSD 73

  Fly    98 KEYCAIATSQHIDIVRW--GTAEPHYEMSLRGHTRTVTDIDWHGKDPNLLVSCSIDTFSHIWDLR 160
            ....|.:::|.:|:..|  |:.:.|  .||:||||.::|:||...:|..||:.|:||:.:|||..
Zfish    74 AHIFAASSNQRVDLYTWRDGSGKSH--TSLQGHTRVISDLDWSWFEPEFLVTSSVDTYIYIWDTS 136

  Fly   161 EPRKPALSLNAVCMSGATQVGFNRVSGNLLAAAHDGDLRIWDIRKGSCPTHYITAHLNRVHGINW 225
            :.|:|.::|:||  :||:||.:||.:...||::||||:||||.||.:....|:.|||::::|::|
Zfish   137 DTRRPTVTLSAV--AGASQVKWNRRNHYCLASSHDGDVRIWDKRKSNTAVEYVAAHLSKINGLDW 199

  Fly   226 SHKRETCLATASQDGTVKYFDVCNPRRAEKIITTMSPVWRARYTPIGNGLVSIVVPHLGRGENSL 290
            ....|..|||:|||.:|:::|...||:...|::...|||:|||||..||||:::||.| |.||||
Zfish   200 HPDNEYILATSSQDNSVRFWDYRQPRKYLDILSCQVPVWKARYTPFSNGLVTVMVPQL-RRENSL 263

  Fly   291 LLWSNSKQTDPICSFVGHTDVILDFAWRPNRESSNEIELVTWSRDRTLRVWKIDDNMLKLCEPSA 355
            ||||..:...|:.:||||.||:.:|.|||.:|.|.:.:|||.|||:|||:|::|..:.|||  .|
Zfish   264 LLWSTLELNSPVHAFVGHDDVVYEFQWRPQKEGSKDCQLVTLSRDQTLRIWRVDPQLQKLC--CA 326

  Fly   356 EEIESRFEPDLSELRVPTPPEFLHPRSILVAASLPISTGDGACNTLPMARSPSFGGGYYRREEPH 420
            .||       :.||...|........|     ..|:|.|..|.|:|.....|..|
Zfish   327 NEI-------VDELTTETEKTLRSQDS-----EPPLSPGFTADNSLDQFDGPQSG---------- 369

  Fly   421 IARSLTDQPTCSLHHEFSLLNTNMPHVEVDTLDAIKRYACF-KICAGGHTVILQVTFTTSYPSPS 484
            ::.|..:....:|..||||:|..:.:|.|: :||:.| :|| ....|.:.|.|.|.|...||: :
Zfish   370 LSSSAKNDIPQTLQQEFSLVNLQIRNVNVE-MDAVNR-SCFVSADCGANRVRLVVKFPAQYPN-N 431

  Fly   485 APPDFQLCQGTTLSSEVSGVLLKVLRCNALQRVKKSRTCLEQCLRALVAAMKKKVAAVGGADRSQ 549
            |.|.||....|.:||.:...:.|:|...:||:||:::.|||.|:|.||:.::.......|::...
Zfish   432 AAPSFQFVPPTNISSSMKIKIQKILTDTSLQKVKRNQNCLEPCVRQLVSCLESDGVMEDGSNPYV 496

  Fly   550 L-------LLQSPRLEGALSSTLHDACIPYPRTSGVHFNAIGMLTTFAQPVNNKRLTLRQHTALT 607
            |       |...||:.....| ..||.||:|||||..|...|.|..|.:|:...|.|  ..|..|
Zfish   497 LTNPVTPALPAFPRVTNTYGS-YQDANIPFPRTSGARFCGTGSLVYFTRPMTMHRAT--PPTEPT 558

  Fly   608 PRTFSSING--SGLL-----------------GNVMATAQREAN-ASFYLQERMISGKP------ 646
            ||:.|:::.  ||::                 |:...|.:.:.: :|||.:||    ||
Zfish   559 PRSLSALSAYHSGVMTPMKMRTESQTTLRLYSGSPTRTDKDQVSISSFYYKER----KPLSAARR 619

  Fly   647 ----------------GKQRAIRQMNGSPV-----VHVYDTSSLLHISRRMAREFSLDKCNIAET 690
                            ||:.. ...:..|:     |.:.:.|.||.:.:.:...:.|:..:|.:|
Zfish   620 WSVQTIHECPKSRRWKGKREG-GDYSNRPIKLAGKVIIQEISCLLSVHKALGETYVLNVNDIQDT 683

  Fly   691 CRKNGEICRQHGRLDLVPVWLLAEL-------------IATPQIPHETLNDLLFYKDPFKKSLLE 742
            |:|||.......|.||..||.||..             ..||...|           ||.:.|||
Zfish   684 CQKNGAAALAVARRDLAKVWALASASTNLNLSPDPDPDAGTPWAKH-----------PFGRHLLE 737

  Fly   743 SLIMHYAISGDIQTAVLLACLFDKCPTGGGAIMEKTVRLPPQ--LNSQISPYHTVLPLDVKS--- 802
            :|:.||:...|:|:..:|..:|    .|.|:..|.......|  ..:..:|:|:..|....|
Zfish   738 TLLEHYSQLSDVQSLAMLCSVF----RGHGSPQEYFTLYGHQQPRPAVFTPHHSRYPSFTSSSVT 798

  Fly   803 -------SSSSNT-WQQ--LKQLRSNSWSDS------------LDLEIKQIQSDAYACSLIRRTK 845
                   |.|:|| |..  .:.....||.:|            .|...::.:.......|:..:.
Zfish   799 SGSCSSTSDSANTPWNTGGRESEHPPSWGESTPDDYRYANQTYTDPREREKEQHDMNKRLLDPSN 863

  Fly   846 MPLFDQFKRAYAEILFGWQLLSKRALILKHTQNTPPPVQGVEFVTECRKCAKPKRTPKCEPCKRP 910
            ...||.||:.|.|||..|.:..|||.:||.....|.|.:|:||...|..|....|..:|..|||.
Zfish   864 SWQFDDFKKCYGEILHRWGMKDKRAEVLKFVSCPPEPHKGIEFGVYCCHCRSQARGTQCAVCKRF 928

  Fly   911 VLFCVLCRLPVKGAANACLACGHGGHIDHMMQWFEKHNVCAT-CGCKCLERTS 962
            ...|.:|.:.|:|::|.||:||||||..|||.||...:||.| |||.||::::
Zfish   929 TFQCSICHVAVRGSSNFCLSCGHGGHTSHMMDWFRSQDVCPTGCGCHCLQQST 981

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr59	NP_609485.4	WD40	<92..343	CDD:225201	113/252 (45%)
		WD40 repeat	132..170	CDD:293791	14/37 (38%)
		WD40 repeat	178..213	CDD:293791	16/34 (47%)
		WD40 repeat	220..259	CDD:293791	14/38 (37%)
		WD40 repeat	263..306	CDD:293791	24/42 (57%)
		WD40 repeat	312..341	CDD:293791	15/28 (54%)
		mRING-H2-C3H3C2_WDR59	912..957	CDD:319606	24/45 (53%)
		modified RING-H2 finger (C3H3C2-type)	914..953	CDD:319606	21/39 (54%)
wdr59	XP_009291658.1	WD40	<34..314	CDD:225201	122/284 (43%)
		WD40 repeat	62..103	CDD:293791	10/42 (24%)
		WD40	97..>325	CDD:295369	111/234 (47%)
		WD40 repeat	109..150	CDD:293791	17/42 (40%)
		WD40 repeat	154..187	CDD:293791	15/32 (47%)
		WD40 repeat	195..229	CDD:293791	13/33 (39%)
		WD40 repeat	237..279	CDD:293791	24/42 (57%)
		RWD	<418..484	CDD:295432	26/66 (39%)
		Zn_ribbon_17	932..980	CDD:305234	26/47 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574538
Domainoid	1	1.000	272	1.000	Domainoid score	I1769
eggNOG	1	0.900	-	-		E2759_KOG0309
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	500	1.000	Inparanoid score	I1332
OMA	1	1.010	-	-		QHG45574
OrthoDB	1	1.010	-	-		D146113at33208
OrthoFinder	1	1.000	-	-		FOG0005787
OrthoInspector	1	1.000	-	-		oto39963
orthoMCL	1	0.900	-	-		OOG6_104242
Panther	1	1.100	-	-	LDO	PTHR46170
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1668
SonicParanoid	1	1.000	-	-		X4177
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800