Protein Alignment Wdr59 and wdr59

DIOPT Version :10

• Sequence 1: NP_609485.4
• Gene: Wdr59 / 34540
• FlyBaseID: FBgn0032339
• Length: 969
• Species: Drosophila melanogaster
• Sequence 2: XP_009291658.1
• Gene: wdr59 / 103909113
• ZFINID: ZDB-GENE-120215-187
• Length: 982
• Species: Danio rerio
• Alignment Length: 1028
• Identity: 341/1028 - (33%)
• Similarity: 511/1028 - (49%)
• Gaps: 153/1028 - (14%)

  Fly    33 NKYYEHRDSQATAMSVDYSGQWVLLAGRGHLALQRLGQDDGSLRRHERQSKYEVSVAEFAICPSR 97
            |...|.||:||.|||||..||..:|:||..|.:..|.....:.|:..||||::|...::....|.
Zfish     9 NVVVEFRDAQANAMSVDCLGQHAVLSGRRFLYVVNLETPSEAPRKISRQSKWDVGTVQWNPHKSD 73

  Fly    98 KEYCAIATSQHIDIVRW--GTAEPHYEMSLRGHTRTVTDIDWHGKDPNLLVSCSIDTFSHIWDLR 160
            ....|.:::|.:|:..|  |:.:.|  .||:||||.::|:||...:|..||:.|:||:.:|||..
Zfish    74 AHIFAASSNQRVDLYTWRDGSGKSH--TSLQGHTRVISDLDWSWFEPEFLVTSSVDTYIYIWDTS 136

  Fly   161 EPRKPALSLNAVCMSGATQVGFNRVSGNLLAAAHDGDLRIWDIRKGSCPTHYITAHLNRVHGINW 225
            :.|:|.::|:||  :||:||.:||.:...||::||||:||||.||.:....|:.|||::::|::|
Zfish   137 DTRRPTVTLSAV--AGASQVKWNRRNHYCLASSHDGDVRIWDKRKSNTAVEYVAAHLSKINGLDW 199

  Fly   226 SHKRETCLATASQDGTVKYFDVCNPRRAEKIITTMSPVWRARYTPIGNGLVSIVVPHLGRGENSL 290
            ....|..|||:|||.:|:::|...||:...|::...|||:|||||..||||:::||.| |.||||
Zfish   200 HPDNEYILATSSQDNSVRFWDYRQPRKYLDILSCQVPVWKARYTPFSNGLVTVMVPQL-RRENSL 263

  Fly   291 LLWSNSKQTDPICSFVGHTDVILDFAWRPNRESSNEIELVTWSRDRTLRVWKIDDNMLKLCEPSA 355
            ||||..:...|:.:||||.||:.:|.|||.:|.|.:.:|||.|||:|||:|::|..:.|||  .|
Zfish   264 LLWSTLELNSPVHAFVGHDDVVYEFQWRPQKEGSKDCQLVTLSRDQTLRIWRVDPQLQKLC--CA 326

  Fly   356 EEIESRFEPDLSELRVPTPPEFLHPRSILVAASLPISTGDGACNTLPMARSPSFGGGYYRREEPH 420
            .||       :.||...|........|     ..|:|.|..|.|:|.....|..|
Zfish   327 NEI-------VDELTTETEKTLRSQDS-----EPPLSPGFTADNSLDQFDGPQSG---------- 369

  Fly   421 IARSLTDQPTCSLHHEFSLLNTNMPHVEVDTLDAIKRYACF-KICAGGHTVILQVTFTTSYPSPS 484
            ::.|..:....:|..||||:|..:.:|.|: :||:.| :|| ....|.:.|.|.|.|...||: :
Zfish   370 LSSSAKNDIPQTLQQEFSLVNLQIRNVNVE-MDAVNR-SCFVSADCGANRVRLVVKFPAQYPN-N 431

  Fly   485 APPDFQLCQGTTLSSEVSGVLLKVLRCNALQRVKKSRTCLEQCLRALVAAMKKKVAAVGGADRSQ 549
            |.|.||....|.:||.:...:.|:|...:||:||:::.|||.|:|.||:.::.......|::...
Zfish   432 AAPSFQFVPPTNISSSMKIKIQKILTDTSLQKVKRNQNCLEPCVRQLVSCLESDGVMEDGSNPYV 496

  Fly   550 L-------LLQSPRLEGALSSTLHDACIPYPRTSGVHFNAIGMLTTFAQPVNNKRLTLRQHTALT 607
            |       |...||:.....| ..||.||:|||||..|...|.|..|.:|:...|.|  ..|..|
Zfish   497 LTNPVTPALPAFPRVTNTYGS-YQDANIPFPRTSGARFCGTGSLVYFTRPMTMHRAT--PPTEPT 558

  Fly   608 PRTFSSING--SGLL-----------------GNVMATAQREAN-ASFYLQERMISGKP------ 646
            ||:.|:::.  ||::                 |:...|.:.:.: :|||.:||    ||
Zfish   559 PRSLSALSAYHSGVMTPMKMRTESQTTLRLYSGSPTRTDKDQVSISSFYYKER----KPLSAARR 619

  Fly   647 ----------------GKQRAIRQMNGSPV-----VHVYDTSSLLHISRRMAREFSLDKCNIAET 690
                            ||:.. ...:..|:     |.:.:.|.||.:.:.:...:.|:..:|.:|
Zfish   620 WSVQTIHECPKSRRWKGKREG-GDYSNRPIKLAGKVIIQEISCLLSVHKALGETYVLNVNDIQDT 683

  Fly   691 CRKNGEICRQHGRLDLVPVWLLAEL-------------IATPQIPHETLNDLLFYKDPFKKSLLE 742
            |:|||.......|.||..||.||..             ..||...|           ||.:.|||
Zfish   684 CQKNGAAALAVARRDLAKVWALASASTNLNLSPDPDPDAGTPWAKH-----------PFGRHLLE 737

  Fly   743 SLIMHYAISGDIQTAVLLACLFDKCPTGGGAIMEKTVRLPPQ--LNSQISPYHTVLPLDVKS--- 802
            :|:.||:...|:|:..:|..:|    .|.|:..|.......|  ..:..:|:|:..|....|
Zfish   738 TLLEHYSQLSDVQSLAMLCSVF----RGHGSPQEYFTLYGHQQPRPAVFTPHHSRYPSFTSSSVT 798

  Fly   803 -------SSSSNT-WQQ--LKQLRSNSWSDS------------LDLEIKQIQSDAYACSLIRRTK 845
                   |.|:|| |..  .:.....||.:|            .|...::.:.......|:..:.
Zfish   799 SGSCSSTSDSANTPWNTGGRESEHPPSWGESTPDDYRYANQTYTDPREREKEQHDMNKRLLDPSN 863

  Fly   846 MPLFDQFKRAYAEILFGWQLLSKRALILKHTQNTPPPVQGVEFVTECRKCAKPKRTPKCEPCKRP 910
            ...||.||:.|.|||..|.:..|||.:||.....|.|.:|:||...|..|....|..:|..|||.
Zfish   864 SWQFDDFKKCYGEILHRWGMKDKRAEVLKFVSCPPEPHKGIEFGVYCCHCRSQARGTQCAVCKRF 928

  Fly   911 VLFCVLCRLPVKGAANACLACGHGGHIDHMMQWFEKHNVCAT-CGCKCLERTS 962
            ...|.:|.:.|:|::|.||:||||||..|||.||...:||.| |||.||::::
Zfish   929 TFQCSICHVAVRGSSNFCLSCGHGGHTSHMMDWFRSQDVCPTGCGCHCLQQST 981

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wdr59	NP_609485.4	WD40	<47..345	CDD:441893	129/299 (43%)
		WD40 repeat	132..170	CDD:293791	14/37 (38%)
		WD40 repeat	178..213	CDD:293791	16/34 (47%)
		WD40 repeat	220..259	CDD:293791	14/38 (37%)
		WD40 repeat	263..306	CDD:293791	24/42 (57%)
		WD40 repeat	312..341	CDD:293791	15/28 (54%)
		mRING-H2-C3H3C2_WDR59	912..957	CDD:438353	24/45 (53%)
wdr59	XP_009291658.1	WD40	<31..317	CDD:441893	124/290 (43%)
		WD40 repeat	62..103	CDD:293791	10/42 (24%)
		WD40 repeat	109..150	CDD:293791	17/42 (40%)
		WD40 repeat	154..187	CDD:293791	15/32 (47%)
		WD40 repeat	195..229	CDD:293791	13/33 (39%)
		WD40 repeat	237..279	CDD:293791	24/42 (57%)
		RWD	<418..484	CDD:413438	26/66 (39%)
		mRING-H2-C3H3C2_WDR59	930..976	CDD:438353	24/45 (53%)