DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16854 and Y41E3.1

DIOPT Version :9

Sequence 1:	NP_001245974.1	Gene:	CG16854 / 34539	FlyBaseID:	FBgn0032338	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_001041024.1	Gene:	Y41E3.1 / 178413	WormBaseID:	WBGene00012762	Length:	682	Species:	Caenorhabditis elegans

Alignment Length:	720	Identity:	204/720 - (28%)
Similarity:	324/720 - (45%)	Gaps:	124/720 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 VIFALCVFSYLCVDYNLRTKLLRFRDGFDFMARIE------------------------DHYGGN 96
            :|.||||..|..        |...|.|:|.::|:|                        |.:.|.
Worm    13 IIGALCVSVYFV--------LSTLRIGYDDVSRLEQSRAERYQEIDEIPVKVRTVHSDRDRHKGE 69

  Fly    97 VTTAYFVDTT----GCRMPHFEVSDDTIAQFIFKPRPYSCNRALIRTSDTIPGQ-LHLNLEASEL 156
            .::....:|.    .|.:|..|::...:..|.....|..|.:     .::|... :.:|.||  :
Worm    70 DSSEKHAETALQSQKCNIPKLEINGSEVINFFKTHAPLECQK-----KNSIEDNWVFINDEA--I 127

  Fly   157 LAYYNISDLSSVNCNYTEVKRKTDSSNTHSPAVSFKLDKVMKLPLSSEFICMWCYDSLDKLFYKD 221
            :.:  ....:...|......|..|::|.:...|.......|.   .|::..:.|.....|  :|.
Worm   128 IRF--TEKRAKAKCKIQYFSRVDDNNNKYEEPVEVLDGDRMN---GSDYATISCIQGFQK--WKS 185

  Fly   222 CHFFAVDKPRIRPPLKTGTDRVSFNKSKEEQERLSVMILGMDSLSHLNFLRQMRRTANYVRKHLS 286
            ..:...|:|.|....:    ::...::..|::..:|..||.||||.::|.|::.:|..::.:.|.
Worm   186 ILWDVNDEPEIHERAR----KMRKEQADPEKKPYNVYFLGFDSLSQMSFRRKLPQTVKFLEETLG 246

  Fly   287 HVEFWGYNKVGDNTFPNLVPLLSGLDDQELNLACTPKTLRSY-------DRCSFIWKRYQQLGYR 344
            .|...|||.|||.|....:|:|:...:.||     |.|.:.|       |...||||.|...||.
Worm   247 SVVLNGYNIVGDGTPQAFIPILTAQTETEL-----PLTRKRYKNANYVDDVYPFIWKNYSDKGYV 306

  Fly   345 SIFAEDVAMLSAFNYNQNGFRKQPTDYYLRPMIMEMEKTVAFKKDLNMHLCMGSRRTADVLL--- 406
            :::|||...:..|.|...|||:||||:|.|.:..|:||       ||...|:||.....:.|
Worm   307 TMYAEDAFSIGTFTYRLKGFRQQPTDHYTRTLFEEVEK-------LNDRNCIGSIPLHRMWLQNG 364

  Fly   407 -EYMKKL--VPRMSRDLYFSFFWTVALTHDYFNFPSLLDEAMLQQLMQLQDSGLLNRTVVMLLSD 468
             ::|||.  |||      |.......|:||..|...:.||.:...|..:.|.||.:.:||::::|
Worm   365 RQFMKKYEDVPR------FLLMHQSLLSHDDINLVGVEDEDLSAHLSHMNDEGLFDDSVVIVMAD 423

  Fly   469 HGLRWGSFRRTYQGMMEERQPLMMLLYPPWM--TERYPEAIANLRLNARRLTTPFDVHATMLQLL 531
            ||.|:...|.|:||.:|||.|...:..|..:  ||:..:...|||.||.:||:|||:||:::.:|
Worm   424 HGHRFAKLRDTHQGQLEERMPFFSISLPKQLRNTEKGRKMEQNLRENAEKLTSPFDIHASLMDIL 488

  Fly   532 NLHNLEADQLQRRSTEMDEPDSTLPRGISLFLPIPAARTCEQAGIAAHWCTC-HQRQELQTNDPR 595
            ||..|..::|.|..      |::..|.:|:|.|||..|||.||||..||||| ..:..:.|.:.|
Worm   489 NLSELGENELNRMQ------DASSKRSLSVFKPIPVDRTCSQAGIEPHWCTCLSWKDAMDTGEDR 547

  Fly   596 --VQRAARYLVRLINNRL-KDSSQCRTLYLNSILQALIAAPHSKIV--KNI--STDYAVDIT--- 650
              .:|.|..:||.||..: .:...|..|.|..|:.|....|...::  ||:  :..:..|::
Worm   548 KLTRRIANAVVREINKEIVAEKDLCAPLSLAKIIDAKKLLPDKGLLAYKNVKDADGFVPDLSGST 612

  Fly   651 --------LRLQTKPGLGVFESTVRMTGYTTVLT------GTISRLNLYGSQSYCLNDP--ALKM 699
                    |:|||.||..::|.|:   .|..|..      |::|.:|.:|...:|:.|.  .|..
Worm   613 KAAFAHYQLKLQTTPGEAIYEVTL---FYDIVRDEVKLDFGSMSHVNKFGDTPHCIIDKNYYLAT 674

  Fly   700 FCYCH 704
            ||.|:
Worm   675 FCVCY 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16854	NP_001245974.1	DUF229	126..626	CDD:281053	159/519 (31%)
CG16854	NP_001245974.1	ALP_like	255..533	CDD:293745	104/292 (36%)
Y41E3.1	NP_001041024.1	DUF229	78..581	CDD:281053	164/544 (30%)
Y41E3.1	NP_001041024.1	ALP_like	215..491	CDD:293745	105/293 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162103
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840