DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Samuel and Phc3

DIOPT Version :9

Sequence 1:	NP_001260372.1	Gene:	Samuel / 34530	FlyBaseID:	FBgn0032330	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	XP_006232288.1	Gene:	Phc3 / 310258	RGDID:	1307998	Length:	1011	Species:	Rattus norvegicus

Alignment Length:	1044	Identity:	190/1044 - (18%)
Similarity:	319/1044 - (30%)	Gaps:	395/1044 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 SAPASSASSSSMSSSSAGSTCTTNANTASVAAAYAAFYLEKVKHEKMDNHKDAPMVTIHNNNNNN 215
            :|..|..||.:..|::|.||.||...|:|                   :....|.:::::.::.:
  Rat    11 TAMESEPSSGTSVSTTASSTTTTTITTSS-------------------SRMQQPQISVYSGSDRH 56

  Fly   216 TIN------NNNSSSSS-----------------SSSIINNHQSSQPSLGHSVKRERLSPGSNSS 257
            .:.      :...||::                 ::::...|.||......:..:..||.|..|:
  Rat    57 AVQVIQQALHRPPSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSSSQLQSLAAVQASLSSGRPST 121

  Fly   258 SHNGELT------VSSFARSRSATPSSSSYRG-AGGGAGGGV--------SPSHQQQQQQQQQSL 307
            |..|.:|      .:|...|.|.||:....|. |.....|.:        |.|......|.|..|
  Rat   122 SPTGSVTQQSSMSQTSINLSTSPTPAQLMSRSQASSSTSGSITQQTMLLGSTSPTLTASQAQMYL 186

  Fly   308 QQQQRLSPPSGPSMATATTTSSLSS-----SSSASASASASASAATHMPLHNLSTNLLNSIQ--- 364
            :.|..:..|       |||.:::.|     |||.|.|..::|:...::.|.:....:|:|.|
  Rat   187 RAQMLIFTP-------ATTVAAVQSDIPVVSSSPSPSCQSAAAQVQNLTLRSQKLGVLSSSQNGP 244

  Fly   365 -QAAASQQQL---RSSNSNSSSNIS--GSSNNTKSDGGAASNATDFSTRNYSDIMRCLA-AKYNN 422
             ::|...|.|   .:..:.:||.||  ..|..:|..|.....:...:....|.|.:.:| |.|:.
  Rat   245 PKSAGQTQSLTICHNKTTVTSSKISQRDPSPESKKGGSPGLESRSTAVTRTSSIHQLIAPASYSP 309

  Fly   423 ANPND------------------------------NNATRRNSYYDGSTSATTATGGAGGGGGGA 457
            ..|:.                              ...|.::...|...|....
  Rat   310 IQPHSLIKHQQIPLHSPPPKVSHHQLILQQQQQQIQPITLQSPSQDPPPSQHCI----------- 363

  Fly   458 GGSNSAPSSALKTASSSTGSTTTTAK--------KLSPSAASAANSAAV-------SLSKESKV- 506
                ..|:..|..|||:..|....:.        .:|||.|.:|..:.|       |.|:...:
  Rat   364 ----PLPNHGLSPASSNAQSQQHCSPIQSHPPPLTVSPSQAQSAQQSVVVSPPPAHSPSQSPTII 424

  Fly   507 --------------SAV-GGAGVGGAVASSGGGGSSMSQL-----APPPTAP----SPTEQAK-- 545
                          ||: .|..:..|.|..   ..|.:||     .|.|.:|    .|.:|:.
  Rat   425 IHPQALVQPHPLVSSALHTGPNLQQATADQ---VQSTAQLNLPSHLPLPASPVVHIGPVQQSALV 486

  Fly   546 ---SQMAAVVAAASVSPFMTNFLPFSSGIFPPLIDMSSTQALLTL-ARAVKDAEIQEILRSKQQR 606
               .|:.:..:....|...::.:|.::   ||.:..|....:..| .::::..::|..:.|:.|.
  Rat   487 SPGQQIVSPTSHQQYSTLQSSPIPIAT---PPQMSASPPAQIPPLPLQSMQSLQVQPEILSQGQV 548

  Fly   607 SGSNA-----SSPSASA-------AGTPRSSSTLNAALHQAAQFVTPA----------LIYSAQL 649
            ...||     ..|:|.|       ...|..:..:|..:...|....|.          .::|.::
  Rat   549 LVQNALVSEEELPAAEALVQLPFQTLPPPQTVAVNLQVQPPAPVDPPVGMHLNQCHLHKVFSLKV 613

  Fly   650 QQQQQQQQQQHQRQQQQQSQHASRQSSPRSTNDSTTVAPIGDGGGGSSIASAAPLDLSSQPPAAK 714
            .|.:...:::...:..:.::.......|..:..:.||      |.|..:.|..||....:.||..
  Rat   614 YQVEDVCEEERPEESDECARMDRTPPPPTLSPAAITV------GRGEDLTSEHPLLEQVELPAVA 672

  Fly   715 RFKAERRASSTATTATTA-----------TTGSST----STPS----PP---------------- 744
            ...|....|.:..|..:|           |..|||    ||||    ||
  Rat   673 SVSASVIKSPSDPTHVSAPAPPLLMPAASTRSSSTSLASSTPSLENKPPQAIVKPQILTHVIEGF 737

  Fly   745 -------------------------PLEQHDDINS--------------GNA------------- 757
                                     ||..:..:||              .|:
  Rat   738 VIQEGLEPFPVSRSSLLIEQPVKKRPLLDNQVVNSVCVQPELQNNTKHADNSSDTEMEDMIAEET 802

  Fly   758 --------------------------------------------------------NATLGTRSG 766
                                                                    |.:||.|..
  Rat   803 LEEMDSELLKCEFCGKMGYPNEFLRSKRFCTMSCAKRYNVSCSKKFALSRWNRKPDNQSLGHRGR 867

  Fly   767 TGTGESSAAGS-------------------------GAGVAKARRRCQAQSE------------- 793
            ..:|...||..                         .|...:.||:.:.:.|
  Rat   868 RPSGPEGAAREHILRQLPITYPSAEEDLASRDDPVPSAMTTRLRRQSERERERELRDVRIRKMPE 932

  Fly   794 ----------EVNSWSVDDVCGFVGGIDICAEYVQSFRDQSIDGTGLPLLTEDHLVNSLGMKLGP 848
                      |.:.|:||||..|:..:..|.:....||.|.|||..|.||.||||::::.|||||
  Rat   933 NSDLLPVAQTEPSIWTVDDVWAFIHSLPGCQDVADEFRAQEIDGQALLLLKEDHLMSTMNMKLGP 997

  Fly   849 ALKL 852
            |||:
  Rat   998 ALKI 1001

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Samuel	NP_001260372.1	SAM_Samd7,11	795..862	CDD:188978	28/58 (48%)
Samuel	NP_001260372.1	SAM	795..852	CDD:197735	27/56 (48%)
Phc3	XP_006232288.1	SAM_Ph1,2,3	942..1010	CDD:188976	29/60 (48%)
Phc3	XP_006232288.1	SAM	944..1011	CDD:197735	28/58 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12247
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100