DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Samuel and deaf1

DIOPT Version :9

Sequence 1:	NP_001260372.1	Gene:	Samuel / 34530	FlyBaseID:	FBgn0032330	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	XP_005174312.1	Gene:	deaf1 / 563776	ZFINID:	ZDB-GENE-081022-163	Length:	532	Species:	Danio rerio

Alignment Length:	524	Identity:	104/524 - (19%)
Similarity:	176/524 - (33%)	Gaps:	124/524 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 PTTSQLSAPASSASSSSMSSSSAGSTCTTNANTASVAAAYAAFYLEKVKHEKMDNHKDA------ 203
            |.|.:|.  ...||.|:.:....||...:.|..|::.....|..::..  |.:.|..||
Zfish     7 PATKELE--LGDASESASTGEPVGSDTESEAEVATMTVMGEAGTIDIT--ESLPNPDDAETAFAE 67

  Fly   204 -PMVTIHNNNNNNTINNNNSSSSSSSSIINNHQSSQPSLGHSV--KRERLSPGSNSSSHNGELTV 265
             ..||:            ....||..|:..:..::..|:...|  .|..|..|:..|:....|.|
Zfish    68 VTAVTV------------GDVQSSDDSVFTSAVATATSIPEHVLTGRATLQIGNTLSTQKATLIV 120

  Fly   266 SSFARSRSATPSSSSYRGAGGGAGGGVSPSHQQQQQQQQQSLQQQQRLSPPSGPSMATATTTSSL 330
               ..:..:...::|.:..|                             .|..|...|..|..:.
Zfish   121 ---VHTDGSIVDATSLKATG-----------------------------TPMTPGPQTPNTPLAS 153

  Fly   331 SSSSSASASASASASAATHMPL--HNLSTNLLNSIQQAAASQQQLRSSNS-NSSSNISGSSNNTK 392
            ......|......:.....:|:  .|.|..|..:...:....:.::.:|| .:.:...|.|
Zfish   154 GHDKDVSKYNWDPSVYDNELPVRCRNTSGLLYKNRLGSGGKGRCIKHNNSWYTPTEFEGMS---- 214

  Fly   393 SDGGAASNATDFSTRNYSDIMRCLAAKYNNANPNDNNATRRNSYYDGSTSATTATGGAGGGGGGA 457
              |.|:|.....|.|.....::||..: ...||:..:.|......|.||.:.|.|      ..|:
Zfish   215 --GRASSKDWKRSIRYAGRPLQCLIQE-RILNPHAASCTCAACCDDLSTVSDTCT------KEGS 270

  Fly   458 GGSNSAPSSALKTASSSTGSTT-----TTAKKLSPSAASAANSAAVSLSKESKVSAVGGA----G 513
            .|..|.         |.||...     ...||.:..|||..|...:...|  .::...||    .
Zfish   271 YGQESL---------SMTGPVRLFVPYKRRKKDNERAASPDNKKEIQSPK--NITLAPGATFTVS 324

  Fly   514 VGGAVASSG-------GGGSSMSQLAPPPTAPS-----------PTEQAKSQMAAVVAAASVSPF 560
            ..|.:::||       ..|.:.|.::..|.||.           |......|.|.|.:....:..
Zfish   325 PSGQISTSGTLSFDRSASGETASIISDSPAAPDVYTNTTVLTTLPALAVVPQQAVVQSKPPPAGT 389

  Fly   561 MTNFLPFSSG---IFPPLIDMSSTQALLTLARAVKDAEIQEILRSKQ-QRSGSNAS-SPSASAAG 620
            :.|.|  .:|   .:..|.:|::|  ||:..:.:|..    |.::|| .:||::|: ||..:::|
Zfish   390 LLNGL--ETGEQRTWLYLEEMANT--LLSNVQQLKVL----IAQAKQASQSGAHATISPDKNSSG 446

  Fly   621 TPRS 624
            ...|
Zfish   447 RKES 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Samuel	NP_001260372.1	SAM_Samd7,11	795..862	CDD:188978
Samuel	NP_001260372.1	SAM	795..852	CDD:197735
deaf1	XP_005174312.1	SAND	168..242	CDD:279658	15/80 (19%)
deaf1	XP_005174312.1	zf-MYND	474..510	CDD:280009
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4333
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900