Protein Alignment Samuel and PHC2

DIOPT Version :9

• Sequence 1: NP_001260372.1
• Gene: Samuel / 34530
• FlyBaseID: FBgn0032330
• Length: 968
• Species: Drosophila melanogaster
• Sequence 2: NP_001372041.1
• Gene: PHC2 / 1912
• HGNCID: 3183
• Length: 881
• Species: Homo sapiens
• Alignment Length: 951
• Identity: 192/951 - (20%)
• Similarity: 290/951 - (30%)
• Gaps: 375/951 - (39%)

  Fly   197 MDNHKDAPMVTIHNNNNNNTINNNNSSSSSSSSIINNHQSSQPSLGHSVKRERLSPGSNSSSHNG 261
            |:|....|      :.:::....:::|.:||||..||  ||....|...       |...|.::|
Human     1 MENELPVP------HTSSSACATSSTSGASSSSGCNN--SSSGGSGRPT-------GPQISVYSG 50

  Fly   262 ---ELTVSSFARSRSATPSSSSYRGAGGGAGGGVSPSHQQQQ---QQQQQSLQ----QQQRLSPP 316
               ..||....::....||:::              .:.||.   |||...||    |||.||..
Human    51 IPDRQTVQVIQQALHRQPSTAA--------------QYLQQMYAAQQQHLMLQTAALQQQHLSSA 101

  Fly   317 SGPSMATATTTSSLSSSSSASASASASASAATHMPLHNLSTNLLNSIQQAAASQ--QQLRSSNSN 379
            ...|:|.....|.:|:...:::.::.||.|    |..:.|.||..|   .||:|  .:.:|.||.
Human   102 QLQSLAAVQQASLVSNRQGSTSGSNVSAQA----PAQSSSINLAAS---PAAAQLLNRAQSVNSA 159

  Fly   380 SSSNISGSS---NNTKSDGGAASNATDF------STRNYSDIMRCLAAKYNNA-----NPNDNNA 430
            ::|.|:..:   .||.|....||.|..:      ...|...:.|.|......:     .|....|
Human   160 AASGIAQQAVLLGNTSSPALTASQAQMYLRAQMAQPGNLVQVARSLGGTVPLSPQLIFTPTATVA 224

  Fly   431 TRRNSYYDGS-------------TSATTATGGAGGGGGGAGGSNSAPSSALKTASSSTGSTTTTA 482
            |.:.....||             |..|..| .|....|........||.|||.....:....|.|
Human   225 TVQPELGTGSPARPPTPAQVQNLTLRTQQT-PAAAASGPTPTQPVLPSLALKPTPGGSQPLPTPA 288

  Fly   483 KKLSPSAASAANS---AAVSLSKESKVSAVGGAGVGGAVASSGGGGSSMSQLA------------ 532
            :..:.:.||.|.:   .|.|:.:..| ...|.:.|.|::....|...::..:|
Human   289 QSRNTAQASPAGAKPGIADSVMEPHK-KGDGNSSVPGSMEGRAGLSRTVPAVAAHPLIAPAYAQL 352

  Fly   533 ------------------------------PPPTAPSPTEQAK--SQMAAVVAAASVSPF----- 560
                                          |||....|..||:  .|:|:|..:.::.|.
Human   353 QPHQLLPQPSSKHLQPQFVIQQQPQPQQQQPPPQQSRPVLQAEPHPQLASVSPSVALQPSSEAHA 417

  Fly   561 -----MTNFLPF------------SSGIFPPLID-------------------MSSTQALLTLAR 589
                 :|..||.            |....||..|                   ..::..:|.|..
Human   418 MPLGPVTPALPLQCPTANLHKPGGSQQCHPPTPDTGPQNGHPEGVPHTPQRRFQHTSAVILQLQP 482

  Fly   590 A-------VKDAEIQEILRSK----QQRSGSNASSPSASAAGT--------PRSSSTLNAALHQA 635
            |       |.| :.:|:...:    :.|||   .||...|..|        |.|.:...:..|:.
Human   483 ASPVPQQCVPD-DWKEVAPGEKSVPETRSG---PSPHQQAIVTAMPGGLPVPTSPNIQPSPAHET 543

  Fly   636 AQFVTPALIYSAQLQQQQQQQQQQHQRQQQQQSQHASRQSSPRSTNDSTTVAPIGDGGGGSSIAS 700
            .|.:..||                            :..|||..|:        |:|...||||.
Human   544 GQGIVHAL----------------------------TDLSSPGMTS--------GNGNSASSIAG 572

  Fly   701 AAPLDLSSQPPA----------------------------------------------------- 712
            .||.:..::||.
Human   573 TAPQNGENKPPQAIVKPQILTHVIEGFVIQEGAEPFPVGRSSLLVGNLKKKYAQGFLPEKLPQQD 637

  Fly   713 ------------------------------------AKRFKAERRASSTATT------------- 728
                                                |.:||..:|..|.|..
Human   638 HTTTTDSEMEEPYLQESKEEGAPLKLKCELCGRVDFAYKFKRSKRFCSMACAKRYNVGCTKRVGL 702

  Fly   729 -----ATTATTGSST------STPSPPPLEQHDDINSGNANATLGTRSG---TGTGESSAAGS-- 777
                 :.....|::|      |..|.|||.: |..........|...:.   |.:.|.|:..|
Human   703 FHSDRSKLQKAGAATHNRRRASKASLPPLTK-DTKKQPTGTVPLSVTAALQLTHSQEDSSRCSDN 766

  Fly   778 ----------GAGVAKARRRCQAQSE---------------------EVNSWSVDDVCGFVGGID 811
                      .|..:.:||| |.|.:                     |...|:|:||..|:..:.
Human   767 SSYEEPLSPISASSSTSRRR-QGQRDLELPDMHMRDLVGMGHHFLPSEPTKWNVEDVYEFIRSLP 830

  Fly   812 ICAEYVQSFRDQSIDGTGLPLLTEDHLVNSLGMKLGPALKL 852
            .|.|..:.||.|.|||..|.||.||||::::.:|||||||:
Human   831 GCQEIAEEFRAQEIDGQALLLLKEDHLMSAMNIKLGPALKI 871

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Samuel	NP_001260372.1	SAM_Samd7,11	795..862	CDD:188978	27/58 (47%)
		SAM	795..852	CDD:197735	26/56 (46%)
PHC2	NP_001372041.1	PHA03247	<116..571	CDD:223021	98/503 (19%)
		PHC2_SAM_assoc	693..812	CDD:406912	19/120 (16%)
		SAM_Ph1,2,3	812..880	CDD:188976	28/60 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12247
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100