DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16854 and F15H10.7

DIOPT Version :9

Sequence 1:	NP_001245974.1	Gene:	CG16854 / 34539	FlyBaseID:	FBgn0032338	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_505674.1	Gene:	F15H10.7 / 184555	WormBaseID:	WBGene00008874	Length:	666	Species:	Caenorhabditis elegans

Alignment Length:	710	Identity:	166/710 - (23%)
Similarity:	315/710 - (44%)	Gaps:	108/710 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 YYNMNKNRGQFKKVVIVIFALCVFSYLCVDYNLRTKLLRFRDGFDFMARIEDHYGGNVTTAYFV- 103
            :||.:.....:.||.: ||.:|...|    |.|      ||...||.           |..:|:
Worm     7 FYNYSHYITYYSKVAL-IFVICFGVY----YGL------FRTETDFS-----------THPHFLY 49

  Fly   104 --------DTTGCRMPHFEVSDDTIAQFIFKPRPYSCNRALIRTSDTIPGQLHLNLEASELLAYY 160
                    ..:.|.:|..:..|.:|..:..||.|..|:...::...:....: |..|...
Worm    50 LQKLRDSQSKSECVIPDADPWDPSILSYYSKPSPLVCSTMQVQAVKSFNNGI-LTFEPQV----- 108

  Fly   161 NISDLSSVNCNYTEVKRK---TDSSNTHSPAVSFKLDKVMKLPLSSEFICMWC-YDSLDKLFYKD 221
                :.:..|..|.::..   ||....:...|...|.....:.:|.|...:.| .|:|.|
Worm   109 ----IKNARCYKTGIRHDENVTDLDVIYEKPVPLNLTHTSSIKISDEVFQITCESDNLLK----- 164

  Fly   222 CHFFAVDKPRIRPPLKTGTDRVSFNKSKEEQERLSVMILGMDSLSHLNFLRQMRRTANYVRKHLS 286
            ...|.....:|.|......::|.   .:...:..||:::|:||:|..||:|||::|..|: |...
Worm   165 SEIFKYHYTQIVPKSSNIKNKVI---EQSTSDFPSVIMIGLDSMSRGNFVRQMQKTYKYM-KEAG 225

  Fly   287 HVEFWGYNKVGDNTFPNLVPLLS---GLDDQELNLACTPKTLRSYDRCSFIWKRYQQLGYRSIFA 348
            .::..|:.|:.|||:.||:.:|:   |:..:|.:.........::|...||||.:...||.::||
Worm   226 FIDMEGHMKIHDNTYGNLLAILTGKRGVGVKEFSTEINESWHIAFDEFDFIWKTFSDNGYATLFA 290

  Fly   349 EDVAMLSAFNYNQ--NGFRKQPTDYYLRPMIMEMEKTVAFKKDLNMHLCMGSRRTADVLLEYMKK 411
            ||...:..|.|..  .||.|||||:|:||..:....::..::  ::..|..|.....:.|:|:::
Worm   291 EDRPDIGTFTYKNMLEGFLKQPTDHYIRPFWISAFWSLISRR--SVASCYDSTPQHKIQLKYLEE 353

  Fly   412 LVPRMSRDLYFSFFWTVALTHDYFNFPSLLDE----AMLQQLMQLQDSGLLNRTVVMLLSDHGLR 472
            .:.:..:...|:|:|:..::|.:.|....:|:    .......:::||      ::::.||||.|
Worm   354 FLEKYDKKRKFAFWWSQDMSHGFLNLIGKVDDDFEKFFKNNEKRMEDS------IIIVFSDHGHR 412

  Fly   473 WGSFRRTYQGMMEERQPLMMLLYPPWMTERYPEAIANLRLNARRLTTPFDVHATMLQLLNLHNLE 537
            :...|.|..|.:|.|.|...:..|..:.::||:.:.||.:|::.:||.|||:.      :|..:.
Worm   413 YDKIRETVIGRIESRMPFHSIRIPDGIKKKYPQIVENLMVNSKLMTTQFDVND------SLRKIA 471

  Fly   538 ADQLQRRSTEMDEPDSTLPRGISLFLPIPAARTCEQAGIAAHWCTCHQRQELQTNDPRVQRAARY 602
            ..::..:.|:.|.     .|..|.|.|.|....|.:|||.:.:|.|....|:..::  .:.||..
Worm   472 TGKVGEKWTQTDR-----KRSYSYFDPFPKRIGCYEAGIPSDFCPCFSEIEIPKSE--AKEAAVE 529

  Fly   603 LVRLINNRLKDSSQ---------------CRTLYLNSILQALIAAPHSKIVKNISTD------YA 646
            |:|::|:.|:::.:               |..:.:.::..:.:..|...::|::.::      ::
Worm   530 LMRIVNDLLENTEKTEEYEPDSKELTEYMCTPMEIQNVEFSSVRLPMLSVLKDVKSEDTPLQSFS 594

  Fly   647 VDITLRLQTK-PGLGVFESTVRMTGYTTVLT--GTISRLNLYGSQSYCLNDPALKMFCYC 703
            :...:.::.| |...:.|||:.....|...:  |.:.|.|.||:.|:|:||..||..|:|
Worm   595 LQYHVVVRAKAPSNALLESTLEHNLKTNTWSSLGEVERNNKYGNTSFCVNDRILKKICHC 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16854	NP_001245974.1	DUF229	126..626	CDD:281053	125/527 (24%)
CG16854	NP_001245974.1	ALP_like	255..533	CDD:293745	81/286 (28%)
F15H10.7	NP_505674.1	DUF229	79..568	CDD:281053	125/528 (24%)
F15H10.7	NP_505674.1	ALP_like	195..472	CDD:293745	82/291 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162109
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28JJT
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28588
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm4742
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.710