DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Samuel and SAMD11

DIOPT Version :9

Sequence 1:	NP_001260372.1	Gene:	Samuel / 34530	FlyBaseID:	FBgn0032330	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	NP_001372569.1	Gene:	SAMD11 / 148398	HGNCID:	28706	Length:	845	Species:	Homo sapiens

Alignment Length:	830	Identity:	193/830 - (23%)
Similarity:	269/830 - (32%)	Gaps:	273/830 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 GQAATPTTSQLSAPAS-------SASSSSMSSSSAGSTCTTNANTASVAAAYAAFYLEKVKHEKM 197
            |:.|...|..|.|..:       |.|:|...|..:|.||.....               :|.|
Human   206 GRLADKRTVALPAARNLKKERTPSFSASDGDSDGSGPTCGRRPG---------------LKQE-- 253

  Fly   198 DNHKDAPMVTIHNNNNNNTINNNNSSSSSSSSIINNHQSSQPSLGHSVKRER--LSP--GSNSSS 258
                |.|.:.|.....:...:.|.|...:|.|    ...:.|:|..||.|.|  :.|  .|....
Human   254 ----DGPHIRIMKRRVHTHWDVNISFREASCS----QDGNLPTLISSVHRSRHLVMPEHQSRCEF 310

  Fly   259 HNGELTVSSFARSRSATPSSSSYRGAGG------GAGGGVSPSHQQQQQQQQQSLQQQQRLSPPS 317
            ..|.|.:              ..|.||.      |....:|.....:::.:.:|.|.:..|.|..
Human   311 QRGSLEI--------------GLRPAGDLLGKRLGRSPRISSDCFSEKRARSESPQAEALLLPRE 361

  Fly   318 -GPSMATATTTSSLSSSSSASASASASASAATHMPLHNLSTNLLNSIQQAAASQQQLRSSNSNSS 381
             |||||.......|.|:.| .||.........|:.|.  |.:||...|:.||:  .||..:...:
Human   362 LGPSMAPEDHYRRLVSALS-EASTFEDPQRLYHLGLP--SHDLLRVRQEVAAA--ALRGPSGLEA 421

  Fly   382 SNISGSSNNTKSDGGAASNATDFSTRNYSDIMRCLAAKYNNANPNDNNATRRNSYYDGSTSATTA 446
            ...|.::...:..|.|                                     .:.:|:..|
Human   422 HLPSSTAGQRRKQGLA-------------------------------------QHREGAAPA--- 446

  Fly   447 TGGAGGGGGGAGGSNSAPSSALKTASSSTGSTTTTAKKLSPSAASAANSAAVSLSKESKVSAVGG 511
                           :|||.:.:....            .|...|..|:..|:|....:...:
Human   447 ---------------AAPSFSERELPQ------------PPPLLSPQNAPHVALGPHLRPPFL-- 482

  Fly   512 AGVGGAVASSGGGGSSMSQLAPPPTAPSPTEQAKSQMAAVVAAASVSPFMTNFLPFSSGIFPPLI 576
             ||..|:..:.|.|                                      |||      |...
Human   483 -GVPSALCQTPGYG--------------------------------------FLP------PAQA 502

  Fly   577 DMSSTQALL----TLARAVKDAEIQEILRSKQQRSG-------SNASSPSASAAGTPRSSSTLNA 630
            :|.:.|..|    .|||....|   ::||.|:..|.       ..|..|:..|....|..:.| .
Human   503 EMFAWQQELLRKQNLARLELPA---DLLRQKELESARPQLLAPETALRPNDGAEELQRRGALL-V 563

  Fly   631 ALHQAAQFVTPALIYSAQLQQQQQQQQQQHQRQQQQQSQHASRQSSPRSTNDSTTVAPIGDGGGG 695
            ..|.||    |.|..                     ..|.......|..:.||...||   ..||
Human   564 LNHGAA----PLLAL---------------------PPQGPPGSGPPTPSRDSARRAP---RKGG 600

  Fly   696 SSIASAAPLDLSSQPPAAKRF-----KAERRASSTATTATTATTGSSTSTPSPPPLEQHDDINSG 755
            ...|||.|.: |.:...|:.:     :.|....|......||..|....||...|        :|
Human   601 PGPASARPSE-SKEMTGARLWAQDGSEDEPPKDSDGEDPETAAVGCRGPTPGQAP--------AG 656

  Fly   756 NANATLGTRSGTGTGESSA--------------AGSGAGVAKARRRCQAQSEEVNSWSVDDVCGF 806
            .|.|     .|.|....|.              .|:..|::.......| .|:|..|:|||||.|
Human   657 GAGA-----EGKGLFPGSTLPLGFPYAVSPYFHTGAVGGLSMDGEEAPA-PEDVTKWTVDDVCSF 715

  Fly   807 VGGIDICAEYVQSFRDQSIDGTGLPLLTEDHLVNSLGMKLGPALKLRSILAKKLGGPCPCVACVA 871
            |||:..|.||.:.||:|.|||..||||||:||:.::|:|||||||:|:.:|::||.    |..||
Human   716 VGGLSGCGEYTRVFREQGIDGETLPLLTEEHLLTNMGLKLGPALKIRAQVARRLGR----VFYVA 776

  Fly   872 QAQQMLALQ------------TG-GAAAATGATAGAGTVTGAVAGAGATS 908
            .....|.||            || ...:.|.||:..|   |..|.||.||
Human   777 SFPVALPLQPPTLRAPERELGTGEQPLSPTTATSPYG---GGHALAGQTS 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Samuel	NP_001260372.1	SAM_Samd7,11	795..862	CDD:188978	39/66 (59%)
Samuel	NP_001260372.1	SAM	795..852	CDD:197735	35/56 (63%)
SAMD11	NP_001372569.1	SAND	113..185	CDD:396076
SAMD11	NP_001372569.1	SAM_Samd7,11	704..771	CDD:188978	39/66 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	83	1.000	Domainoid score	I8358
eggNOG	1	0.900	-	-		E1_KOG4333
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006289
OrthoInspector	1	1.000	-	-		otm41156
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12247
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5499
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	6.030