DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Samuel and ph-p

DIOPT Version :9

Sequence 1:	NP_001260372.1	Gene:	Samuel / 34530	FlyBaseID:	FBgn0032330	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	NP_476871.2	Gene:	ph-p / 31181	FlyBaseID:	FBgn0004861	Length:	1589	Species:	Drosophila melanogaster

Alignment Length:	1103	Identity:	222/1103 - (20%)
Similarity:	370/1103 - (33%)	Gaps:	357/1103 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 QKPAKATTAIVGGRSAAQP----------ATHDDQEAATTASTATKRKHLERL-ASDLRQLG--- 78
            |.|.||.|.:    .|..|          .|:..|:.....:||..::..::| |:.|::.|
  Fly   603 QTPTKARTQL----DALAPKQQQQQQQVGTTNQTQQQQLAVATAQLQQQQQQLTAAALQRPGAPV 663

  Fly    79 --KKGRRSRSVSPCSRYPAVAET---ARMLSERSLLLSGYGAIESSAKKLSEAATGGAGGGGGGA 138
              ..|.:.|..|..|...|..::   |:|.:::..:......:::..               |..
  Fly   664 MPHNGTQVRPASSVSTQTAQNQSLLKAKMRNKQQPVRPALATLKTEI---------------GQV 713

  Fly   139 AGQ---AATPTTSQLSAPAS------SASSSSMSSSSAGSTCTTNANTASVAAAYAA-------- 186
            |||   ....||.|....|:      :|:.:.|...|...|..|..|..::.||.||
  Fly   714 AGQNKVVGHLTTVQQQQQATNLQQVVNAAGNKMVVMSTTGTPITLQNGQTLHAATAAGVDKQQQQ 778

  Fly   187 ---FYLEKVKHEKMDNHKDAPMVTIHNNNNNNTINNNNSSSSSSSSIINNHQ-----SSQPSLGH 243
               |..:::..::....:....:.:.................|....:|..|     ..|.::..
  Fly   779 LQLFQKQQILQQQQMLQQQIAAIQMQQQQAAVQAQQQQQQQVSQQQQVNAQQQQAVAQQQQAVAQ 843

  Fly   244 S--VKRERLSPGSNSSSHNGELTVSSFARSRSATPSSSSYRGAGGGAGGGVSPSHQQQQQQQ--- 303
            :  .:||:....:.:.:.:.:...::..:.....|:.             ...|||||||||
  Fly   844 AQQQQREQQQQVAQAQAQHQQALANATQQILQVAPNQ-------------FITSHQQQQQQQLHN 895

  Fly   304 -------------------------------------------------QQSLQQQQ-----RLS 314
                                                             ||:.||||     :|.
  Fly   896 QLIQQQLQQQAQAQVQAQVQAQAQQQQQQREQQQNIIQQIVVQQSGATSQQTSQQQQHHQSGQLQ 960

  Fly   315 PPSGP-SMATATTTSSLSSSSSASASASAS------------------ASAAT-----HMPLHNL 355
            ..|.| |::::||.:.:::||:..|:.|||                  :|..|     ..||...
  Fly   961 LSSVPFSVSSSTTPAGIATSSALQAALSASGAIFQTAKPGTCSSSSPTSSVVTITNQSSTPLVTS 1025

  Fly   356 STNLLNSIQQAAASQQQLRSSNSNSSSNISGSSNNTKSDGGAASNATDFSTRNYSDIMRCLAAKY 420
            ||  :.|||||.....|:.......|:.|:|.:.. :..|..:...|.......:.:|.......
  Fly  1026 ST--VASIQQAQTQSAQVHQHQQLISATIAGGTQQ-QPQGPPSLTPTTNPILAMTSMMNATVGHL 1087

  Fly   421 NNANPNDNNATRRNSYYDGSTSATTATG------GAGGGGGGAGGSNSAPSSALKTASS------ 473
            :.|.|...:.|        ||:.|::.|      .|..||||     |.|::..|...|
  Fly  1088 STAPPVTVSVT--------STAVTSSPGQLVLLSTASSGGGG-----SIPATPTKETPSKGPTAT 1139

  Fly   474 -----------STGSTTTTAKKLSPSAASAANSAAVSLSKESKVSAVGGAGVGGAVASSGGGGSS 527
                       |...|.||.|..:|:..||:..|:.|..:                |.|.|..|.
  Fly  1140 LVPIGSPKTPVSGKDTCTTPKSSTPATVSASVEASSSTGE----------------ALSNGDASD 1188

  Fly   528 MSQLAPPPTAPSPTEQAKSQMAAVVAAASVSPFMTNFLPFSSGIFPP-------LIDMSSTQALL 585
            .|. .|...|.:||  :|...|||...:|.:|...      ||...|       |...:||....
  Fly  1189 RSS-TPSKGATTPT--SKQSNAAVQPPSSTTPNSV------SGKEEPKLATCGSLTSATSTSTTT 1244

  Fly   586 TLARAVKDAEIQEILRSKQQRSGSNASSPSASAAGT-----PRSSSTLNAALHQAAQFVTPALI- 644
            |:...:      .:.|:....:.|.||:.:.| :||     ..:::|..:::...::.:..|:|
  Fly  1245 TITNGI------GVARTTASTAVSTASTTTTS-SGTFITSCTSTTTTTTSSISNGSKDLPKAMIK 1302

  Fly   645 --------------------------YS------------AQLQQQ-----------------QQ 654
                                      |:            |.:|:.                 :|
  Fly  1303 PNVLTHVIDGFIIQEANEPFPVTRQRYADKDVSDEPPKKKATMQEDIKLSGIASAPGSDMVACEQ 1367

  Fly   655 QQQQQHQ---RQQQQQSQHASRQSSPRSTNDSTTVAPIGDG-------GGGSSIASAAPLDLSSQ 709
            ..:.:|:   ::::..|...|||:       ...:..:|.|       ||...:.:.|.:|...:
  Fly  1368 CGKMEHKAKLKRKRYCSPGCSRQA-------KNGIGGVGSGETNGLGTGGIVGVDAMALVDRLDE 1425

  Fly   710 PPAAKRFKAERR----------ASSTATTATTATTGSSTSTPSP--PPLEQHDDINSGNANATLG 762
            ..|.::.:.|..          .:||.....:....::.|.|||  .||       ....:..|.
  Fly  1426 AMAEEKMQTEATPKLSESFPILGASTEVPPMSLPVQAAISAPSPLAMPL-------GSPLSVALP 1483

  Fly   763 TRSGTGTGESSAAGSGAGVAKARRRCQAQSEEVNSWSVDDVCGFVGGIDICAEYVQSFRDQSIDG 827
            |.:......|.||...:.|....|      ..::|||||||..|:..:..|.:||..|..|.|||
  Fly  1484 TLAPLSVVTSGAAPKSSEVNGTDR------PPISSWSVDDVSNFIRELPGCQDYVDDFIQQEIDG 1542

  Fly   828 TGLPLLTEDHLVNSLGMKLGPALKLRSILAKKLGGPCPCVACVAQAQQMLALQTGGAAAATGA 890
            ..|.||.|.||||::|||||||||:                 ||:.:.:..:...|.|...||
  Fly  1543 QALLLLKEKHLVNAMGMKLGPALKI-----------------VAKVESIKEVPPPGEAKDPGA 1588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Samuel	NP_001260372.1	SAM_Samd7,11	795..862	CDD:188978	33/66 (50%)
Samuel	NP_001260372.1	SAM	795..852	CDD:197735	32/56 (57%)
ph-p	NP_476871.2	SAM_Ph1,2,3	1508..1576	CDD:188976	35/84 (42%)
ph-p	NP_476871.2	SAM	1511..1576	CDD:197735	35/81 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12247
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100