DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Samuel and Phc3

DIOPT Version :9

Sequence 1:	NP_001260372.1	Gene:	Samuel / 34530	FlyBaseID:	FBgn0032330	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	XP_006535530.1	Gene:	Phc3 / 241915	MGIID:	2181434	Length:	1009	Species:	Mus musculus

Alignment Length:	1050	Identity:	191/1050 - (18%)
Similarity:	319/1050 - (30%)	Gaps:	390/1050 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 APTDILQQKPAKATTAIVGGRSAAQPATHDDQEAATTASTATKRKHLERLASDLRQLGKKGRRSR 85
            :||..:.|:.:.:.|:|:....|.....:..|.:::|:.:.|::..|         ||
Mouse   122 SPTGSVTQQSSMSQTSILSASPAPAQLMNRSQTSSSTSGSITQQTML---------LG------- 170

  Fly    86 SVSPCSRYPAVAETARMLSERSLLL-----------SGYGAIESSAKKLSEAAT----------- 128
            |.||    ...|..|:|.....:|:           |....:.||.....::|.
Mouse   171 STSP----TLTASQAQMYLRAQMLIFTPATTVAAVQSDIPVVSSSPSPSCQSAAAQVQNLTLRSQ 231

  Fly   129 -----GGAGGGGGGAAGQA---------ATPTTSQLS----APAS-SASSSSMSSSSAGSTCTTN 174
                 ..:..|...:|||.         .|.|:|::|    :|.| ...|..:.|.|...|.|::
Mouse   232 KLGVLSSSQNGSPKSAGQTQSLTICHNKTTVTSSKISQRDPSPESKKGGSPGLESRSTAVTRTSS 296

  Fly   175 ANTASVAAAYAAFYLEK-VKHEKMDNHKDAPMVTIHN---NNNNNTINNNNSSSSSSSSIINNHQ 235
            .:.....|:|:...... :||:::..|...|.|:.|.   ......|......|.|.....:.|.
Mouse   297 IHQLIAPASYSPIQPHSLIKHQQIPLHSPPPKVSHHQLLLQQQQQQIQPITLQSPSQDPPPSQHC 361

  Fly   236 SSQPSLGHSVKRERLSPGSNSS---------SHNGELTVSSFARSRSATPSSSSYRGAGGGAGGG 291
            ...|:.|       |||..:::         ||...||||. .:::||..|..
Mouse   362 IPLPNHG-------LSPAPSNAQPQHCSPVQSHPPPLTVSP-NQAQSAQQSVV------------ 406

  Fly   292 VSPSHQQQQQQQQQSLQQQQRLSPPSGPSMATATTTS-SLSSSSSASASASASASAATHMPLHNL 355
            |||.......|....:...|.|..|. |.:::|..|. :|..:::....::|..:..:|:||...
Mouse   407 VSPPPPHSPSQSPTIIIHPQALIQPH-PLVSSALQTGPNLQQAAADQVQSTAQLNLPSHLPLPAS 470

  Fly   356 STNLLNSIQQAA--ASQQQLRSSNSNSSSNISGSSNNTKSDGGAASNATDFSTRNYSDIMRCLAA 418
            ....:..:||:|  :..||:.|..|:                           :.||.:.
Mouse   471 PVVHIGPVQQSALVSPGQQMVSPTSH---------------------------QQYSALQ----- 503

  Fly   419 KYNNANPNDNNATRRNSYYDGSTSATTATGGAGGGGGGAGGSNSAPSSALKTASSSTGSTTTTAK 483
                                                          ||.:..|:....|.:..|
Mouse   504 ----------------------------------------------SSPIPIATPPQMSASPPA- 521

  Fly   484 KLSPSAASAANSAAVSLSKESKVSAVGGAGVGGAVASSG--GGGSSMSQLAPPPTAPSPTEQAKS 546
            :|.|....:..    ||..:.::.:.|...|..|:.|..  ....::.|| |..|.|.|
Mouse   522 QLPPLPLQSMQ----SLQVQPEILSQGQVLVQNALVSEEELPAAEALVQL-PFQTLPPP------ 575

  Fly   547 QMAAVVAAASVSPFMTNFLPFSSGIFPPLIDMSSTQALLTLARAVKDAEIQEILRSKQQRSGSNA 611
              ..|.....|.|        .:.:.|| :.|...|..|....::|..:::::...:........
Mouse   576 --QTVAVNLQVQP--------PAPVDPP-VGMHLNQCHLHKVFSLKVYQVEDVCEEEMPEESDEC 629

  Fly   612 S-----------SPSASAAGTPRSSSTLNAALHQ----AAQFVTPALIYSAQLQQQQQQQQQQHQ 661
            :           ||:|...|.....::.:..|.|    |...|:.::|.|
Mouse   630 ARMDRTPPPPTLSPAAVTVGRGEDLTSEHPLLEQVELPAVASVSASVIKS--------------- 679

  Fly   662 RQQQQQSQHASRQSSP-----RSTNDSTTVAPIGDGGGGSSIASAAPLDLSSQPPAA-------- 713
               .....|||..:.|     .||..|:|           |:||:.| .|.::||.|
Mouse   680 ---PSDPTHASAPAPPLLIPAASTRSSST-----------SLASSTP-SLENKPPQAIVKPQILT 729

  Fly   714 -----------------------------KRFKAERRASSTATTA-----TTATTGSSTSTP--- 741
                                         ||...:.:..::....     .|....:|:.|.
Mouse   730 HVIEGFVIQEGLEPFPVSRSSLLIEQPVKKRPLLDNQVVNSVCVQPELQNNTKHADNSSDTEIED 794

  Fly   742 --SPPPLEQHDD--------------------------------------------INSGNANAT 760
              :...||:.|.                                            .|....|.:
Mouse   795 MMAEETLEEMDSELLKCEFCGKMGYPNEFLRSKRFCTMSCAKRYNVSCSKKFALSRWNRKPDNQS 859

  Fly   761 LGTRSGTGTGESSAAGS-------------------------GAGVAKARRRCQAQSE------- 793
            ||.|....:|...||..                         .|...:.||:.:.:.|
Mouse   860 LGHRGRRPSGPEGAAREHILRQLPITYPSAEEDVASHEDPVPSAMTTRLRRQSERERERELRDVR 924

  Fly   794 ----------------EVNSWSVDDVCGFVGGIDICAEYVQSFRDQSIDGTGLPLLTEDHLVNSL 842
                            |.:.|:||||..|:..:..|.:....||.|.|||..|.||.||||::::
Mouse   925 IRKMPENSDLLPVAQTEPSIWTVDDVWAFIHSLPGCQDVADEFRAQEIDGQALLLLKEDHLMSAM 989

  Fly   843 GMKLGPALKL 852
            .||||||||:
Mouse   990 NMKLGPALKI 999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Samuel	NP_001260372.1	SAM_Samd7,11	795..862	CDD:188978	28/57 (49%)
Samuel	NP_001260372.1	SAM	795..852	CDD:197735	27/56 (48%)
Phc3	XP_006535530.1	Atrophin-1	224..>595	CDD:367360	89/492 (18%)
		PAT1	<352..>516	CDD:370676	43/262 (16%)
		SAM_Ph1,2,3	940..1008	CDD:188976	29/59 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12247
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100