DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Samuel and SAMD7

DIOPT Version :9

Sequence 1:	NP_001260372.1	Gene:	Samuel / 34530	FlyBaseID:	FBgn0032330	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	NP_001291295.1	Gene:	SAMD7 / 344658	HGNCID:	25394	Length:	446	Species:	Homo sapiens

Alignment Length:	405	Identity:	94/405 - (23%)
Similarity:	152/405 - (37%)	Gaps:	106/405 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   529 SQLAPP-------PTAPSPTEQAK----SQMAAVVAAASVSP--FMTNFLPFSS------GIFPP 574
            |...||       |:..:||:..:    ||.     .:||.|  .|.|.|  ||      ||.||
Human    20 SPFGPPTVDRDVLPSTVAPTDPRQFCVPSQF-----GSSVLPNTNMANVL--SSRIYPGWGILPP 77

  Fly   575 LIDMSSTQALLTLARAVKDAEIQ---------EILRSKQQRSGSNASSPSASAAGTP----RSSS 626
                   :::..:||  ::..||         |:....|||.....:....:..|.|    .|..
Human    78 -------ESIKAVAR--RNEMIQRHHTARTEMEMYAIYQQRRMEKINPKGLAGLGIPFLYGSSVP 133

  Fly   627 TLNAALHQAAQFVTPAL--------------IYSAQLQQQQQQQQQQHQRQQQQQSQHASRQSSP 677
            ...||.|..:......|              :.:|.....::...|:.:|.::......:..|..
Human   134 AAPAAYHGRSMLPAGDLHFHRSTLRNLQGNPMLAATAPHFEESWGQRCRRLRKNTGNQKALDSDA 198

  Fly   678 RSTNDSTTVAPIGDGGGGSSIASAAPL--DLSSQPPAAKRFKAERRASSTATTATTATT------ 734
            .|:........:|.       ..|.|.  |..::.|..:. .:.:::|.|....|||..
Human   199 ESSKSQAEEKILGQ-------THAVPYEEDHYAKDPDIEA-PSNQKSSETNEKPTTALANTCGEL 255

  Fly   735 --------GSSTSTPSPPPLEQHDDINSGNANATLGTRSGT----------GTGESSAAGSGAGV 781
                    ||.|:|......:...:..|....||...::|.          ||......|....:
Human   256 EPTHRKPWGSHTTTLKAKAWDDGKEEASEQIFATCDEKNGVCPPVPRPSLPGTHALVTIGGNLSL 320

  Fly   782 AKARRRCQAQSEEVNSWSVDDVCGFVGGIDICAEYVQSFRDQSIDGTGLPLLTEDHLVNSLGMKL 846
                      .|::..|:||||..|:..:..|::|.|.|:|.:|||..||||||:||..::|:||
Human   321 ----------DEDIQKWTVDDVHSFIRSLPGCSDYAQVFKDHAIDGETLPLLTEEHLRGTMGLKL 375

  Fly   847 GPALKLRSILAKKLG 861
            |||||::|.:::.:|
Human   376 GPALKIQSQVSQHVG 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Samuel	NP_001260372.1	SAM_Samd7,11	795..862	CDD:188978	32/67 (48%)
Samuel	NP_001260372.1	SAM	795..852	CDD:197735	29/56 (52%)
SAMD7	NP_001291295.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	187..207		2/19 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	225..277		10/52 (19%)
		SAM_Samd7,11	324..391	CDD:188978	32/67 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	83	1.000	Domainoid score	I8358
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41156
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12247
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.100