DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Samuel and PHC1

DIOPT Version :9

Sequence 1:	NP_001260372.1	Gene:	Samuel / 34530	FlyBaseID:	FBgn0032330	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	XP_011518905.1	Gene:	PHC1 / 1911	HGNCID:	3182	Length:	1021	Species:	Homo sapiens

Alignment Length:	1081	Identity:	205/1081 - (18%)
Similarity:	295/1081 - (27%)	Gaps:	503/1081 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 MVTIHNNNNNNTINNNNSSSSSSSSIINNHQSSQPSL-----GHSVKRERLSPGSNSSSH----- 259
            |.|....|:|:|   |.||||..||   ..|.:|.||     ..:::..:..|.:....|
Human     1 METESEQNSNST---NGSSSSGGSS---RPQIAQMSLYERQAVQALQALQRQPNAAQYFHQFMLQ 59

  Fly   260 ----NGEL-TVSSFARSRSATPSSSSYRGAGGGAGGGVSPSHQQQQQQQQQSLQQQQRLSPPSGP 319
                |.:| ::::..:.|...|:..  ||.|......::.|  :|......|..|||..:..:..
Human    60 QQLSNAQLHSLAAVQQVRGQQPAGP--RGRGQALQATIAAS--RQASSPNTSTTQQQTTTTQASI 120

  Fly   320 SMATATTTSSLSSSSSASASASASASAATH-MPLHNLSTNLLNSIQQAAASQQQLRSS------- 376
            ::||.:....:|.|.|.|   |.||:..|. :.|.|.::..||..|    :|..||..
Human   121 NLATTSAAQLISRSQSVS---SPSATTLTQSVLLGNTTSPPLNQSQ----AQMYLRPQLGNLLQV 178

  Fly   377 NSNSSSNISGSSNNTKSDGGAASNATDFSTRNYSDIMRCLAAKYNNANPNDNNATRRNSYYDGST 441
            |.....|:..:|.......||.:..........|..:...|.:..|....:..|:.:.....|||
Human   179 NRTLGRNVPLASQLILMPNGAVAAVQQEVPSAQSPGVHADADQVQNLAVRNQQASAQGPQMQGST 243

  Fly   442 SATTATGGAGGGGGGAGGSNSAPSSALKTASSSTGSTTTTAKKLSPSAASAANSAAVSLSKESKV 506
            ......|.:     .....:.|.|.||..|.:|:|:|..:. .||.:...:.||...|:......
Human   244 QKAIPPGAS-----PVSSLSQASSQALAVAQASSGATNQSL-NLSQAGGGSGNSIPGSMGPGGGG 302

  Fly   507 SAVGGAGVGGAVASSGGGGSSMSQ-----LAPPPTAPSPTEQAKSQMAAVVAAASVSPFMTNFLP 566
            .|.||.   |.:.|||.||.|..:     :.|.|.|.:.|....||..|..|||
Human   303 QAHGGL---GQLPSSGMGGGSCPRKGTGVVQPLPAAQTVTVSQGSQTEAESAAA----------- 353

  Fly   567 FSSGIFPPLIDMSSTQALLTLARAVKDAEIQEILRSKQQRSGSNASSPSASAAGTPRSSSTL--- 628
                                     |.||..   .|.||..|.|     .:...||..|.||
Human   354 -------------------------KKAEAD---GSGQQNVGMN-----LTRTATPAPSQTLISS 385

  Fly   629 -----------------------------NAALHQAAQFV--TPALIYSA---QLQQQQQQQQQQ 659
                                         ..|:|...||.  ...|:::|   ||.|||||||||
Human   386 ATYTQIQPHSLIQQQQQIHLQQKQVVIQQQIAIHHQQQFQHRQSQLLHTATHLQLAQQQQQQQQQ 450

  Fly   660 HQRQQQ----------------------QQSQHASR--------QSSPRS------------TND 682
            .|:|||                      .|||..::        ||||.|            ...
Human   451 QQQQQQPQATTLTAPQPPQVPPTQQVPPSQSQQQAQTLVVQPMLQSSPLSLPPDAAPKPPIPIQS 515

  Fly   683 STTVAPI----------------------------------GDGGGGSSIASAAPLD-------- 705
            ...||||                                  ....|.:.:|:|.|..
Human   516 KPPVAPIKPPQLGAAKMSAAQQPPPHIPVQVVGTRQPGTAQAQALGLAQLAAAVPTSRGMPGTVQ 580

  Fly   706 -----LSSQPPAAKRFKAERRASSTAT----------TATTATTGSSTSTP-------------- 741
                 |:|.||:::...|.:....|..          ||.....|::||:|
Human   581 SGQAHLASSPPSSQAPGALQECPPTLAPGMTLAPVQGTAHVVKGGATTSSPVVAQVPAAFYMQSV 645

  Fly   742 ----SPPPL---------EQHDDINS--------------------------------GNANAT- 760
                .|..|         |:.||:::                                .|.||.
Human   646 HLPGKPQTLAVKRKADSEEERDDVSTLGSMLPAKASPVAESPKVMDEKSSLGEKAESVANVNANT 710

  Fly   761 ----------------------------------------------------------------- 760

Human   711 PSSELVALTPAPSVPPPTLAMVSRQMGDSKPPQAIVKPQILTHIIEGFVIQEGAEPFPVGCSQLL 775

  Fly   761 ------LGTRSGTGTGESSAAG------------------------------------------- 776
                  |.|...||..|:.:.|
Human   776 KESEKPLQTGLPTGLTENQSGGPLGVDSPSAELDKKANLLKCEYCGKYAPAEQFRGSKRFCSMTC 840

  Fly   777 ----------------------SGAGVAKARRR-----------------CQAQSEE-------- 794
                                  ..|..|:.|||                 |....|:
Human   841 AKRYNVSCSHQFRLKRKKMKEFQEANYARVRRRGPRRSSSDIARAKIQGKCHRGQEDSSRGSDNS 905

  Fly   795 ---------------------------------------VN---------SWSVDDVCGFVGGID 811
                                                   :|         .|||::|..|:..:.
Human   906 SYDEALSPTSPGPLSVRAGHGERDLGNPNTAPPTPELHGINPVFLSSNPSRWSVEEVYEFIASLQ 970

  Fly   812 ICAEYVQSFRDQSIDGTGLPLLTEDHLVNSLGMKLGPALKL 852
            .|.|..:.||.|.|||..|.||.|:||::::.:|||||||:
Human   971 GCQEIAEEFRSQEIDGQALLLLKEEHLMSAMNIKLGPALKI 1011

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Samuel	NP_001260372.1	SAM_Samd7,11	795..862	CDD:188978	27/67 (40%)
Samuel	NP_001260372.1	SAM	795..852	CDD:197735	26/65 (40%)
PHC1	XP_011518905.1	zf-FCS	809..844	CDD:283998	0/34 (0%)
		PHC2_SAM_assoc	845..951	CDD:293222	8/105 (8%)
		SAM_Ph1,2,3	952..1020	CDD:188976	26/60 (43%)
		SAM	954..1021	CDD:197735	26/58 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12247
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.100