DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Samuel and samd11

DIOPT Version :9

Sequence 1:	NP_001260372.1	Gene:	Samuel / 34530	FlyBaseID:	FBgn0032330	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	XP_009295182.1	Gene:	samd11 / 569122	ZFINID:	ZDB-GENE-060428-2	Length:	874	Species:	Danio rerio

Alignment Length:	780	Identity:	171/780 - (21%)
Similarity:	270/780 - (34%)	Gaps:	251/780 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   316 PSGPSMATATTTSSLSSSSSASASASASASAATHMPLHNLSTNLLNSIQQAAASQQQLRSSNSNS 380
            |..|:.......:|:.||..:..|..||...|              .|:|...:...:|.|..:.
Zfish   195 PLPPTRVPKKELASVFSSDDSEGSERASGDHA--------------DIKQEELNFTIMRKSRDSD 245

  Fly   381 SSNISGSSNNTKSDG---GAASNATDFSTRNYSDIM---RCLAAKYNNANPNDNNATRRNSYYDG 439
            .|.|..:.::|:..|   |.:.:....::.:..||:   |..:...::..|:|:..:|..|..:.
Zfish   246 LSTIISNLHHTRQHGMPEGQSCSDLSLASAHTDDILGKRRAYSPNSSSECPSDSKKSRSVSPKEN 310

  Fly   440 STSATTATGGAGGGGGGAGGSNSAPSS---ALKTASSSTGSTTTTAKKLSPSAASAANSAAV--- 498
            |.:.....           ||:..|..   .:.:|.:..||.....::|    ...||:..:
Zfish   311 SHTPALEP-----------GSHMTPEEHYRRMMSALNEHGSYEEQQQRL----YQLANNMGIPSH 360

  Fly   499 ---SLSKESKVSAVGGAGVGGAVASSGGGGSSMSQ------------------LAPPPTAPSPTE 542
               .:.:|:.|:.....|:...|.|:   |||.||                  ::.||...||
Zfish   361 ELLHVRQEAMVAVRNPGGMEAHVPSA---GSSSSQRRKQGLPQHRDAHFPERDISHPPPLLSP-- 420

  Fly   543 QAKSQMAAVVAAASVSPFMTNFLPFSSGIFPPLIDMSST--QA----LLTLARAVKDAEIQEILR 601
                |.|..:|   :.|.:.          ||.:.|.|.  ||    .|..|:|...|..|||||
Zfish   421 ----QNAPHIA---LGPHLR----------PPFLGMPSALCQAPGYGFLQPAQAEMFARQQEILR 468

  Fly   602 SK------------QQRSGSN------ASSPSASAAGTPRSSSTL-------------------N 629
            .:            :|:...|      .:.|.....|.|.....|                   |
Zfish   469 KQNLARLEMSAELLRQKELENLHRQRLLADPLGLHPGLPAEHPALRSLQEIPEGHPLREELNRRN 533

  Fly   630 AAL-------------HQAAQFVTPALIYSAQLQQQQQQQQQQHQRQQQQQSQHASRQSSPRST- 680
            |.|             ||.|...|.:...|.:...::....|..|:....:::...|:...|..
Zfish   534 AMLVLRHNNTPLLSLNHQGAAAGTSSKDLSNRKSLRKGGPLQGDQQGGSSETKEMLREGCVRDVE 598

  Fly   681 --------NDSTTVAPIGDG-------GGGSSIAS--AAPLDLSSQPPAAKRFKAERRASSTATT 728
                    .||...|.:|:.       |.|..::|  ....|::....|.|    |....|...:
Zfish   599 TEGMDEDMKDSENDAEVGEDRPERLSKGDGHGLSSEVCQGKDVTKTSEAIK----ELGEGSGRLS 659

  Fly   729 ATTATTGSSTST-----------------PSPPPLEQHDDINSGNANATLGTRSG---------- 766
            ...::||..:.|                 |..|||.               |..|
Zfish   660 VPCSSTGQESPTHHLFTSGLGKNEAKYLPPGIPPLP---------------TLPGQMLPFTFPYS 709

  Fly   767 -----TGT-GESSAAGSGAGVAKARRRCQAQSEEVNSWSVDDVCGFVGGIDICAEYVQSFRDQSI 825
                 ||. |.....|..||.|          |:::.|||::||.|:..:..|.||.|.||:|:|
Zfish   710 SPYFHTGAMGGLFVDGEEAGAA----------EDISKWSVEEVCSFISSLAGCGEYTQVFREQAI 764

  Fly   826 DGTGLPLLTEDHLVNSLGMKLGPALKLRSILAKKLGG-----------PCPCVACVAQAQQMLAL 879
            ||..|||||||||:|::|:|||||||:||.:|:::|.           |.|..|.....:..|..
Zfish   765 DGETLPLLTEDHLLNNMGLKLGPALKIRSQVARRIGRIFYMTSFPLALPLPPSALRPTDRDPLPT 829

  Fly   880 QTGGAAAATGATAGAGTVTGAVAGAGATSATTSCSIKSEIFNGGSNGSSSGSSSNQGSDVAAPPA 944
            :|  ...:|.:|:...:|           ...:|....:..||  |.||:|:     .|...||:
Zfish   830 ET--RPPSTSSTSSPFSV-----------PPPACRTSPKQENG--NPSSAGA-----YDSTKPPS 874

Fly 945 944
Zfish 875 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Samuel	NP_001260372.1	SAM_Samd7,11	795..862	CDD:188978	37/66 (56%)
Samuel	NP_001260372.1	SAM	795..852	CDD:197735	33/56 (59%)
samd11	XP_009295182.1	SAND	93..165	CDD:279658
		SAM_Samd7,11	734..801	CDD:188978	37/66 (56%)
		SAM	735..791	CDD:197735	33/55 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	81	1.000	Domainoid score	I8438
eggNOG	1	0.900	-	-		E1_KOG4333
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006289
OrthoInspector	1	1.000	-	-		otm24779
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12247
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5499
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.030