DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16854 and R03G8.1

DIOPT Version :9

Sequence 1:	NP_001245974.1	Gene:	CG16854 / 34539	FlyBaseID:	FBgn0032338	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_510172.2	Gene:	R03G8.1 / 187544	WormBaseID:	WBGene00010996	Length:	663	Species:	Caenorhabditis elegans

Alignment Length:	779	Identity:	169/779 - (21%)
Similarity:	290/779 - (37%)	Gaps:	233/779 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LLDPKFMTKRDLQQYYRYYNMNKNRGQFKKVVIVIFALCVFSYLCVDYNLRTKLLRFRDGFDFMA 87
            ::||..:.|       |:|.:        ..::.|.....|:| .|...:.|         |:.|
Worm     1 MIDPYPLVK-------RFYEL--------PWILYILVCIAFTY-SVSIVIHT---------DYAA 40

  Fly    88 RI-EDHYGGNVTTAYFVDTTGCRMPHFEVSDDTIAQFIFKPRPYSCNRALIRTSDTIPGQLHLNL 151
            .: ||...||..     ||  |.:|.::|.|:.:..::      :.|...::..||....| ..|
Worm    41 PVTEDILVGNSW-----DT--CELPRYDVWDEELFGYL------NPNENPLKKCDTSFKPL-TKL 91

  Fly   152 EASELLAYYNISDLSSVNCNYTEVKRKTDSSN-----THSPAVSFKLDKVMKLPLSSEFICMWCY 211
            |.|:    :.::...::.|......||.|..|     |::|.           .::.|.:...|.
Worm    92 ENSK----WGVTFAHNLTCRARCHTRKRDKENLVGNWTYTPG-----------KINCEILETVCA 141

  Fly   212 D--SLDKLFYKDCHFFAV-DKPRIRPPLKTGTDRVSFNKSKEEQERLSVMILGMDSLSHLNFLRQ 273
            :  ...:..|...|...: .||::             :::..:.:...|.::.:||||:....|.
Worm   142 EKGGEQRDVYGYLHSQIIPTKPKL-------------SRTNADLKEYDVFVILLDSLSYSQAARS 193

  Fly   274 MRRTANYVRKHLSHVEFWGYNKVGDNTFPNLVPLLSGLDDQELNLACTPKTLRSYDRCSF----- 333
            :.||.::.:.::..:.|...||||||:.||.|.|..|            |.|...||..|
Worm   194 LPRTVSFFKSYMKGIIFPYMNKVGDNSRPNGVALWFG------------KLLEKVDRFIFDKPSL 246

  Fly   334 -------------------IWKRYQQLGYRSIFAEDVAMLSAFNYNQNGFRKQPTDYYLRPMIME 379
                               ::..::..||:::.|||.|:.:....|..|:|.|..|:|:||..:.
Worm   247 EADWTDDYFCNVFKDNETSLFDEFKTHGYKTLMAEDWALGTLIWPNCLGYRNQSIDHYMRPFQLA 311

  Fly   380 MEK--TVAFKKDLNMHLCMGSRRTADVLLEYMKKLV-----------------PRMSRDLYFSFF 425
            .||  |...::.||..||   |...:.||:|:.:.:                 |.......|:|.
Worm   312 HEKYGTPVTREHLNGSLC---REDHNTLLDYLAQFLDAYSGSNDSIQLKREKSPNSPDQRKFAFL 373

  Fly   426 WTVALTH---------------DYFNFPSLLDEAMLQQLMQLQDSGLLNRTVVMLLSDHGLRWGS 475
            ||..|.|               |:.||       .::...:|:||      .|:||.|||.|.|.
Worm   374 WTTRLGHATENGFDATENGSDNDFLNF-------FIKHRKKLEDS------FVLLLGDHGFRLGG 425

  Fly   476 FRRTYQGMMEERQPLMMLLYPPWMTERYPEAIANLRLNARRLTTPFDVHATMLQLLNLHNLEADQ 540
            .|.|..|.::...||..:..|..:... .:.:..|.:|:.:|.|.||..||:|.:|.....|.
Worm   426 VRNTAVGAIDVNNPLTAISVPNSLRTN-TDILKILNMNSEKLQTHFDTRATILDILKFQPAEK-- 487

  Fly   541 LQRRSTEMDEPDSTLPRGISLFLPI---------------PAARTCEQAGIAAHWCTCHQRQELQ 590
                              .|...|:               |..|.|:...|...:|.|      |
Worm   488 ------------------FSAITPLQIPGEKGQSHLRNQPPFNRNCQTMPIPFEYCIC------Q 528

  Fly   591 TNDPRV-----------QRAARYLVRL--INNRLKDSSQCRTLYL---NSILQALIAAPHSKIVK 639
            .|...|           ::.|..:.:|  |||   .:|:|.::..   .|:||      :::.:.
Worm   529 FNKTSVPINSTISMEIGEKVAENVNKLLQINN---FTSECISMVFERTESLLQ------YNQKLG 584

  Fly   640 NISTDYAVDITLRLQTKPGLGVFESTVRMTGYTTVLTGTISRLNLYGSQSYCLNDPALKMFCYC 703
            | ||.|.|...::   ||....|::||::|.....:...:.|::.||..:.|:.....:..|||
Worm   585 N-STIYTVIAQMK---KPSEAKFKATVKITEGNIKIVSKVERVDSYGKTADCIESETHRPICYC 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16854	NP_001245974.1	DUF229	126..626	CDD:281053	127/596 (21%)
CG16854	NP_001245974.1	ALP_like	255..533	CDD:293745	87/335 (26%)
R03G8.1	NP_510172.2	DUF229	74..651	CDD:281053	147/668 (22%)
R03G8.1	NP_510172.2	ALP_like	175..483	CDD:293745	87/336 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28588
OrthoDB	1	1.010	-	-		D306348at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10974
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.990