DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Samuel and phc1

DIOPT Version :9

Sequence 1:	NP_001260372.1	Gene:	Samuel / 34530	FlyBaseID:	FBgn0032330	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	XP_005158395.1	Gene:	phc1 / 403008	ZFINID:	ZDB-GENE-081022-39	Length:	901	Species:	Danio rerio

Alignment Length:	1025	Identity:	198/1025 - (19%)
Similarity:	306/1025 - (29%)	Gaps:	350/1025 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 AAQPATHDDQEAATTASTATKRKHLERLASDLRQLGKKGRRS-RSVSPCSRYPAVAETAR--MLS 104
            |.:..|:.....::.||....|      ...:.|:....|:: :::....|.|..|:..:  ||.
Zfish     3 AGEDQTNSSSTNSSAASGGNSR------PPQIAQMSLYERQAVQALQALQRQPNAAQYFQQLMLQ 61

  Fly   105 ERSLLLSGYGAIESSAKKLSEAATGGAGGGGGGAAGQAATPTTSQLSAPASSASSSSMSSSSAGS 169
            ::         |.|:..:|...|          |..||....:.|.|:|.:|||..:.|:.
Zfish    62 QQ---------INSATCQLHNLA----------AVQQATLAASRQSSSPNNSASQPTSSAQ---- 103

  Fly   170 TCTTNANTASVAAAYAAFYLEKVKHEKMDNHKDAPMVTIHNNNNNNTINNNNSSSSSSSSIINNH 234
             ||.|.:|.|...                        |:.|........:..|::.|.|.::..:
Zfish   104 -CTVNLSTTSAGG------------------------TMTNPRPIGPATSAASTALSQSVLLGGN 143

  Fly   235 QSSQPSLGHSVKRERLSPGSNSSSHNGELTVS-SFARSRSATPSSSSYRGAGGGAGGGVSPSHQQ 298
            ...|..:...|.|...:|          ||.. .|....:||.:.::           |:.:..|
Zfish   144 SGGQGQMYLRVNRSLRAP----------LTPQLIFMPGGTATATVAT-----------VAQTQPQ 187

  Fly   299 QQQQQQQSLQQQQRLSPPSGPSMATATTTSSLSSSSSASASASASASAATHMPLHNLSTNL--LN 361
            ||.|||...||||..:|.|..|.:......:|   :....|...:|:..|.......:|..  ||
Zfish   188 QQPQQQPQQQQQQEATPTSSSSQSDNDQVQNL---AMRCVSTPRAATVKTEFADRKETTGTFPLN 249

  Fly   362 -----------SIQQAAASQQQLRSSNSNSSSNISGSS---NNTK---------SDGGAASNATD 403
                       |.||.....|.|.::...|.||.:..|   .|.|         ...||:||...
Zfish   250 QQTQTPQQFGQSTQQVQPQTQPLANAKLQSFSNTANPSVPALNVKPTNQSAVAPQQAGASSNPPS 314

  Fly   404 FS---TRNYSDIMRCLAAKYNNANPNDNNATRRNSYYDGSTSATTATGGAGGGGGGAGGSNSAPS 465
            .|   :...|.::...:..:.......:.||..:.....|...|:..|              .|.
Zfish   315 SSPTPSLPLSQLLLSQSGLHQTRGVPGSTATVTHILVPTSNVPTSTQG--------------YPL 365

  Fly   466 SALKTASSSTGSTTTTAKKLSPSAASAANSAAVSLSKESKVSAVGGAGVGGAVASSGGGGSSMSQ 530
            ..:.|.|:.|..|..    :.|...:.||     ||.|......|...:....|........||.
Zfish   366 GTVATKSNMTAQTLV----VQPLQQTGAN-----LSTEKLAHGTGHVPIQPKTAQGHRVPVQMSP 421

  Fly   531 LAPPPTAPSPTEQAKSQMAAVVAAASVSPFMTNFLPFSSGIFPPLIDMSSTQALLTLARAVKDAE 595
            ..|||..|:|....::                     ::|:.||.:.:.     |..||......
Zfish   422 RHPPPILPAPPNNGQA---------------------TAGLHPPHVPVQ-----LVGARQSTLGN 460

  Fly   596 IQEILRSKQQRSGSNASSPSASAAGTPRSSSTLNAALH--------QAAQFVTPALIYSAQLQQQ 652
            .|.:..::.:...|.....:|.....|.:..|:..|:.        :.||...|.    :|:|..
Zfish   461 SQALALAQARTCCSQQDGTAAVGVNNPGNVVTMVTAMDTSGAGMCLKTAQSALPI----SQMQTN 521

  Fly   653 QQQQQQQ-------HQRQQQQQS------QHASRQSSP-------RSTNDST---TVAPIGDGGG 694
            |.....|       |....|..|      |.|..|..|       :|.:|.|   :..||  .|.
Zfish   522 QSAVLSQGNPASVTHSMDGQNNSGDSLFVQSAQAQIKPAIGPIKRKSESDLTHEISNEPI--SGS 584

  Fly   695 GSSIASAAPL----DLSSQPPAAKRFKAERRASSTATTATTATTGSSTSTPSP------------ 743
            .|...||.||    .|.:.|..|  |.:....|.:.........|.....|.|
Zfish   585 PSMQDSAPPLSPAPSLDTVPEIA--FSSPPTLSLSLPLPLPRGAGQGDRAPVPQAVVKPQVLTHL 647

  Fly   744 --------------------------PPLEQHDDINSGN---------ANATLGTRS-------- 765
                                      ||:...:||.|..         |.|:...||
Zfish   648 IEGFVIQEGAEPFPVTGPLKELSGAVPPILHPEDIRSDKLKCEYCLNFAPASQFRRSKRFCTISC 712

  Fly   766 ----------------GTGTGESSAAGSGAGVAKARRR----------------------CQAQ- 791
                            |....|..|.|.......||||                      |:::
Zfish   713 SKRYNVSFRNHLRASRGLEGAERPAGGPVVQDVIARRRAPRRSSSEIACAKITGRHLPVKCRSES 777

  Fly   792 --SEEVNS----------------------------------------------------WSVDD 802
              |::::|                                                    |||.:
Zfish   778 SRSDDISSCEGEEEEDFLSLSPSSTFSCPRPTHCGPQLDDTAPGGLPVDENHFLSGNPADWSVQE 842

  Fly   803 VCGFVGGIDICAEYVQSFRDQSIDGTGLPLLTEDHLVNSLGMKLGPALKL 852
            ||.|:..:..|.:....|..|.|||..|.||.|:||::::.:|||||||:
Zfish   843 VCQFISSLQGCEDLASQFLSQEIDGQALMLLKEEHLMSTMNIKLGPALKI 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Samuel	NP_001260372.1	SAM_Samd7,11	795..862	CDD:188978	26/110 (24%)
Samuel	NP_001260372.1	SAM	795..852	CDD:197735	25/108 (23%)
phc1	XP_005158395.1	PHC2_SAM_assoc	<763..832	CDD:293222	3/68 (4%)
		SAM_Ph1,2,3	834..901	CDD:188976	25/59 (42%)
		SAM	835..901	CDD:197735	25/58 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12247
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.100